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GENE：UCK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UCK2
FullNmae uridine-cytidine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12562
EnsembleID ENSG00000143179
Uniprot Q9BZX2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UCK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UCK2 GO:0004849,GO:0005524,GO:0005575,GO:0005737,GO:0005829,GO:0009224,GO:0016310,GO:0042802,GO:0043771,GO:0044206,GO:0044206,GO:0044211,GO:0044211

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UCK2 hsa:7371 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
UCK2 hsa:7371 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
UCK2 hsa:7371 path:hsa01100 Metabolic pathways - Homo sapiens (human)
UCK2 hsa:7371 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR UCK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 UCK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 UCK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 UCK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 UCK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 UCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 UCK2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 UCK2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000CF1D2 UCK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000029EBD UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F7766 UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002AB575 UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000195F5B UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001E0AEA UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E226A UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000519450 UCK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CC0F4 UCK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C UCK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 UCK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 UCK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 UCK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA UCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KEAP1 UCK2 25348397 N/A physical interaction ComPPI
UBC UCK2 25348397 N/A physical interaction ComPPI
DLD UCK2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EGFR UCK2 25348397 N/A physical interaction ComPPI
VCAM1 UCK2 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
TRIM25 UCK2 25348397 N/A physical interaction ComPPI
NEK6 UCK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UCK2 FBXO6 25348397 N/A physical interaction ComPPI
UCK2 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct

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