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GENE：ITPR3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITPR3
FullNmae inositol 1,4,5-trisphosphate receptor type 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6182
EnsembleID ENSG00000096433
Uniprot Q14573

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITPR3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITPR3 GO:0000822,GO:0005220,GO:0005220,GO:0005220,GO:0005509,GO:0005515,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005789,GO:0005789,GO:0005886,GO:0005886,GO:0005903,GO:0007186,GO:0007204,GO:0007613,GO:0015278,GO:0015278,GO:0016020,GO:0016529,GO:0030667,GO:0031095,GO:0035091,GO:0043025,GO:0043209,GO:0043235,GO:0043533,GO:0045177,GO:0050909,GO:0050913,GO:0050916,GO:0050917,GO:0051209,GO:0051592,GO:0055074,GO:0060291,GO:0070679,GO:0070679,GO:0098554

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITPR3 hsa:3710 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04210 Apoptosis - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04218 Cellular senescence - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04540 Gap junction - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04611 Platelet activation - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04713 Circadian entrainment - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04720 Long-term potentiation - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04730 Long-term depression - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04742 Taste transduction - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04911 Insulin secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04924 Renin secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04929 GnRH secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04934 Cushing syndrome - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04970 Salivary secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05012 Parkinson disease - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05020 Prion disease - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05131 Shigellosis - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
ITPR3 hsa:3710 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HSP90B1 ITPR3 19147678 23180781 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
AHCYL1 ITPR3 11904675 16754674 29145629 physical association inferred by curator Reactome
ITPR2 ITPR3 17429043 24243840 29145629 physical association inferred by curator Reactome
ITPR3 ITPR3 17429043 24243840 29145629 physical association inferred by curator Reactome
ITPR3 ITPR1 17429043 24243840 29145629 physical association inferred by curator Reactome
STIM1 ITPR3 18187424 18596693 19249086 29145629 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
ETS1 ITPR3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITPR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB ITPR3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D ITPR3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED ITPR3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C ITPR3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SNAP29 ITPR3 25348397 N/A physical interaction ComPPI
VCP ITPR3 25348397 N/A physical interaction ComPPI
DPPA4 ITPR3 25348397 N/A physical interaction ComPPI
TAFA4 ITPR3 25348397 N/A physical interaction ComPPI
GRB2 ITPR3 12577067 24234451 25348397 association pull down ComPPI,IntAct
FLNA ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRPC1 ITPR3 10980191 11290752 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
VAPA ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCD1 ITPR3 25348397 N/A physical interaction ComPPI
TRPC3 ITPR3 10611319 11524429 14525934 15623527 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
CAV1 ITPR3 25348397 N/A physical interaction ComPPI
PPP1CA ITPR3 19389623 24234451 25348397 N/A pull down ComPPI,IntAct
TRPC6 ITPR3 10611319 11290752 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PTEN ITPR3 25348397 N/A physical interaction ComPPI
ATP2A1 ITPR3 25348397 N/A physical interaction ComPPI
ATP2A2 ITPR3 22045338 24234451 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
LRPPRC ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRPC5 ITPR3 11290752 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TRPC4 ITPR3 11163362 11290752 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
TRIM25 ITPR3 25348397 N/A physical interaction ComPPI
MTNR1A ITPR3 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
AKT1 ITPR3 25348397 N/A physical interaction ComPPI
FBXL2 ITPR3 25348397 N/A physical interaction ComPPI
SYNPO ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANLN ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITPR1 ITPR3 14525934 25348397 27898060 7559486 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ACTR2 ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB29 ITPR3 25348397 N/A physical interaction ComPPI
MYH9 ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRPC7 ITPR3 25348397 N/A physical interaction ComPPI
CHRNA3 ITPR3 25348397 N/A physical interaction ComPPI
L3MBTL2 ITPR3 25348397 N/A physical interaction ComPPI
PCGF1 ITPR3 25348397 N/A physical interaction ComPPI
POU5F1 ITPR3 25348397 N/A physical interaction ComPPI
LIMA1 ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT7 ITPR3 25348397 N/A physical interaction ComPPI
BBOX1 ITPR3 25348397 N/A physical interaction ComPPI
MTNR1B ITPR3 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
SIGMAR1 ITPR3 11149946 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CAPZA2 ITPR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITPR3 OBSL1 25348397 N/A physical interaction ComPPI
ITPR3 CCDC8 25348397 N/A physical interaction ComPPI
ITPR3 TESPA1 25348397 N/A physical interaction ComPPI
ITPR3 FGL2 25348397 N/A physical interaction ComPPI
ITPR3 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITPR3 NANOGP8 25348397 N/A physical interaction ComPPI
ITPR3 NANOG 25348397 N/A physical interaction ComPPI
ITPR3 CTDNEP1 25348397 N/A physical interaction ComPPI
ITPR3 FRMD1 25348397 N/A physical interaction ComPPI
ANK1 ITPR3 14525934 15051494 27898060 8385102 N/A experimental interaction detection HPRD,OmniPath
TRPM2 ITPR3 11290752 14525934 N/A experimental interaction detection HPRD
CABP1 ITPR3 12032348 14525934 14685260 N/A experimental interaction detection HPRD
BAP1 ITPR3 24234451 28614305 deubiquitination reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy,proximity ligation assay,deubiquitinase assay IntAct
RPS11 ITPR3 24234451 30021884 physical association cross-linking study IntAct
PHB2 ITPR3 24234451 30021884 physical association cross-linking study IntAct
KRT8 ITPR3 24234451 30021884 physical association cross-linking study IntAct
UBC ITPR3 10191279 21071436 27898060 9139693 N/A N/A OmniPath
ITPR3 TRPV4 18378772 18826956 27898060 stimulant N/A OmniPath
ITPR3 TRPC3 10611319 11248050 11290752 11524429 15623527 16887806 27898060 stimulant N/A OmniPath
ITPR3 HSP90B1 19147678 27898060 N/A N/A OmniPath

Visualization










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