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GENE：SDC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SDC4
FullNmae syndecan 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10661
EnsembleID ENSG00000124145
Uniprot P31431

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SDC4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SDC4 GO:0001657,GO:0001843,GO:0001968,GO:0005080,GO:0005515,GO:0005796,GO:0005886,GO:0005886,GO:0005925,GO:0009986,GO:0010762,GO:0016477,GO:0042060,GO:0042130,GO:0042802,GO:0043034,GO:0043202,GO:0051496,GO:0051894,GO:0060122,GO:0070053,GO:0070062,GO:1903543,GO:1903553

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SDC4 hsa:6385 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
SDC4 hsa:6385 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
SDC4 hsa:6385 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
SDC4 hsa:6385 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SDC4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 SDC4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SDC4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SDC4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SDC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 SDC4 19212692 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 SDC4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A SDC4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E SDC4 25089138 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000001EB3 SDC4 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 SDC4 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D50C SDC4 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015188E SDC4 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 SDC4 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 SDC4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 SDC4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001067D1 SDC4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000CC005 SDC4 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC SDC4 22135298 phosphorylation N/A PhosphoSite
FGF2 SDC4 25361965 interaction type N/A PTMCode2
SDC4 FGF2 25361965 interaction type N/A PTMCode2
SDC2 SDC4 25361965 interaction type N/A PTMCode2
SDC4 SDC2 25361965 interaction type N/A PTMCode2
GIPC1 SDC4 25361965 interaction type N/A PTMCode2
SDC4 GIPC1 25361965 interaction type N/A PTMCode2
PRKCD SDC4 25361965 interaction type N/A PTMCode2
SDC4 PRKCD 25361965 interaction type N/A PTMCode2
CCL5 SDC4 25361965 interaction type N/A PTMCode2
SDC4 CCL5 25361965 interaction type N/A PTMCode2
SDCBP SDC4 25361965 interaction type N/A PTMCode2
SDC4 SDCBP 25361965 interaction type N/A PTMCode2
SDC4 CASK 25361965 interaction type N/A PTMCode2
CASK SDC4 25361965 interaction type N/A PTMCode2
SDC4 CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 SDC4 25361965 interaction type N/A PTMCode2
PRKCA SDC4 25361965 interaction type N/A PTMCode2
SDC4 PRKCA 25361965 interaction type N/A PTMCode2
MDK SDC4 25361965 interaction type N/A PTMCode2
SDC4 MDK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTA SDC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SGTB SDC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PMP22 SDC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PECAM1 SDC4 24234451 24497640 25348397 physical association proximity ligation assay ComPPI,IntAct
TIAM1 SDC4 23395182 24234451 25348397 N/A classical fluorescence spectroscopy,physical interaction ComPPI,IntAct
PRKCA SDC4 11916978 12571249 14525934 14670076 24234451 25348397 9556568 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
PRKCD SDC4 11916978 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SDC2 SDC4 18093920 24234451 25348397 N/A physical interaction,comigration in gel electrophoresis ComPPI,IntAct
UBC SDC4 25348397 N/A physical interaction ComPPI
CCL5 SDC4 14525934 14637022 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PXN SDC4 25348397 N/A in vitro ComPPI
SDC4 CASK 14525934 25348397 9660868 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SDC4 SDCBP 12241528 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SDC4 TGFB1I1 11805099 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SDC4 GIPC1 10911369 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SDC4 CXCR4 14525934 15819887 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
SDC4 MDK 14525934 25348397 27898060 8621465 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SDC4 FGF2 25348397 N/A physical interaction,enzyme linked immunosorbent assay ComPPI
SDC4 LTBP2 25348397 N/A enzyme linked immunosorbent assay ComPPI
SDC4 DVL1 25348397 N/A physical interaction ComPPI
SDC4 DVL1P1 25348397 N/A physical interaction ComPPI
SDC4 ELAVL1 25348397 N/A physical interaction ComPPI
SDC4 TGFB3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SDC4 TANK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SDC4 FGF1 25348397 N/A physical interaction ComPPI
SDC4 PTEN 25348397 N/A physical interaction ComPPI
SDC4 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SDC4 PLAAT4 25348397 N/A physical interaction ComPPI
SDC4 CYLD 25348397 N/A physical interaction ComPPI
SDC4 GPR183 25348397 N/A physical interaction ComPPI
SDC4 SDC3 18093920 24234451 25348397 N/A physical interaction,comigration in gel electrophoresis ComPPI,IntAct
SDC4 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SDC4 MAL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SDC4 IL7R 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SDC4 FAM20B 24234451 25331875 25348397 phosphorylation reaction phosphotransferase assay ComPPI,IntAct
SDC4 SDC4 11456484 14525934 18093920 24234451 9582338 N/A experimental interaction detection,tox-r dimerization assay,comigration in gel electrophoresis HPRD,IntAct
NCBP3 SDC4 24234451 26382858 association pull down IntAct
TGM2 SDC4 23499501 27898060 N/A N/A OmniPath
PRKCD SDC4 11916978 27898060 9556568 inhibition,stimulant N/A OmniPath
SDC4 DVL3 23151663 27898060 stimulant N/A OmniPath
SDC4 DVL1 23151663 27898060 stimulant N/A OmniPath
FGF2 SDC4 20382221 27898060 9012653 9556568 stimulant N/A OmniPath
CXCL10 SDC4 20484822 27898060 N/A N/A OmniPath
SDC4 DVL2 23151663 27898060 stimulant N/A OmniPath
CASK SDC4 27898060 9660868 N/A N/A OmniPath
ITK SDC4 12377772 27898060 N/A N/A OmniPath
RSPO3 SDC4 21397842 27898060 stimulant N/A OmniPath
RSPO2 SDC4 21397842 27898060 stimulant N/A OmniPath
ADAM12 SDC4 12509413 27898060 stimulant N/A OmniPath

Visualization










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