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GENE：ALOX5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ALOX5
FullNmae arachidonate 5-lipoxygenase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:435
EnsembleID ENSG00000012779
Uniprot P09917

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ALOX5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ALOX5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ALOX5 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ALOX5 GO:0001937,GO:0002232,GO:0002523,GO:0002540,GO:0004051,GO:0004051,GO:0004051,GO:0004052,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005635,GO:0005635,GO:0005635,GO:0005641,GO:0005654,GO:0005829,GO:0005829,GO:0006691,GO:0006959,GO:0016363,GO:0016525,GO:0016787,GO:0019369,GO:0019370,GO:0019372,GO:0019372,GO:0030501,GO:0031965,GO:0034440,GO:0034774,GO:0036336,GO:0036403,GO:0042593,GO:0042759,GO:0043651,GO:0045598,GO:0048471,GO:0050727,GO:0050728,GO:0050796,GO:0051122,GO:0061044,GO:0061045,GO:0106014,GO:1900015,GO:1900407,GO:1901753,GO:1901753,GO:1903426,GO:1903573,GO:1903671,GO:1904813,GO:1904999,GO:2001301

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ALOX5 hsa:240 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
ALOX5 hsa:240 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ALOX5 hsa:240 path:hsa04148 Efferocytosis - Homo sapiens (human)
ALOX5 hsa:240 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
ALOX5 hsa:240 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
ALOX5 hsa:240 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
ALOX5 hsa:240 path:hsa05145 Toxoplasmosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NLRP10 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
APEX1 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
IKZF3 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
ZNF433 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
HSD17B4 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
ALOX5 LTC4S 19233132 23180781 physical association pull down InnateDB
ALOX5AP ALOX5 19233132 23180781 physical association pull down InnateDB
COTL1 ALOX5 16924104 23180781 physical association pull down InnateDB
ALOX5 MEOX1 23180781 25416956 physical association two hybrid InnateDB
ALOX5 REL 23180781 25416956 physical association two hybrid InnateDB
ALOX5 MAD1L1 23180781 25416956 physical association two hybrid InnateDB
ALOX5 HHIPL2 23180781 25416956 physical association two hybrid InnateDB
ALOX5 CEP63 23180781 25416956 physical association two hybrid InnateDB
ALOX5 SYCE1 23180781 25416956 physical association two hybrid InnateDB
ALOX5 CEP57L1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
EGR1 ALOX5 10436859 15517885 18971253 9062372 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP1 ALOX5 10436859 19781662 2251250 9062372 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
VDR ALOX5 19837082 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
PRDM14 ALOX5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ALOX5 17018618 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ALOX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 ALOX5 21883892 trascriptional regulation,stimulation inferred by curator TFlink
HDAC3 ALOX5 21883892 trascriptional regulation,stimulation inferred by curator TFlink
MBD1 ALOX5 19781662 trascriptional regulation,stimulation inferred by curator TFlink
MBD2 ALOX5 19781662 trascriptional regulation,stimulation inferred by curator TFlink
MECP2 ALOX5 19781662 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ALOX5 15517885 trascriptional regulation,stimulation inferred by curator TFlink
RELA ALOX5 15517885 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ALOX5 10436859 19781662 2251250 9062372 trascriptional regulation,stimulation inferred by curator TFlink
MYB ALOX5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000006FDD4 ALOX5 25416803 25589070 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2A ALOX5 22135298 phosphorylation N/A PhosphoSite
MAPKAPK2 ALOX5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKACA ALOX5 22135298 phosphorylation N/A PhosphoSite
MAPK1 ALOX5 22135298 phosphorylation N/A PhosphoSite
ALOX5 MAPKAPK2 25361965 interaction type N/A PTMCode2
COTL1 ALOX5 25361965 interaction type N/A PTMCode2
ALOX5 COTL1 25361965 interaction type N/A PTMCode2
GRB2 ALOX5 25361965 interaction type N/A PTMCode2
ALOX5 GRB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 ALOX5 24234451 24860872 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PALS1 ALOX5 25348397 N/A physical interaction ComPPI
