GENE：PRDM16
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PRDM16 |
| FullNmae | PR/SET domain 16 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14000 |
| EnsembleID | ENSG00000142611 |
| Uniprot | Q9HAZ2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PRDM16 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PRDM16 | GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0001228,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0006357,GO:0016235,GO:0017053,GO:0030512,GO:0032259,GO:0043457,GO:0043565,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0046872,GO:0046974,GO:0050873,GO:0070828,GO:0120162,GO:0140297,GO:0140938,GO:0140947,GO:0140948 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PRDM16 | hsa:63976 | path:hsa00310 | Lysine degradation - Homo sapiens (human) |
| PRDM16 | hsa:63976 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PRDM16 | hsa:63976 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD2 | PRDM16 | 20661427 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMAD3 | PRDM16 | 19049980 20661427 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SKI | PRDM16 | 20661427 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PRDM16 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | PRDM16 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| HIF1A | PRDM16 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| TFAP2C | PRDM16 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PRDM16 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000032BD73 | PRDM16 | 23395168 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS000032BD73 | PRDM16 | 23395168 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000016FF9C | PRDM16 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00003D5391 | PRDM16 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000134ADC | PRDM16 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000170CF4 | PRDM16 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TFAP4 | PRDM16 | 25348397 | N/A | physical interaction | ComPPI |
| SMAD2 | PRDM16 | 25348397 | N/A | physical interaction | ComPPI |
| SMAD3 | PRDM16 | 25348397 | N/A | physical interaction | ComPPI |
| SKI | PRDM16 | 25348397 | N/A | physical interaction | ComPPI |
| SPDEF | PRDM16 | 25348397 | N/A | physical interaction | ComPPI |
| PATJ | PRDM16 | 25348397 | N/A | in vitro | ComPPI |
| H3-4 | PRDM16 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRDM16 | PPARG | 18719582 27898060 | stimulant | N/A | OmniPath |
| PRDM16 | SKI | 19049980 20661427 27898060 | stimulant | N/A | OmniPath |