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GENE：LIG4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LIG4
FullNmae DNA ligase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6601
EnsembleID ENSG00000174405
Uniprot P49917

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LIG4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LIG4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LIG4 GO:0000012,GO:0000781,GO:0000793,GO:0001701,GO:0002328,GO:0003677,GO:0003677,GO:0003909,GO:0003909,GO:0003910,GO:0003910,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005958,GO:0005958,GO:0005958,GO:0006260,GO:0006266,GO:0006297,GO:0006297,GO:0006302,GO:0006302,GO:0006303,GO:0006303,GO:0006303,GO:0006303,GO:0006303,GO:0007049,GO:0007417,GO:0008283,GO:0010165,GO:0010332,GO:0016874,GO:0022008,GO:0032807,GO:0032807,GO:0033077,GO:0033151,GO:0033152,GO:0033153,GO:0035019,GO:0043231,GO:0043524,GO:0045190,GO:0046872,GO:0048144,GO:0048146,GO:0050769,GO:0051102,GO:0051103,GO:0051103,GO:0051276,GO:0051301,GO:0051402,GO:0070419,GO:0071285,GO:0071479,GO:0071897,GO:0072089,GO:0075713,GO:0097680,GO:1904155,GO:2001252

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LIG4 hsa:3981 path:hsa03450 Non-homologous end-joining - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 LIG4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 LIG4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA LIG4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LIG4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LIG4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LIG4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LIG4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LIG4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 LIG4 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 LIG4 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKDC LIG4 22135298 phosphorylation N/A PhosphoSite
ATM LIG4 25361965 interaction type N/A PTMCode2
LIG4 ATM 25361965 interaction type N/A PTMCode2
XRCC4 LIG4 25361965 interaction type N/A PTMCode2
LIG4 XRCC4 25361965 interaction type N/A PTMCode2
NHEJ1 LIG4 25361965 interaction type N/A PTMCode2
LIG4 NHEJ1 25361965 interaction type N/A PTMCode2
APLF LIG4 25361965 interaction type N/A PTMCode2
LIG4 APLF 25361965 interaction type N/A PTMCode2
LIG4 RAD52 25361965 interaction type N/A PTMCode2
RAD52 LIG4 25361965 interaction type N/A PTMCode2
LIG4 PCNA 25361965 interaction type N/A PTMCode2
PCNA LIG4 25361965 interaction type N/A PTMCode2
ATR LIG4 25361965 interaction type N/A PTMCode2
LIG4 ATR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPANK1 LIG4 25348397 N/A physical interaction ComPPI
COL1A2 LIG4 25348397 N/A physical interaction ComPPI
LDHB LIG4 25348397 N/A physical interaction ComPPI
LDHA LIG4 25348397 N/A physical interaction ComPPI
ACTG1 LIG4 25348397 N/A physical interaction ComPPI
TP53BP1 LIG4 25348397 N/A physical interaction ComPPI
GSTP1 LIG4 25348397 N/A physical interaction ComPPI
RPL11 LIG4 25348397 N/A physical interaction ComPPI
FOXB1 LIG4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIG4 NHEJ1 14525934 16439205 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LIG4 PRKDC 14525934 15194694 22529269 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