TBC1D7 ALOX5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TPP2 ALOX5 25348397 N/A physical interaction ComPPI
AMOT ALOX5 25348397 N/A physical interaction ComPPI
ACTB ALOX5 14525934 25348397 7929073 N/A experimental interaction detection,in vitro ComPPI,HPRD
COTL1 ALOX5 10051563 11297527 14525934 16924104 19807693 24234451 25348397 27898060 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
ARMCX5 ALOX5 25348397 N/A physical interaction ComPPI
REL ALOX5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIK3R1 ALOX5 25348397 N/A physical interaction ComPPI
GRB2 ALOX5 14525934 25348397 27898060 7929073 8585605 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CDC16 ALOX5 25348397 N/A physical interaction ComPPI
PRKACA ALOX5 24234451 24860872 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MEOX1 ALOX5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPS6KA2 ALOX5 25348397 N/A physical interaction ComPPI
RELA ALOX5 25348397 N/A physical interaction ComPPI
CAMK2G ALOX5 24234451 24860872 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PNPLA2 ALOX5 25348397 N/A physical interaction ComPPI
ITSN1 ALOX5 25348397 N/A physical interaction ComPPI
ALOX5 ALOX5AP 14525934 25348397 9445303 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ALOX5 TGFBRAP1 10051563 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ALOX5 MAPKAPK2 10779545 11844797 14525934 24234451 24860872 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
ALOX5 APP 25348397 N/A physical interaction ComPPI
ALOX5 LTC4S 25348397 N/A physical interaction ComPPI
ALOX5 DICER1 10051563 19022417 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ALOX5 MAD1L1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
ALOX5 CEP63 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALOX5 SYCE1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
ALOX5 NUTM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ALOX5 CEP57L1 25348397 N/A physical interaction ComPPI
ALOX5 ALPL 25348397 N/A physical interaction ComPPI
ALOX5 SLAIN1 25348397 N/A physical interaction ComPPI
ALOX5 TBC1D2B 25348397 N/A physical interaction ComPPI
ALOX5 LSS 25348397 N/A physical interaction ComPPI
ALOX5 KDM3B 25348397 N/A physical interaction ComPPI
ALOX5 NCSTN 25348397 N/A physical interaction ComPPI
ALOX5 OSBPL11 25348397 N/A physical interaction ComPPI
ALOX5 CKAP5 25348397 N/A physical interaction ComPPI
ALOX5 RNF6 25348397 N/A physical interaction ComPPI
ALOX5 CAMKK2 25348397 N/A physical interaction ComPPI
ALOX5 MND1 25348397 N/A physical interaction ComPPI
ALOX5 MTMR4 25348397 N/A physical interaction ComPPI
ALOX5 DDHD2 25348397 N/A physical interaction ComPPI
ALOX5 RAB3GAP1 25348397 N/A physical interaction ComPPI
ALOX5 KIF16B 25348397 N/A physical interaction ComPPI
ALOX5 DMWD 25348397 N/A physical interaction ComPPI
ALOX5 TRIM65 25348397 N/A physical interaction ComPPI
ALOX5 ERCC6L 25348397 N/A physical interaction ComPPI
ALOX5 PMF1 25348397 N/A physical interaction ComPPI
ALOX5 MTMR3 25348397 N/A physical interaction ComPPI
ALOX5 TEDC1 25348397 N/A physical interaction ComPPI
ALOX5 ADSL 25348397 N/A physical interaction ComPPI
ALOX5 COG2 25348397 N/A physical interaction ComPPI
ALOX5 AMOTL1 25348397 N/A physical interaction ComPPI
ALOX5 NFKB2 25348397 N/A physical interaction ComPPI
ALOX5 ERMP1 25348397 N/A physical interaction ComPPI
ALOX5 MADD 25348397 N/A physical interaction ComPPI
ALOX5 NEU3 25348397 N/A physical interaction ComPPI
ALOX5 HCK 24234451 24860872 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
ALOX5 FGR 24234451 24860872 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
ALOX5 CCDC174 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALOX5 HSD17B1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALOX5 LCN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALOX5 OOEP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMF1 ALOX5 25348397 N/A physical interaction ComPPI
GATC ALOX5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HHIPL2 ALOX5 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
PRKACA ALOX5 10779545 11844797 12205041 12670876 15280375 16165096 16230355 18978352 24860872 26173130 26210919 27898060 N/A N/A OmniPath
MAPKAPK2 ALOX5 10779545 11844797 18978352 24860872 27898060 N/A N/A OmniPath
CAMK2A ALOX5 11844797 27898060 N/A N/A OmniPath
CSK ALOX5 11844797 15280375 16230355 27898060 N/A N/A OmniPath

Visualization










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