GENE:KDM4B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KDM4B |
| FullNmae | lysine demethylase 4B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29136 |
| EnsembleID | ENSG00000127663 |
| Uniprot | O94953 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KDM4B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KDM4B | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KDM4B | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KDM4B | GO:0000785,GO:0005634,GO:0005654,GO:0006338,GO:0007420,GO:0010468,GO:0032452,GO:0032454,GO:0032454,GO:0032454,GO:0046872,GO:0051864,GO:0140684 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KDM4B | 18971253 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | KDM4B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | KDM4B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | KDM4B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | KDM4B | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| YBX1 | KDM4B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | KDM4B | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | KDM4B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | KDM4B | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000017EA6A | KDM4B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000600E6 | KDM4B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | KDM4B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001919B0 | KDM4B | 25416803 25725194 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| H2BC4 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | KDM4B | 22373579 24234451 25348397 | N/A | isothermal titration calorimetry | ComPPI,IntAct |
| KMT2D | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| HSP90B1 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| ASH2L | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPU | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| UHRF2 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| RBBP5 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| TCP1 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| CCT5 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| CCT7 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| HSPA4 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| SF1 | KDM4B | 24234451 25348397 26420826 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| DDX3X | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| ESR1 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| SNU13 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| CCT4 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| CCT2 | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| CCT6A | KDM4B | 25348397 | N/A | physical interaction | ComPPI |
| MED10 | KDM4B | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| KDM4B | SMU1 | 25348397 | N/A | physical interaction | ComPPI |
| KDM4B | H2BC11 | 25348397 | N/A | physical interaction | ComPPI |
| KDM4B | KDM4A | 25348397 | N/A | physical interaction | ComPPI |
| KDM4B | CCT3 | 25348397 | N/A | physical interaction | ComPPI |
| KDM4B | CCT8 | 25348397 | N/A | physical interaction | ComPPI |
| KDM4B | H3C1 | 18022353 27898060 | inhibition | N/A | OmniPath |