LIG4 APLF 14525934 17396150 23178593 24234451 25348397 physical association experimental interaction detection,filter binding,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
LIG4 XRCC4 10854421 11702069 14525934 22529269 23219551 24234451 25348397 25416956 25910212 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
LIG4 PNKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG4 ATR 25348397 N/A physical interaction ComPPI
LIG4 ATM 25348397 N/A physical interaction ComPPI
LIG4 XRCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG4 XRCC5 25348397 N/A physical interaction ComPPI
LIG4 SMC2 12589063 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
LIG4 TOP1 25348397 N/A physical interaction ComPPI
LIG4 BTG1 25348397 N/A physical interaction ComPPI
LIG4 CLU 25348397 N/A physical interaction ComPPI
LIG4 CREBBP 25348397 N/A physical interaction ComPPI
LIG4 CTSK 25348397 N/A physical interaction ComPPI
LIG4 DGUOK 25348397 N/A physical interaction ComPPI
LIG4 EEF1A1 25348397 N/A physical interaction ComPPI
LIG4 EEF1A1P5 25348397 N/A physical interaction ComPPI
LIG4 EIF4A1 25348397 N/A physical interaction ComPPI
LIG4 ETF1 25348397 N/A physical interaction ComPPI
LIG4 GAPDH 25348397 N/A physical interaction ComPPI
LIG4 HK1 25348397 N/A physical interaction ComPPI
LIG4 HMGN1 25348397 N/A physical interaction ComPPI
LIG4 HNRNPA1 25348397 N/A physical interaction ComPPI
LIG4 HNRNPA2B1 25348397 N/A physical interaction ComPPI
LIG4 IPP 25348397 N/A physical interaction ComPPI
LIG4 LDHC 25348397 N/A physical interaction ComPPI
LIG4 MCM4 25348397 N/A physical interaction ComPPI
LIG4 MT-CO1 25348397 N/A physical interaction ComPPI
LIG4 MT-CO2 25348397 N/A physical interaction ComPPI
LIG4 MT-CO3 25348397 N/A physical interaction ComPPI
LIG4 MT-ND1 25348397 N/A physical interaction ComPPI
LIG4 MT-ND4 25348397 N/A physical interaction ComPPI
LIG4 MT-ND5 25348397 N/A physical interaction ComPPI
LIG4 NDUFB10 25348397 N/A physical interaction ComPPI
LIG4 NEU1 25348397 N/A physical interaction ComPPI
LIG4 PA2G4 25348397 N/A physical interaction ComPPI
LIG4 PEX10 25348397 N/A physical interaction ComPPI
LIG4 PSMA6 25348397 N/A physical interaction ComPPI
LIG4 SRSF2 25348397 N/A physical interaction ComPPI
LIG4 TLE4 25348397 N/A physical interaction ComPPI
LIG4 TPT1 25348397 N/A physical interaction ComPPI
LIG4 UBE2L3 25348397 N/A physical interaction ComPPI
LIG4 WARS1 25348397 N/A physical interaction ComPPI
LIG4 ALMS1 25348397 N/A physical interaction ComPPI
LIG4 THOC5 25348397 N/A physical interaction ComPPI
LIG4 EIF3I 25348397 N/A physical interaction ComPPI
LIG4 EIF4G3 25348397 N/A physical interaction ComPPI
LIG4 SNX3 25348397 N/A physical interaction ComPPI
LIG4 GGH 25348397 N/A physical interaction ComPPI
LIG4 CPNE1 25348397 N/A physical interaction ComPPI
LIG4 UNC119 25348397 N/A physical interaction ComPPI
LIG4 ATP6V0D1 25348397 N/A physical interaction ComPPI
LIG4 GRHPR 25348397 N/A physical interaction ComPPI
LIG4 DPP3 25348397 N/A physical interaction ComPPI
LIG4 RBM5 25348397 N/A physical interaction ComPPI
LIG4 ANAPC10 25348397 N/A physical interaction ComPPI
LIG4 MCRS1 25348397 N/A physical interaction ComPPI
LIG4 CAP1 25348397 N/A physical interaction ComPPI
LIG4 NPC2 25348397 N/A physical interaction ComPPI
LIG4 RUVBL2 25348397 N/A physical interaction ComPPI
LIG4 KDELR1 25348397 N/A physical interaction ComPPI
LIG4 KIF3A 25348397 N/A physical interaction ComPPI
