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GENE：EGR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EGR2
FullNmae early growth response 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3239
EnsembleID ENSG00000122877
Uniprot P11161

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EGR2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EGR2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EGR2 GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006357,GO:0006611,GO:0007420,GO:0007422,GO:0007611,GO:0007622,GO:0008045,GO:0010467,GO:0014037,GO:0014040,GO:0016925,GO:0016925,GO:0021612,GO:0021659,GO:0021660,GO:0021665,GO:0021666,GO:0030278,GO:0031625,GO:0031643,GO:0032868,GO:0035284,GO:0035904,GO:0035914,GO:0042552,GO:0043231,GO:0043565,GO:0045444,GO:0045893,GO:0045944,GO:0045944,GO:0046872,GO:0048168,GO:0061629,GO:0061665,GO:0071310,GO:0071837,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EGR2 hsa:1959 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
EGR2 hsa:1959 path:hsa05161 Hepatitis B - Homo sapiens (human)
EGR2 hsa:1959 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
EGR2 hsa:1959 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR2 BAK1 12687019 26192618 interaction type N/A ACSN
EGR3 EGR2 19915002 23180781 physical association electrophoretic mobility supershift assay InnateDB
EGR1 EGR2 19032775 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 EGR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EGR2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EGR2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 EGR2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 EGR2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 EGR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EWSR1 EGR2 22327514 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 EGR2 18924150 trascriptional regulation,stimulation inferred by curator TFlink
SCD5 EGR2 22510410 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000016FD1A EGR2 20067763 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000016FD1A EGR2 20067763 23604034 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001A405B EGR2 19396866 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00002C0FCB EGR2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 EGR2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001E0AEA EGR2 23602969 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS0000042E1F EGR2 23924943 25416803 26238942 mrna cleavage,inhibition experimental interaction detection,western blot,detection by mass spectrometry,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002075FA EGR2 25416803 27725906 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007A060 EGR2 25416803 25935837 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
EGR2 NAB2 25361965 interaction type N/A PTMCode2
NAB2 EGR2 25361965 interaction type N/A PTMCode2
EGR2 HCFC1 25361965 interaction type N/A PTMCode2
HCFC1 EGR2 25361965 interaction type N/A PTMCode2
EGR2 NAB1 25361965 interaction type N/A PTMCode2
NAB1 EGR2 25361965 interaction type N/A PTMCode2
EGR2 SOX10 25361965 interaction type N/A PTMCode2
SOX10 EGR2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I EGR2 21836637 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SNAI1 EGR2 25348397 N/A physical interaction ComPPI
NFATC1 EGR2 25348397 N/A physical interaction ComPPI
HCFC1 EGR2 14525934 14532282 24234451 25348397 27898060 physical association experimental interaction detection,physical interaction,transcriptional complementation assay,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
ACP5 EGR2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WWP2 EGR2 19651900 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SOX8 EGR2 14525934 16582099 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DTX1 EGR2 25348397 N/A physical interaction ComPPI
DNMT3L EGR2 25348397 N/A physical interaction ComPPI
SOX10 EGR2 14525934 16582099 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED31 EGR2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EGR2 NAB2 25348397 N/A physical interaction ComPPI
EGR2 SRA1 25348397 N/A physical interaction ComPPI
EGR2 JPT2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGR2 BPGM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGR2 NDUFS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGR2 RBM15B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGR2 RIMKLB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGR2 RPL7L1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct

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