GENE：MAML2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAML2 |
| FullNmae | mastermind like transcriptional coactivator 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16259 |
| EnsembleID | ENSG00000184384 |
| Uniprot | Q8IZL2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAML2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAML2 | GO:0003713,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0007219,GO:0007221,GO:0016607,GO:0045944 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAML2 | hsa:84441 | path:hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| MAML2 | hsa:84441 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| MAML2 | hsa:84441 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAML2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MAML2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MAML2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MAML2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | MAML2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MAML2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | MAML2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MAML2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOTCH1 | MAML2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAML2 | NOTCH1 | 25361965 | interaction type | N/A | PTMCode2 |
| NOTCH3 | MAML2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAML2 | NOTCH3 | 25361965 | interaction type | N/A | PTMCode2 |
| MAML1 | MAML2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAML2 | MAML1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOTCH4 | MAML2 | 12370315 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MAML1 | MAML2 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH1 | MAML2 | 12370315 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CREBBP | MAML2 | 14525934 15961999 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| EP300 | MAML2 | 25348397 | N/A | physical interaction | ComPPI |
| MAML2 | NOTCH2 | 12370315 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MAML2 | NOTCH3 | 12370315 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MAML2 | DIABLO | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MAML2 | RBPJ | 25348397 | N/A | physical interaction | ComPPI |
| RBPJ | MAML2 | 21873209 27898060 | stimulant | N/A | OmniPath |
| MAML2 | NOTCH1 | 12370315 27898060 | stimulant | N/A | OmniPath |
| MAML2 | NOTCH2 | 12370315 27898060 | stimulant | N/A | OmniPath |
| MAML2 | NOTCH3 | 12370315 27898060 | stimulant | N/A | OmniPath |
| MAML2 | NOTCH4 | 12370315 27898060 | stimulant | N/A | OmniPath |
| NOTCH4 | MAML2 | 12370315 12386158 27898060 | stimulant | N/A | OmniPath |