GENE：LAMB3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LAMB3 |
| FullNmae | laminin subunit beta 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6490 |
| EnsembleID | ENSG00000196878 |
| Uniprot | Q13751 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LAMB3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LAMB3 | GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005610,GO:0007155,GO:0008544,GO:0035987,GO:0044877,GO:0050873,GO:0062023 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LAMB3 | hsa:3914 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| LAMB3 | hsa:3914 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LAMB3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | LAMB3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | LAMB3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | LAMB3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| U2AF2 | LAMB3 | 25348397 | N/A | physical interaction | ComPPI |
| PDIA3 | LAMB3 | 17170699 24234451 25348397 | disulfide bond | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| THBS1 | LAMB3 | 14525934 25348397 9840442 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| LAMA3 | LAMB3 | 25348397 | N/A | in vitro | ComPPI |
| CFTR | LAMB3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMA1 | LAMB3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MED14 | LAMB3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BMP1 | LAMB3 | 10806203 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| COL7A1 | LAMB3 | 14525934 25348397 9989793 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| LAMC2 | LAMB3 | 10964684 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| LAMB3 | ECM1 | 25348397 | N/A | two hybrid | ComPPI |
| LAMB3 | HSPD1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMB3 | MYEF2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMB3 | LGALS3BP | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMB3 | TOP1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMB3 | BAG2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMB3 | ATXN10 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SNRNP27 | LAMB3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MKI67 | LAMB3 | 24234451 26949251 | association | anti tag coimmunoprecipitation | IntAct |