GENE：CLIC4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CLIC4 |
| FullNmae | chloride intracellular channel 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:13518 |
| EnsembleID | ENSG00000169504 |
| Uniprot | Q9Y696 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CLIC4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CLIC4 | GO:0001525,GO:0001886,GO:0005244,GO:0005254,GO:0005515,GO:0005737,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0005902,GO:0005911,GO:0006821,GO:0006821,GO:0007035,GO:0009566,GO:0009986,GO:0015629,GO:0015630,GO:0016020,GO:0016363,GO:0030154,GO:0030216,GO:0030336,GO:0030496,GO:0030659,GO:0034707,GO:0034765,GO:0035088,GO:0035264,GO:0045177,GO:0048471,GO:0048754,GO:0051493,GO:0061299,GO:0070062,GO:0071277,GO:1902476 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CLIC4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | CLIC4 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | CLIC4 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CLIC4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000AA464 | CLIC4 | 21512034 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000237AF9 | CLIC4 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000338542 | CLIC4 | 20584899 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00001E0AEA | CLIC4 | 17612493 22473208 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS00003380CC | CLIC4 | 17612493 20371350 21572407 23793894 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS000016D2D4 | CLIC4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002C0FCB | CLIC4 | 22012620 23446348 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS000006FDD4 | CLIC4 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | CLIC4 | 20371350 21572407 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023BE29 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B0F6 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C48FA | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | CLIC4 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CD810 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000458AD2 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000011A030 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000057FDB8 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039607D | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077AED | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDA4 | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | CLIC4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | CLIC4 | 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237E04 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000E601 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | CLIC4 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB16 | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000605E00 | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048F59D | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCDA3 | CLIC4 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RABIF | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CDA | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| LSM3 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| ACTB | CLIC4 | 11563969 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| HSP90AB1 | CLIC4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| HNRNPH2 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| REL | CLIC4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CRKL | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| SHC1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMA3 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | CLIC4 | 11563969 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| NTRK1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| DNM1 | CLIC4 | 11563969 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| P4HB | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMA1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMA5 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| ST13 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| NDRG1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CSK | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| UBA2 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CDK2 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| FDPS | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC2 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| PDCD6 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC5 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| DDB1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | SPRTN | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | CLIC6 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | TPRN | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | ACADS | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | EZR | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | HADH | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | HIBCH | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | PSMA2 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | PSMB7 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | SUGT1 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | TAGLN2 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | TAGLN3 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | TPD52 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | COASY | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | DNAJC9 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | SEPHS1 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | ST13P4 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | ICAM1 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | G3BP1 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC4 | MCC | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CLIC4 | MAIP1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PSMB4 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMB1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| MAPT | CLIC4 | 24234451 26402096 | association | anti bait coimmunoprecipitation | IntAct |