Gene Information gene info

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GENE：FLNC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLNC
FullNmae filamin C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3756
EnsembleID ENSG00000128591
Uniprot Q14315

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLNC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FLNC GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0008092,GO:0030018,GO:0030506,GO:0042383,GO:0043034,GO:0045171,GO:0045214,GO:0051015

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FLNC hsa:2318 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FLNC hsa:2318 path:hsa04510 Focal adhesion - Homo sapiens (human)
FLNC hsa:2318 path:hsa05132 Salmonella infection - Homo sapiens (human)
FLNC hsa:2318 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLCG1 FLNC 17474147 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
AR FLNC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 FLNC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FLNC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF FLNC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FLNC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FLNC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FLNC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FLNC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031602A FLNC 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
AKT2 FLNC 22135298 phosphorylation N/A PhosphoSite
AKT1 FLNC 22135298 phosphorylation N/A PhosphoSite
USP25 FLNC 25361965 interaction type N/A PTMCode2
FLNC USP25 25361965 interaction type N/A PTMCode2
MYOZ2 FLNC 25361965 interaction type N/A PTMCode2
FLNC MYOZ2 25361965 interaction type N/A PTMCode2
FLNC MYOZ1 25361965 interaction type N/A PTMCode2
MYOZ1 FLNC 25361965 interaction type N/A PTMCode2
FLNC KY 25361965 interaction type N/A PTMCode2
KY FLNC 25361965 interaction type N/A PTMCode2
INPPL1 FLNC 25361965 interaction type N/A PTMCode2
FLNC INPPL1 25361965 interaction type N/A PTMCode2
MYOZ3 FLNC 25361965 interaction type N/A PTMCode2
FLNC MYOZ3 25361965 interaction type N/A PTMCode2
MAP2K4 FLNC 25361965 interaction type N/A PTMCode2
FLNC MAP2K4 25361965 interaction type N/A PTMCode2
MYOT FLNC 25361965 interaction type N/A PTMCode2
FLNC MYOT 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SF3A3 FLNC 25348397 N/A physical interaction ComPPI
UBE2I FLNC 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CDC73 FLNC 25348397 N/A physical interaction ComPPI
SAP30BP FLNC 25348397 N/A physical interaction ComPPI
SH3GLB1 FLNC 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NPM1 FLNC 25348397 N/A physical interaction ComPPI
MCM5 FLNC 25348397 N/A physical interaction ComPPI
RASSF5 FLNC 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM2 FLNC 25348397 N/A physical interaction ComPPI
MAP1LC3B FLNC 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CRK FLNC 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
KCTD13 FLNC 25348397 N/A physical interaction ComPPI
MYOZ2 FLNC 11842093 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMURF2 FLNC 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIK3R1 FLNC 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PRKCA FLNC 12704190 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NCK1 FLNC 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 FLNC 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
JUN FLNC 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
ADRA1D FLNC 14525934 15525470 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
FLNC ADRA1B 14525934 15525470 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
FLNC ADRA1A 14525934 15525470 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
FLNC CAPN3 14506720 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLNC FURIN 14525934 25348397 9412467 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FLNC INPPL1 11739414 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
FLNC MAP2K4 14525934 25348397 9006895 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
FLNC SGCD 10629222 14506720 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
FLNC MYOT 11038172 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
FLNC MYOZ1 10984498 11171996 11842093 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
FLNC PHLDB2 12376540 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
FLNC SGCG 10629222 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
FLNC KCND2 11102480 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
FLNC NPHP1 12006559 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FLNC MYOZ3 11842093 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLNC HIPK3 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
FLNC OTUD1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC OTUD4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC USP25 25348397 N/A physical interaction ComPPI
FLNC CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC WIPI2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC WNK1 25348397 N/A physical interaction ComPPI
FLNC SIRT7 25348397 N/A physical interaction ComPPI
FLNC PRKAB2 25348397 N/A physical interaction ComPPI
FLNC TRIM54 25348397 N/A physical interaction ComPPI
FLNC CUL3 25348397 N/A physical interaction ComPPI
FLNC CDK2 25348397 N/A physical interaction ComPPI
FLNC FBXL22 25348397 N/A physical interaction ComPPI
