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GENE：TIAM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TIAM1
FullNmae TIAM Rac1 associated GEF 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11805
EnsembleID ENSG00000156299
Uniprot Q13009

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TIAM1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TIAM1 GO:0003300,GO:0005085,GO:0005085,GO:0005085,GO:0005085,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0005874,GO:0005886,GO:0005886,GO:0005911,GO:0007160,GO:0007264,GO:0008017,GO:0008284,GO:0008289,GO:0010717,GO:0010718,GO:0016477,GO:0016601,GO:0019900,GO:0030335,GO:0030971,GO:0032092,GO:0032587,GO:0042220,GO:0043025,GO:0043197,GO:0044291,GO:0044295,GO:0044304,GO:0045202,GO:0048013,GO:0050772,GO:0051056,GO:0060071,GO:0061003,GO:0061178,GO:0065003,GO:0070372,GO:0072657,GO:0090630,GO:0090630,GO:0098978,GO:0099147,GO:1904268,GO:1904338,GO:1905274,GO:1990138,GO:2000050

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TIAM1 hsa:7074 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa04530 Tight junction - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
TIAM1 hsa:7074 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TIAM1 RAC1 11955434 12447393 12829230 15611338 15967165 20841469 26192618 interaction type N/A ACSN
HRAS TIAM1 10358164 12134164 12447393 14764585 16102570 17673906 20841469 24027568 24954210 26192618 7510700 7673236 8551221 9069260 9763606 9846483 interaction type N/A ACSN
TIAM1 HRAS 12134164 23180781 physical association anti tag coimmunoprecipitation InnateDB
PARD3 TIAM1 17353362 23109003 24152735 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TIAM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TIAM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A TIAM1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 TIAM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C TIAM1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TIAM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TIAM1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TIAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D TIAM1 20826792 23442323 rna interference,inhibition array technology,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 TIAM1 20826792 rna interference,inhibition array technology,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D TIAM1 20826792 22815788 23442323 25416803 mrna cleavage,inhibition array technology,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000001EB3 TIAM1 20826792 25416803 mrna cleavage,inhibition array technology,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 TIAM1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 TIAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 TIAM1 24481854 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003E1A9 TIAM1 24551096 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 TIAM1 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000148B91 TIAM1 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000272A3D TIAM1 23142282 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000096022 TIAM1 23440286 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001CC379 TIAM1 25416803 25973950 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 TIAM1 22135298 phosphorylation N/A PhosphoSite
TIAM1 PRKCE 25361965 interaction type N/A PTMCode2
PRKCE TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 HRAS 25361965 interaction type N/A PTMCode2
HRAS TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 RAC1 25361965 interaction type N/A PTMCode2
RAC1 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 SRC 25361965 interaction type N/A PTMCode2
SRC TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 PARD3 25361965 interaction type N/A PTMCode2
PARD3 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 MYC 25361965 interaction type N/A PTMCode2
MYC TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ TIAM1 25361965 interaction type N/A PTMCode2
EFNB1 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 EFNB1 25361965 interaction type N/A PTMCode2
CD44 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 CD44 25361965 interaction type N/A PTMCode2
NME1 TIAM1 25361965 interaction type N/A PTMCode2
TIAM1 NME1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FAM110A TIAM1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
FAM53C TIAM1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAG TIAM1 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RAC1 TIAM1 11130063 11595749 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KBTBD7 TIAM1 25348397 N/A physical interaction ComPPI
CBY1 TIAM1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CD44 TIAM1 10636882 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HRAS TIAM1 12134164 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TIAM1 EPHA2 14525934 14988728 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TIAM1 PRKCA 10212259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TIAM1 PRKCE 10212259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TIAM1 PRKCD 10212259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TIAM1 PRKCG 10212259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TIAM1 ANK1 10893266 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TIAM1 MYC 12446731 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TIAM1 SRC 12810717 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TIAM1 EFNB1 14525934 14988728 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TIAM1 CAMK2G 25348397 N/A in vitro,in vivo ComPPI
TIAM1 PPP1R9B 12531897 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
TIAM1 MAPK8IP1 12024021 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TIAM1 MAPK8IP2 12024021 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TIAM1 PKHD1 25348397 N/A in vitro,in vivo ComPPI
TIAM1 PARD3 14525934 15723052 17053785 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TIAM1 ABCA1 14525934 16192287 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TIAM1 NME1 11274357 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TIAM1 PRKCB 25348397 N/A physical interaction ComPPI
TIAM1 PRKCZ 25348397 N/A physical interaction ComPPI
TIAM1 ANK3 25348397 N/A physical interaction ComPPI
TIAM1 NSD2 25348397 N/A physical interaction ComPPI
TIAM1 UBC 25348397 N/A physical interaction ComPPI
TIAM1 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIAM1 YWHAE 25348397 N/A physical interaction ComPPI
TIAM1 CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIAM1 BTRC 25348397 N/A physical interaction ComPPI
TIAM1 CSNK1A1 25348397 N/A physical interaction ComPPI
TIAM1 FBXW11 25348397 N/A physical interaction ComPPI
TIAM1 DARS1 25348397 N/A physical interaction ComPPI
TIAM1 KBTBD6 25348397 N/A physical interaction ComPPI
TIAM1 CTDSPL 25348397 N/A physical interaction ComPPI
TIAM1 KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 KIF13B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 ZBTB21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 GIGYF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SH3PXD2A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SRGAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 EIF4E2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SIPA1L1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 CGN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 RTKN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 MAGI1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 TESK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 ZNF638 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 AGAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 CDC25B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 CDK16 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 HDAC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 MAPKAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 FAM110B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 ANKRD34A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 NADK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 CAMSAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 MAP3K21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 RASAL2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 GIGYF2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 PHLDB2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 PLEKHA7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 KIF1C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 INPP5E 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TIAM1 SDC1 23395182 24234451 25348397 N/A classical fluorescence spectroscopy,isothermal titration calorimetry,nuclear magnetic resonance,x-ray crystallography,physical interaction ComPPI,IntAct
TIAM1 CNTNAP4 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,physical interaction ComPPI
TIAM1 SDC2 23395182 24234451 25348397 N/A classical fluorescence spectroscopy,physical interaction ComPPI,IntAct
TIAM1 SDC3 23395182 24234451 25348397 N/A classical fluorescence spectroscopy,physical interaction ComPPI,IntAct
TIAM1 SDC4 23395182 24234451 25348397 N/A classical fluorescence spectroscopy,physical interaction ComPPI,IntAct
TIAM1 IGHA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TIAM1 IGHM 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TIAM1 YWHAH 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TIAM1 CASK 21763699 24234451 25348397 physical association blue native page ComPPI,IntAct
CSNK1E TIAM1 25348397 N/A physical interaction ComPPI
TIAM1 TIAM1 12376551 14525934 14988728 N/A experimental interaction detection HPRD
SRC TIAM1 12810717 27898060 stimulant N/A OmniPath
HRAS TIAM1 12134164 18568040 27898060 stimulant N/A OmniPath
AKT1 TIAM1 25746002 27898060 N/A N/A OmniPath
TIAM1 RAC1 10212259 11130063 11595749 12393875 27898060 stimulant N/A OmniPath
SMO TIAM1 20654717 23074268 27898060 stimulant N/A OmniPath
MAPK8IP1 TIAM1 12024021 27898060 stimulant N/A OmniPath
CAMK2A TIAM1 10212259 27898060 stimulant N/A OmniPath

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