GENE：SLIT2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLIT2 |
| FullNmae | slit guidance ligand 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11086 |
| EnsembleID | ENSG00000145147 |
| Uniprot | O94813 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLIT2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLIT2 | GO:0001657,GO:0001933,GO:0002042,GO:0002689,GO:0003180,GO:0003184,GO:0005095,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007411,GO:0008045,GO:0008201,GO:0008201,GO:0010593,GO:0010596,GO:0014912,GO:0016020,GO:0021836,GO:0021972,GO:0030308,GO:0030308,GO:0030336,GO:0030336,GO:0030837,GO:0031290,GO:0031290,GO:0032870,GO:0035385,GO:0035385,GO:0042802,GO:0042803,GO:0043065,GO:0043116,GO:0043237,GO:0043394,GO:0048495,GO:0048495,GO:0048754,GO:0048754,GO:0048846,GO:0050772,GO:0050919,GO:0050919,GO:0050919,GO:0050929,GO:0051058,GO:0051414,GO:0060412,GO:0061364,GO:0070062,GO:0070100,GO:0071504,GO:0071672,GO:0071676,GO:0090024,GO:0090027,GO:0090260,GO:0090288 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLIT2 | hsa:9353 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLIT2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | SLIT2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SLIT2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | SLIT2 | 19559773 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SLIT2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SLIT2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC5 | SLIT2 | 19351956 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBC | SLIT2 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | SLIT2 | 17314511 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| GPC1 | SLIT2 | 10364234 11375980 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| EXOSC4 | SLIT2 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | ROBO1 | 10102268 14525934 17848514 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| SLIT2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SLIT2 | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| SLIT2 | LUM | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | RSRC1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | EXOSC9 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | EXOSC7 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | EXOSC2 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| SLIT2 | ETS1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| SLIT2 | GPC1 | 10364234 11375980 27898060 | stimulant | N/A | OmniPath |