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GENE：MED15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MED15
FullNmae mediator complex subunit 15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14248
EnsembleID ENSG00000099917
Uniprot Q96RN5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MED15 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MED15 GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0016020,GO:0016592,GO:0032968,GO:0035019,GO:0051123,GO:0060261,GO:0070847

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MED15 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MED15 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MED15 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MED15 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MED15 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MED15 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE MED15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE MED15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D MED15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 MED15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 MED15 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
FHL3 MED15 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP1 MED15 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
ATXN1 MED15 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
SMAD4 MED15 12167862 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
MED21 MED15 25348397 N/A physical interaction ComPPI
MED8 MED15 25348397 N/A physical interaction ComPPI
SMAD1 MED15 12167862 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW7 MED15 25348397 N/A physical interaction ComPPI
SMAD2 MED15 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD3 MED15 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HIF1A MED15 23746844 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TRIP4 MED15 25348397 N/A physical interaction ComPPI
PLSCR1 MED15 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MED1 MED15 20098423 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED24 MED15 25348397 N/A physical interaction ComPPI
UBB MED15 25348397 N/A in vivo ComPPI
UBC MED15 16904669 24234451 25348397 physical association anti tag coimmunoprecipitation,in vivo ComPPI,IntAct
RPS27A MED15 25348397 N/A in vivo ComPPI
UBA52 MED15 25348397 N/A in vivo ComPPI
UBE2N MED15 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
NR1I3 MED15 25348397 N/A physical interaction ComPPI
NCOA6 MED15 25348397 N/A physical interaction ComPPI
SREBF1 MED15 25348397 N/A anti tag coimmunoprecipitation,classical fluorescence spectroscopy,pull down,pull down,physical interaction,physical interaction ComPPI
SREBF2 MED15 16799563 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
TP73 MED15 25348397 N/A physical interaction ComPPI
EWSR1 MED15 25348397 N/A physical interaction ComPPI
RELA MED15 25348397 N/A physical interaction ComPPI
CTDP1 MED15 25348397 N/A physical interaction ComPPI
CHEK1 MED15 25348397 N/A physical interaction ComPPI
MED9 MED15 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HTT MED15 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
MED23 MED15 25348397 N/A physical interaction ComPPI
TRRAP MED15 18418385 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED28 MED15 25348397 N/A physical interaction ComPPI
IGBP1 MED15 25348397 N/A physical interaction ComPPI
MED14 MED15 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED12 MED15 25348397 N/A physical interaction ComPPI
CDK8 MED15 18418385 20098423 23602568 24234451 25348397 29568061 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,ion exchange chromatography,biochemical,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
MED13 MED15 20622008 25348397 27898060 N/A physical interaction ComPPI,OmniPath
QKI MED15 25348397 N/A physical interaction ComPPI
UBAP2L MED15 25348397 N/A physical interaction ComPPI
MED15 MLLT6 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MED15 ATP5F1C 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MED15 TRIM11 14525934 16904669 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
MED15 MED10 15175163 24234451 24882805 25348397 association,physical association anti tag coimmunoprecipitation,electron microscopy,physical interaction,ion exchange chromatography ComPPI,IntAct
MED15 MED19 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED15 ZC3H13 25348397 N/A physical interaction ComPPI
MED15 EPAS1 25348397 N/A physical interaction ComPPI
MED15 CDK19 15175163 23602568 24234451 25348397 association,physical association physical interaction,ion exchange chromatography,tandem affinity purification ComPPI,IntAct
MED15 CCNC 25348397 N/A physical interaction ComPPI
MED15 TCL1B 25348397 N/A physical interaction ComPPI
MED15 MED20 25348397 N/A physical interaction ComPPI
MED15 MED4 25348397 N/A physical interaction ComPPI
MED15 MYO1C 25348397 N/A physical interaction ComPPI
MED15 POLR2F 25348397 N/A physical interaction ComPPI
MED15 POLR2G 25348397 N/A physical interaction ComPPI
MED15 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
MED18 MED15 25348397 N/A physical interaction ComPPI
AKT1 MED15 15575970 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MED15 MAD 15575970 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B9F6C MED15 27087310 direct interaction,inhibition N/A NPInter

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