Gene Information gene info

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GENE：TEK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TEK
FullNmae TEK receptor tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11724
EnsembleID ENSG00000120156
Uniprot Q02763

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TEK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TEK GO:0001525,GO:0001525,GO:0001666,GO:0001725,GO:0001934,GO:0001934,GO:0001935,GO:0001935,GO:0001938,GO:0001958,GO:0002040,GO:0004672,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005884,GO:0005886,GO:0005886,GO:0005902,GO:0005911,GO:0005925,GO:0007165,GO:0007169,GO:0007169,GO:0007267,GO:0007275,GO:0007507,GO:0009925,GO:0009986,GO:0010595,GO:0010595,GO:0010595,GO:0016323,GO:0016324,GO:0016525,GO:0018108,GO:0019838,GO:0032878,GO:0033674,GO:0034446,GO:0034451,GO:0035556,GO:0038023,GO:0042802,GO:0043066,GO:0043114,GO:0043235,GO:0043410,GO:0043434,GO:0043552,GO:0043627,GO:0045121,GO:0045766,GO:0045766,GO:0045766,GO:0046777,GO:0048014,GO:0050728,GO:0051591,GO:0051894,GO:0051897,GO:0051897,GO:0051897,GO:0060216,GO:0060347,GO:0070374,GO:0070374,GO:0072012,GO:1902533,GO:2000351,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TEK hsa:7010 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
TEK hsa:7010 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
TEK hsa:7010 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
TEK hsa:7010 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
TEK hsa:7010 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
TEK hsa:7010 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPRB TEK 12237455 23180781 dephosphorylation reaction peptide array InnateDB
TNIP2 TEK 12609966 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TEK SHC1 14665640 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG TEK 20098747 23180781 physical association protein array InnateDB
ANGPT2 TEK 12427764 15893672 18988627 21071413 23331499 9204896 9723709 stimulation N/A SignaLink,SignaLink
ANGPT1 TEK 12427764 18988627 20937382 21071413 23331499 8980223 8980224 9204896 9723709 stimulation N/A SignaLink,SignaLink
ANGPT4 TEK 10051567 15284220 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
TEK TNIP2 12609966 23331499 stimulation N/A SignaLink,SignaLink
ANGPTL1 TEK 10051567 15284220 23331499 stimulation N/A SignaLink
TEK DOK2 11689432 23331499 9764820 stimulation N/A SignaLink
TEK GRAP 23331499 7478529 stimulation N/A SignaLink
TEK GRB7 10521483 23331499 stimulation N/A SignaLink
TEK GRB14 20973951 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DOK2 TEK 20005715 interaction type N/A PSP
DOK4 TEK 20005715 interaction type N/A PSP
GRB14 TEK 20005715 interaction type N/A PSP
GRB2 TEK 20005715 interaction type N/A PSP
GRB7 TEK 20005715 interaction type N/A PSP
PIK3R1 TEK 20005715 interaction type N/A PSP
SHC1 TEK 20005715 interaction type N/A PSP
SOCS1 TEK 20005715 interaction type N/A PSP
GRB2 TEK 20005715 N/A N/A SignaLink
GRB14 TEK 10521483 18988627 20005715 20005715 N/A N/A SignaLink
DOK2 TEK 18988627 20005715 20005715 9764820 N/A N/A SignaLink
DOK4 TEK 20005715 20005715 N/A N/A SignaLink
GRB7 TEK 10521483 18988627 20005715 20005715 N/A N/A SignaLink
SOCS1 TEK 10022833 18988627 20005715 20005715 N/A N/A SignaLink
PIK3R1 TEK 20005715 20005715 N/A N/A SignaLink
SHC1 TEK 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TEK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 TEK 19674970 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
CTCF TEK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TEK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TEK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ELF1 TEK 19674970 trascriptional regulation,stimulation inferred by curator TFlink
ELF2 TEK 10347098 trascriptional regulation,stimulation inferred by curator TFlink
EPAS1 TEK N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 TEK 22867989 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001D69F6 TEK 22867989 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TEK TEK 22135298 phosphorylation N/A PhosphoSite
GRB14 TEK 25361965 interaction type N/A PTMCode2
TEK GRB14 25361965 interaction type N/A PTMCode2
ANGPTL1 TEK 25361965 interaction type N/A PTMCode2
TEK ANGPTL1 25361965 interaction type N/A PTMCode2