FLNC DYNLRB1 25348397 N/A physical interaction ComPPI
FLNC EEF1G 25348397 N/A physical interaction ComPPI
FLNC NUP133 25348397 N/A physical interaction ComPPI
FLNC DYNC1H1 25348397 N/A physical interaction ComPPI
FLNC ENO1 23414517 24234451 25348397 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
FLNC DDB1 25348397 N/A physical interaction ComPPI
FLNC SRSF9 25348397 N/A physical interaction ComPPI
FLNC DCTN1 25348397 N/A physical interaction ComPPI
FLNC FN1 25348397 N/A physical interaction ComPPI
FLNC VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
FLNC TP63 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
FLNC IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNC IGSF8 25348397 N/A physical interaction ComPPI
FLNC RPS6KA2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FLNC ANKRD28 25348397 N/A physical interaction ComPPI
FLNC AP3S1 25348397 N/A physical interaction ComPPI
FLNC ARFGEF2 25348397 N/A physical interaction ComPPI
FLNC FLNB 25348397 N/A physical interaction ComPPI
FLNC KCMF1 25348397 N/A physical interaction ComPPI
FLNC NCAPD2 25348397 N/A physical interaction ComPPI
FLNC IKBKB 25348397 N/A physical interaction ComPPI
FLNC NUP88 25348397 N/A physical interaction ComPPI
FLNC PSMD12 25348397 N/A physical interaction ComPPI
FLNC PSMD13 25348397 N/A physical interaction ComPPI
FLNC PSMD3 25348397 N/A physical interaction ComPPI
FLNC TXNL1 25348397 N/A physical interaction ComPPI
FLNC XIRP2 25348397 N/A physical interaction ComPPI
FLNC XIRP1 16631741 23115302 24234451 25348397 27898060 colocalization,physical association two hybrid,far western blotting,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
FLNC SYNPO2 25348397 N/A physical interaction ComPPI
FLNC TRIM63 18157088 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FLNC TRIM55 25348397 N/A physical interaction ComPPI
FLNC RAPGEF2 25348397 N/A physical interaction ComPPI
FLNC OBSL1 25348397 N/A physical interaction ComPPI
FLNC FBXW11 25348397 N/A physical interaction ComPPI
FLNC TNFAIP1 25348397 N/A physical interaction ComPPI
FLNC SNX24 25348397 N/A physical interaction ComPPI
FLNC ERI2 25348397 N/A physical interaction ComPPI
FLNC CARD8 25348397 N/A physical interaction ComPPI
FLNC DVL1 25348397 N/A physical interaction ComPPI
FLNC DVL1P1 25348397 N/A physical interaction ComPPI
FLNC PIP5K1A 25348397 N/A physical interaction ComPPI
FLNC NAT8L 25348397 N/A physical interaction ComPPI
FLNC HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
FLNC FOXF1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FLNC ATOH1 25348397 N/A physical interaction ComPPI
FLNC HSPB7 25348397 N/A physical interaction ComPPI
FLNC RAB8B 25348397 N/A physical interaction ComPPI
FLNC NUAK2 25348397 N/A physical interaction ComPPI
FLNC GNG3 25348397 N/A physical interaction ComPPI
FLNC NT5C 25348397 N/A physical interaction ComPPI
FLNC PLEKHO1 25348397 N/A physical interaction ComPPI
FLNC FRYL 25348397 N/A physical interaction ComPPI
FLNC PAX4 25348397 N/A physical interaction ComPPI
FLNC C6ORF141 25348397 N/A physical interaction ComPPI
FLNC MFN1 25348397 N/A physical interaction ComPPI
FLNC PSMC4 25348397 N/A physical interaction ComPPI
FLNC SMOX 25348397 N/A physical interaction ComPPI
FLNC RAPGEF5 25348397 N/A physical interaction ComPPI
FLNC CYLD 25348397 N/A physical interaction ComPPI
FLNC BRCA1 25348397 N/A physical interaction ComPPI
FLNC TES 25348397 N/A physical interaction ComPPI
FLNC TNFAIP8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FLNC ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
FLNC FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
FLNC PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
FLNC ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
FLNC MLH1 20706999 24234451 25348397 physical association two hybrid ComPPI,IntAct
FLNC MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FLNC DYSF 23414517 24234451 25348397 colocalization,physical association two hybrid fragment pooling approach,confocal microscopy,proximity ligation assay ComPPI,IntAct
FLNC MYBPC2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
FLNC REPS1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
FLNC ANK3 21223964 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
FLNC SYNM 24234451 25348397 25447537 physical association two hybrid ComPPI,IntAct
FLNC MYBPC3 21569246 24234451 25348397 physical association two hybrid ComPPI,IntAct
FLNC TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
FLNC TUBA1A 24234451 25348397 27291054 association pull down ComPPI,IntAct
FLNC RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1D FLNC 25348397 N/A physical interaction ComPPI
USP53 FLNC 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTTNBP2NL FLNC 25348397 N/A physical interaction ComPPI
FLNC KY 14525934 15385448 N/A experimental interaction detection,two hybrid HPRD
PPIB FLNC 24234451 30021884 physical association cross-linking study IntAct
FLNC DOCK6 24234451 30021884 physical association cross-linking study IntAct
RPL30 FLNC 24234451 30021884 physical association cross-linking study IntAct
H2AC4 FLNC 24234451 30021884 physical association cross-linking study IntAct
FLNC FLG 24234451 30021884 physical association cross-linking study IntAct
FLNA FLNC 24019900 27898060 N/A N/A OmniPath
PLCG1 FLNC 17474147 27898060 N/A N/A OmniPath
AKT2 FLNC 15461588 27898060 N/A N/A OmniPath

Visualization










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