LIG4 ZWINT 25348397 N/A physical interaction ComPPI
LIG4 PALLD 25348397 N/A physical interaction ComPPI
LIG4 B9D1 25348397 N/A physical interaction ComPPI
LIG4 TRAPPC3 25348397 N/A physical interaction ComPPI
LIG4 EIF2AK1 25348397 N/A physical interaction ComPPI
LIG4 OSTM1 25348397 N/A physical interaction ComPPI
LIG4 SYCP3 25348397 N/A physical interaction ComPPI
LIG4 MRPS18C 25348397 N/A physical interaction ComPPI
LIG4 LAP3 25348397 N/A physical interaction ComPPI
LIG4 NDUFA13 25348397 N/A physical interaction ComPPI
LIG4 AFTPH 25348397 N/A physical interaction ComPPI
LIG4 WBP1L 25348397 N/A physical interaction ComPPI
LIG4 OXR1 25348397 N/A physical interaction ComPPI
LIG4 OGFOD1 25348397 N/A physical interaction ComPPI
LIG4 DDX19A 25348397 N/A physical interaction ComPPI
LIG4 UFSP2 25348397 N/A physical interaction ComPPI
LIG4 FAM214A 25348397 N/A physical interaction ComPPI
LIG4 RHBDD2 25348397 N/A physical interaction ComPPI
LIG4 SEMA4G 25348397 N/A physical interaction ComPPI
LIG4 SOWAHC 25348397 N/A physical interaction ComPPI
LIG4 VKORC1 25348397 N/A physical interaction ComPPI
LIG4 BBOF1 25348397 N/A physical interaction ComPPI
LIG4 FIP1L1 25348397 N/A physical interaction ComPPI
LIG4 ZFAND2A 25348397 N/A physical interaction ComPPI
LIG4 RPS19BP1 25348397 N/A physical interaction ComPPI
LIG4 WDR20 25348397 N/A physical interaction ComPPI
LIG4 AGAP4 25348397 N/A physical interaction ComPPI
LIG4 ZNF428 25348397 N/A physical interaction ComPPI
LIG4 COMMD1 25348397 N/A physical interaction ComPPI
LIG4 ASPM 25348397 N/A physical interaction ComPPI
LIG4 PGP 25348397 N/A physical interaction ComPPI
LIG4 NOMO3 25348397 N/A physical interaction ComPPI
LIG4 ALDOA 25348397 N/A physical interaction ComPPI
LIG4 CTSD 25348397 N/A physical interaction ComPPI
LIG4 FLNA 25348397 N/A physical interaction ComPPI
LIG4 PFN1 25348397 N/A physical interaction ComPPI
LIG4 TGM3 25348397 N/A physical interaction ComPPI
LIG4 TPI1 25348397 N/A physical interaction ComPPI
LIG4 TAGLN2 25348397 N/A physical interaction ComPPI
LIG4 MYL12B 25348397 N/A physical interaction ComPPI
LIG4 MYL12A 25348397 N/A physical interaction ComPPI
LIG4 HIC2 25348397 N/A physical interaction ComPPI
LIG4 STRN3 25348397 N/A physical interaction ComPPI
LIG4 MICAL3 25348397 N/A physical interaction ComPPI
LIG4 COA7 25348397 N/A physical interaction ComPPI
LIG4 PPP1R18 25348397 N/A physical interaction ComPPI
LIG4 ENO1 25348397 N/A physical interaction ComPPI
LIG4 PPIA 25348397 N/A physical interaction ComPPI
LIG4 PHF10 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LIG4 GZMK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LIG4 TSFM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LIG4 ZSCAN18 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LIG4 AGO2 25348397 N/A physical interaction ComPPI
LIG4 CRBN 25348397 N/A physical interaction ComPPI
LIG4 DCLRE1C 22529269 23219551 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,isothermal titration calorimetry,pull down,x-ray crystallography ComPPI,IntAct
UBB LIG4 25348397 N/A physical interaction ComPPI
MAP2K2 LIG4 25348397 N/A physical interaction ComPPI
DDX19B LIG4 25348397 N/A physical interaction ComPPI
ATM LIG4 10608806 27898060 N/A N/A OmniPath
PRKDC LIG4 10608806 15194694 27898060 inhibition N/A OmniPath

Visualization










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