ANGPT2 TEK 25361965 interaction type N/A PTMCode2
TEK ANGPT2 25361965 interaction type N/A PTMCode2
TNIP2 TEK 25361965 interaction type N/A PTMCode2
TEK TNIP2 25361965 interaction type N/A PTMCode2
GRB2 TEK 25361965 interaction type N/A PTMCode2
TEK GRB2 25361965 interaction type N/A PTMCode2
ANGPT4 TEK 25361965 interaction type N/A PTMCode2
TEK ANGPT4 25361965 interaction type N/A PTMCode2
DOK2 TEK 25361965 interaction type N/A PTMCode2
TEK DOK2 25361965 interaction type N/A PTMCode2
TEK SHC1 25361965 interaction type N/A PTMCode2
SHC1 TEK 25361965 interaction type N/A PTMCode2
PIK3R1 TEK 25361965 interaction type N/A PTMCode2
TEK PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R2 TEK 25361965 interaction type N/A PTMCode2
TEK PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CBL TEK 25348397 N/A physical interaction ComPPI
PTPN11 TEK 10521483 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PTPRO TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
SHC1 TEK 14525934 14665640 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down ComPPI,HPRD,IntAct
MAPK3 TEK 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TIE1 TEK 10995770 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PTPRB TEK 10557082 14525934 19167335 24234451 25348397 dephosphorylation reaction experimental interaction detection,phosphatase assay ComPPI,HPRD,IntAct
PTPRG TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRR TEK 25348397 N/A physical interaction ComPPI
PTPN12 TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PKM TEK 25348397 N/A protein kinase assay ComPPI
PTPRC TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TNIP2 TEK 12609966 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ANGPT1 TEK 12427764 14525934 20708158 24234451 25348397 8980223 8980224 9723709 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
ANGPT2 TEK 14525934 20708158 24234451 25348397 9723709 N/A cosedimentation in solution,dynamic light scattering,experimental interaction detection,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay ComPPI,HPRD,IntAct
ANGPT4 TEK 10051567 14525934 20708158 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
DOK2 TEK 14525934 25348397 9764820 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
AKT1 TEK 25348397 N/A physical interaction ComPPI
ILKAP TEK 25348397 N/A physical interaction ComPPI
STYX TEK 25348397 N/A physical interaction ComPPI
PTPRK TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
APP TEK 25348397 N/A physical interaction ComPPI
PTK2 TEK 25348397 N/A physical interaction ComPPI
IKBKG TEK 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PTPRJ TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEK DUSP18 25348397 N/A physical interaction ComPPI
TEK PIK3R1 10521483 14525934 N/A experimental interaction detection,two hybrid HPRD
TEK GRB2 10521483 14525934 7478529 N/A experimental interaction detection,two hybrid HPRD
TEK TEK 10521483 11080633 14525934 9632797 N/A experimental interaction detection HPRD
GRB7 TEK 10521483 14525934 N/A experimental interaction detection,two hybrid HPRD
GRB14 TEK 10521483 14525934 N/A experimental interaction detection,two hybrid HPRD
SOCS1 TEK 10022833 14525934 N/A two hybrid HPRD
ANGPTL1 TEK 10051567 14525934 N/A experimental interaction detection HPRD
STAT5A TEK 14525934 14726409 N/A experimental interaction detection HPRD
STAT5B TEK 14525934 14726409 N/A experimental interaction detection HPRD
TEK DOK4 11470823 14525934 N/A experimental interaction detection HPRD
IKBKG TEK 20098747 27898060 N/A N/A OmniPath
SHC1 TEK 14665640 27898060 N/A N/A OmniPath
TEK SHC1 14665640 27898060 stimulant N/A OmniPath
TEK GRB7 10521483 27898060 stimulant N/A OmniPath
TEK TNIP2 12609966 27898060 stimulant N/A OmniPath
ANGPT1 TEK 12427764 20708158 20937382 27898060 8980223 8980224 9204896 9723709 stimulant N/A OmniPath
PTPRB TEK 10557082 12237455 19116766 19167335 19451274 27898060 N/A N/A OmniPath
ANGPT2 TEK 12427764 15893672 16732286 20708158 27898060 9204896 9723709 stimulant N/A OmniPath
TEK GRAP 27898060 7478529 stimulant N/A OmniPath
TXK TEK 11080633 27898060 N/A N/A OmniPath
ANGPTL1 TEK 10051567 15284220 27898060 inhibition,stimulant N/A OmniPath
ANGPT4 TEK 10051567 15284220 20708158 27898060 stimulant N/A OmniPath

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