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GENE：FRAT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FRAT1
FullNmae FRAT regulator of WNT signaling pathway 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3944
EnsembleID ENSG00000165879
Uniprot Q92837

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FRAT1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FRAT1 GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0043231,GO:0046825,GO:0060070,GO:0090263,GO:0090263,GO:0140678,GO:1904886

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FRAT1 hsa:10023 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05224 Breast cancer - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
FRAT1 hsa:10023 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FRAT1 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
FRAT1 GSK3B 23331499 9635432 stimulation N/A SignaLink
DVL3 FRAT1 23331499 9635432 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 FRAT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FRAT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 FRAT1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FRAT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D FRAT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE FRAT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000081E1F FRAT1 25416803 27037061 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000EED18 FRAT1 25416803 28340489 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA FRAT1 22135298 phosphorylation N/A PhosphoSite
GSK3B FRAT1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCA FRAT1 22135298 phosphorylation N/A PhosphoSite
FRAT1 GSK3B 25361965 interaction type N/A PTMCode2
FRAT1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 FRAT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KRAS FRAT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
GPRASP2 FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 FRAT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA3 FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GRN FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLSCR1 FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GSK3B FRAT1 11738041 12095675 14525934 23455922 23602568 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
AXIN1 FRAT1 10481074 24234451 25348397 phosphorylation reaction,association pull down,protein kinase assay ComPPI,IntAct
GSK3A FRAT1 10481074 23602568 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
LTBP4 FRAT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DVL1 FRAT1 10428961 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EIF2B5 FRAT1 10481074 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
FRAT1 DVL1P1 25348397 N/A physical interaction ComPPI
FRAT1 LAMC3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRAT1 KCNK5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRAT1 LMAN2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRAT1 TDRD7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRAT1 RABEP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRAT1 MAP3K1 25348397 N/A physical interaction ComPPI
PRKACA FRAT1 16982607 27898060 inhibition N/A OmniPath
DVL3 FRAT1 12556519 27898060 9635432 stimulant N/A OmniPath
FRAT1 GSK3B 10428961 12095675 16982607 18498136 23455922 23602568 26496610 27898060 9635432 inhibition,stimulant N/A OmniPath

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