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GENE：PAK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAK3
FullNmae p21 (RAC1) activated kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8592
EnsembleID ENSG00000077264
Uniprot O75914

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAK3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAK3 GO:0000165,GO:0002223,GO:0004674,GO:0004674,GO:0004674,GO:0004708,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007409,GO:0014069,GO:0016310,GO:0016358,GO:0017124,GO:0030833,GO:0031267,GO:0032956,GO:0035556,GO:0043408,GO:0046872,GO:0048013,GO:0050770,GO:0050808,GO:0060997,GO:0060997,GO:0071407,GO:0098978,GO:0099175,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAK3 hsa:5063 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PAK3 hsa:5063 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PAK3 hsa:5063 path:hsa04360 Axon guidance - Homo sapiens (human)
PAK3 hsa:5063 path:hsa04510 Focal adhesion - Homo sapiens (human)
PAK3 hsa:5063 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PAK3 hsa:5063 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PAK3 hsa:5063 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
PAK3 hsa:5063 path:hsa05132 Salmonella infection - Homo sapiens (human)
PAK3 hsa:5063 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PAK3 hsa:5063 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAK3 RAF1 10461188 10559936 10613909 10712905 11340065 11413130 11950587 26192618 9069260 9823899 interaction type N/A ACSN
NCK1 PAK3 11278553 23180781 physical association anti tag coimmunoprecipitation InnateDB
PAK3 CDC42 10866202 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPA PAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PAK3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005C1F22 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A PAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC42 PAK3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RAC1 PAK3 11862216 24234451 25348397 physical association fluorescent resonance energy transfer,pull down,physical interaction ComPPI,IntAct
NCK1 PAK3 11278553 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK14 PAK3 25348397 N/A physical interaction ComPPI
SYN1 PAK3 12237306 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GIT1 PAK3 10896954 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PLK1 PAK3 20869364 24234451 25348397 physical association pull down ComPPI,IntAct
PXN PAK3 25348397 N/A in vitro ComPPI
HNRNPL PAK3 25348397 N/A physical interaction ComPPI
ABCE1 PAK3 25348397 N/A physical interaction ComPPI
ITSN1 PAK3 25348397 N/A physical interaction ComPPI
RAF1 PAK3 10205168 11733498 14525934 25348397 9234708 9823899 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STK4 PAK3 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PAK3 ARHGEF6 14525934 25348397 9659915 N/A experimental interaction detection,in vivo ComPPI,HPRD
PAK3 MYO6 11517222 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PAK3 ARHGEF7 14525934 25348397 9726964 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PAK3 GIT2 10896954 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PAK3 SNCA 25348397 N/A physical interaction ComPPI
SNRNP27 PAK3 25348397 N/A physical interaction ComPPI
PAK3 PAK3 11278486 14525934 N/A experimental interaction detection HPRD
PAK3 TNNI3 11121119 12242269 15769444 27898060 8543035 inhibition N/A OmniPath
PAK3 MYO6 11517222 20068231 27898060 stimulant N/A OmniPath
PAK3 RAF1 10205168 11733498 27898060 9234708 9823899 stimulant N/A OmniPath
PAK3 CDC42 10866202 11157984 15824104 20936779 27898060 stimulant N/A OmniPath
PAK3 CALD1 20858431 27898060 inhibition N/A OmniPath

Visualization










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