Gene Information gene info

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GENE：VEGFC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VEGFC
FullNmae vascular endothelial growth factor C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12682
EnsembleID ENSG00000150630
Uniprot P49767

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VEGFC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VEGFC GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0002052,GO:0005515,GO:0005576,GO:0005615,GO:0006929,GO:0007165,GO:0008083,GO:0008284,GO:0009410,GO:0009887,GO:0014009,GO:0016020,GO:0016331,GO:0030947,GO:0031093,GO:0031954,GO:0038084,GO:0042056,GO:0042056,GO:0043185,GO:0043185,GO:0043536,GO:0045668,GO:0045766,GO:0045776,GO:0048010,GO:0048010,GO:0050714,GO:0050918,GO:0050930,GO:0050930,GO:0051781,GO:0060252,GO:0060754,GO:0060754,GO:1901492,GO:1902462,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VEGFC hsa:7424 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04510 Focal adhesion - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
VEGFC hsa:7424 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
VEGFC hsa:7424 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT3 VEGFC 23180781 25733697 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR VEGFC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 VEGFC 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 VEGFC 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 VEGFC 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VEGFC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX2 VEGFC 22641097 trascriptional regulation,stimulation inferred by curator TFlink
SIX1 VEGFC 22466647 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 VEGFC N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A VEGFC N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000330617 VEGFC 23593282 25416803 26460960 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000065FDF VEGFC 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001938D9 VEGFC 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CD810 VEGFC 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F VEGFC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC VEGFC 25416803 27508026 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
KDR VEGFC 25361965 interaction type N/A PTMCode2
VEGFC KDR 25361965 interaction type N/A PTMCode2
FLT4 VEGFC 25361965 interaction type N/A PTMCode2
VEGFC FLT4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTB VEGFC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KDR VEGFC 11332691 14525934 20145116 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,light scattering,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
FLT4 VEGFC 14525934 16530705 21130043 24234451 25348397 8700872 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,solid phase assay ComPPI,HPRD,IntAct
VEGFC VEGFC 14525934 9233800 N/A experimental interaction detection HPRD
VEGFC KDR 11332691 20145116 27898060 9435229 stimulant N/A OmniPath
VEGFC FLT4 12881528 16530705 21130043 27898060 8700872 9435229 stimulant N/A OmniPath
NRP2 VEGFC 16816121 27898060 stimulant N/A OmniPath
VEGFC NRP2 16816121 27898060 stimulant N/A OmniPath

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