GENE：ASCL1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ASCL1 |
| FullNmae | achaete-scute family bHLH transcription factor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:738 |
| EnsembleID | ENSG00000139352 |
| Uniprot | P50553 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ASCL1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ASCL1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ASCL1 | GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0003358,GO:0003359,GO:0003676,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0007219,GO:0007346,GO:0007400,GO:0007405,GO:0007423,GO:0007507,GO:0010468,GO:0014003,GO:0021527,GO:0021530,GO:0021750,GO:0021892,GO:0021902,GO:0021954,GO:0021987,GO:0022008,GO:0030182,GO:0030182,GO:0030856,GO:0032526,GO:0042802,GO:0043025,GO:0043066,GO:0043425,GO:0043525,GO:0045665,GO:0045666,GO:0045747,GO:0045787,GO:0045892,GO:0045944,GO:0045944,GO:0046983,GO:0048469,GO:0048485,GO:0048663,GO:0048665,GO:0048666,GO:0048935,GO:0050767,GO:0050769,GO:0050883,GO:0051593,GO:0060163,GO:0060165,GO:0060166,GO:0060487,GO:0060579,GO:0061100,GO:0061102,GO:0061103,GO:0061104,GO:0061549,GO:0070849,GO:0070888,GO:0071259,GO:0090575,GO:0097475,GO:1990837,GO:2000179 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HES1 | ASCL1 | 11054669 21573214 9144241 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| YBX1 | ASCL1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | ASCL1 | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ASCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATD3B | ASCL1 | 11054669 21573214 9144241 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HES6 | ASCL1 | 16103883 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNRNPR | ASCL1 | 25124043 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LMO3 | ASCL1 | 21573214 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NHLH2 | ASCL1 | 21573214 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237CBD | ASCL1 | 23884650 25416803 | mrna cleavage,inhibition | experimental interaction detection,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunohistochemistry,immunocytochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00003003B4 | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005194EC | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A4ABF | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AFAD1 | ASCL1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EP300 | ASCL1 | 11564735 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| UBQLN2 | ASCL1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MEF2C | ASCL1 | 25348397 | N/A | physical interaction | ComPPI |
| MEF2D | ASCL1 | 25348397 | N/A | physical interaction | ComPPI |
| MEF2A | ASCL1 | 14525934 25348397 27898060 8662987 8900141 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| BMP2 | ASCL1 | 14525934 25348397 27898060 9197246 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| MTNR1A | ASCL1 | 24234451 25348397 26514267 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| UBQLN1 | ASCL1 | 14525934 15492808 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ASCL1 | NEUROG2 | 14525934 25348397 8948587 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| ASCL1 | TCF4 | 10903890 14525934 24234451 25348397 | physical association | two hybrid,experimental interaction detection,pull down,physical interaction,electrophoretic mobility shift assay,two hybrid | ComPPI,HPRD,IntAct |
| ASCL1 | TCF3 | 10903890 24234451 25348397 | physical association | two hybrid,pull down | ComPPI,IntAct |
| ASCL1 | ASCL1 | 14525934 8900141 8948587 | N/A | experimental interaction detection,two hybrid | HPRD |
| CDK1 | ASCL1 | 12695666 21098119 21658602 24186061 27898060 | N/A | N/A | OmniPath |
| DTX1 | ASCL1 | 11564735 27898060 | inhibition | N/A | OmniPath |