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GENE：SHC3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SHC3
FullNmae SHC adaptor protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18181
EnsembleID ENSG00000148082
Uniprot Q92529

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SHC3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SHC3 GO:0001784,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007417,GO:0030971,GO:0035556

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SHC3 hsa:53358 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
SHC3 hsa:53358 path:hsa01522 Endocrine resistance - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04510 Focal adhesion - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
SHC3 hsa:53358 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05034 Alcoholism - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05214 Glioma - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05224 Breast cancer - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
SHC3 hsa:53358 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGFR SHC3 23331499 8760305 9507002 stimulation N/A SignaLink
NTRK2 SHC3 23331499 9507002 stimulation N/A SignaLink
ALK SHC3 12185581 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SHC3 ERBB2 20005715 interaction type N/A PSP,SignaLink
SHC3 NTRK1 20005715 interaction type N/A PSP
SHC3 RET 20005715 interaction type N/A PSP
SHC3 AXL 20005715 interaction type N/A PSP
SHC3 FLT4 20005715 interaction type N/A PSP
SHC3 NTRK2 20005715 interaction type N/A PSP
SHC3 ALK 20005715 interaction type N/A PSP
SHC3 ALK 12185581 12185581 18988627 20005715 20005715 21071413 N/A N/A SignaLink
SHC3 AXL 20005715 20005715 N/A N/A SignaLink
SHC3 FLT4 20005715 20005715 N/A N/A SignaLink
SHC3 NTRK1 18988627 20005715 20005715 9507002 N/A N/A SignaLink
SHC3 NTRK2 12074588 18988627 20005715 20005715 21071413 9507002 N/A N/A SignaLink
SHC3 RET 12242309 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SHC3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SHC3 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 SHC3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SHC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SHC3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003804D8 SHC3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C SHC3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B SHC3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 SHC3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 SHC3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 SHC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 SHC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 SHC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 SHC3 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SHC3 ALK 25361965 interaction type N/A PTMCode2
ALK SHC3 25361965 interaction type N/A PTMCode2
NTRK2 SHC3 25361965 interaction type N/A PTMCode2
SHC3 NTRK2 25361965 interaction type N/A PTMCode2
EGFR SHC3 25361965 interaction type N/A PTMCode2
SHC3 EGFR 25361965 interaction type N/A PTMCode2
GRB2 SHC3 25361965 interaction type N/A PTMCode2
SHC3 GRB2 25361965 interaction type N/A PTMCode2
FLT4 SHC3 25361965 interaction type N/A PTMCode2
SHC3 FLT4 25361965 interaction type N/A PTMCode2
ERBB2 SHC3 25361965 interaction type N/A PTMCode2
SHC3 ERBB2 25361965 interaction type N/A PTMCode2
RET SHC3 25361965 interaction type N/A PTMCode2
SHC3 RET 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 SHC3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX11 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT86 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT33B SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT31 SHC3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 SHC3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PNMA1 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERBB2 SHC3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
KIT SHC3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GRB2 SHC3 12242309 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
AR SHC3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 SHC3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
NTRK1 SHC3 14525934 25348397 9507002 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NTRK2 SHC3 14525934 25348397 9507002 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKAR1B SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMD8 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF1 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF2 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MET SHC3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
RET SHC3 12242309 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
AXL SHC3 14525934 25348397 8610109 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGFR SHC3 14525934 16273093 24234451 25348397 9507002 N/A experimental interaction detection,protein array,physical interaction,in vivo ComPPI,HPRD,IntAct
FLT4 SHC3 14525934 25348397 9345034 N/A experimental interaction detection,in vitro ComPPI,HPRD
COPS6 SHC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 ALK 12185581 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SHC3 ARHGAP32 12446789 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SHC3 SH3GL3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SHC3 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
SHC3 SHC4 25348397 N/A physical interaction ComPPI
SHC3 APP 11877420 14525934 24234451 25348397 physical association experimental interaction detection,pull down ComPPI,HPRD,IntAct
SHC3 CDCA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 USHBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 GUSBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 CCNC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 PMF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 SMYD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 BMF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 TRIM54 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 PPP1R16B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 UBAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 ZMYND12 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 KRT35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 YPEL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 KRT39 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 CEACAM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 ASPG 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHC3 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SRC SHC3 16126371 27898060 N/A N/A OmniPath
NTRK2 SHC3 12074588 27898060 9507002 stimulant N/A OmniPath
EGFR SHC3 11791173 16273093 24212772 27898060 8760305 9507002 stimulant N/A OmniPath
SHC3 GRB2 12242309 16729043 16829981 27898060 stimulant N/A OmniPath
ERBB2 SHC3 16273093 16729043 27898060 stimulant N/A OmniPath
ERBB4 SHC3 16729043 16829981 27898060 stimulant N/A OmniPath
ALK SHC3 12185581 27898060 stimulant N/A OmniPath

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