Gene Information gene info

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GENE：TRAF5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRAF5
FullNmae TNF receptor associated factor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12035
EnsembleID ENSG00000082512
Uniprot O00463

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRAF5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRAF5 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TRAF5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TRAF5 GO:0005164,GO:0005515,GO:0005813,GO:0005829,GO:0006915,GO:0007165,GO:0008270,GO:0008284,GO:0009898,GO:0023019,GO:0031625,GO:0031625,GO:0031996,GO:0031996,GO:0033209,GO:0035631,GO:0042802,GO:0042981,GO:0043122,GO:0043123,GO:0048255,GO:0051091,GO:0051092,GO:0051092,GO:0070534,GO:0097400,GO:0098802

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRAF5 hsa:7188 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa04217 Necroptosis - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05131 Shigellosis - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
TRAF5 hsa:7188 path:hsa05222 Small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K7 TRAF5 17384642 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK4 TRAF5 12446564 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF4 TRAF5 15941918 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF9 TRAF5 15941918 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF8 TRAF5 11971184 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 TRAF5 15383523 23180781 9718306 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
TRAF3 TRAF5 15383523 20161788 23180781 9718306 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer InnateDB
CD40 TRAF5 17332487 20676093 23180781 9718306 physical association anti tag coimmunoprecipitation,pull down InnateDB
TNFRSF11A TRAF5 23180781 9685412 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 TRAF5 23180781 9718306 physical association anti tag coimmunoprecipitation InnateDB
LTBR TRAF5 14517219 23180781 physical association pull down InnateDB
MAP3K11 TRAF5 19918265 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS TRAF5 20161788 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TRAF5 TNFRSF13B 20676093 23180781 physical association pull down InnateDB
TNFRSF17 TRAF5 20676093 23180781 physical association pull down InnateDB
CAMLG TRAF5 20676093 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 COG7 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 TRAF3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 COG5 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 TRAF2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 IL6ST 23180781 24681564 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TRAF5 TNFRSF13B 20005715 interaction type N/A PSP
TRAF5 RIPK2 20005715 interaction type N/A PSP
TRAF5 NGFR 20005715 interaction type N/A PSP
TRAF5 LTBR 20005715 interaction type N/A PSP
TRAF5 RIPK1 20005715 interaction type N/A PSP
TRAF5 MAP3K5 10523862 20005715 21071413 interaction type N/A PSP,SignaLink
TRAF5 TNFRSF19 20005715 interaction type N/A PSP
TRAF5 TNFRSF11A 20005715 interaction type N/A PSP
TRAF5 RIPK1 11479302 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 TRAF5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TRAF5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TRAF5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TRAF5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TRAF5 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TRAF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D4175 TRAF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 TRAF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 TRAF5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 TRAF5 25416803 26872428 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
RIPK2 TRAF5 25361965 interaction type N/A PTMCode2
TRAF5 RIPK2 25361965 interaction type N/A PTMCode2
TRAF5 TNFRSF12A 25361965 interaction type N/A PTMCode2
TNFRSF12A TRAF5 25361965 interaction type N/A PTMCode2
TRAF5 USP7 25361965 interaction type N/A PTMCode2
USP7 TRAF5 25361965 interaction type N/A PTMCode2
TRAF5 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 TRAF5 25361965 interaction type N/A PTMCode2
TRAF5 CD40 25361965 interaction type N/A PTMCode2
CD40 TRAF5 25361965 interaction type N/A PTMCode2
RIPK1 TRAF5 25361965 interaction type N/A PTMCode2
TRAF5 RIPK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI TRAF5 21516116 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
LMO4 TRAF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GOLGA2 TRAF5 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
PIAS2 TRAF5 25348397 N/A two hybrid ComPPI
THAP7 TRAF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LZTS2 TRAF5 25348397 N/A physical interaction ComPPI
TRAF6 TRAF5 21516116 22493164 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
CCDC184 TRAF5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PICK1 TRAF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF111 TRAF5 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SUMO1 TRAF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
USP7 TRAF5 11279055 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBC TRAF5 25348397 N/A physical interaction ComPPI
EIF2AK2 TRAF5 25348397 N/A physical interaction ComPPI
PSMA1 TRAF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP3K5 TRAF5 10523862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF3 TRAF5 14525934 24234451 25241761 25348397 9718306 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,proximity ligation assay,two hybrid prey pooling approach ComPPI,HPRD,IntAct
GORASP2 TRAF5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SDCBP TRAF5 24234451 25348397 25416956 27107012 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TNFRSF17 TRAF5 20676093 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TRAF2 TRAF5 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD23A TRAF5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SRSF1 TRAF5 21822258 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HOMER1 TRAF5 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDM2 TRAF5 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD27 TRAF5 14525934 25348397 9582383 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF5 CD40 14525934 20676093 24234451 25348397 8790348 9990007 association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
TRAF5 TNFRSF4 14525934 25348397 9488716 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF5 LTBR 14517219 14525934 25348397 27898060 8663299 9162022 9511754 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TRAF5 TNFRSF14 14525934 24234451 25348397 9153189 9162022 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
TRAF5 RIPK1 11479302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF5 RIPK2 14525934 25348397 9642260 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF5 TNFRSF11A 10025951 10075662 14525934 24234451 25348397 9774460 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TRAF5 TNFRSF13B 10880535 14525934 20676093 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TRAF5 TRIM37 11279055 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TRAF5 TDP2 10764746 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF5 TNFRSF19 10809768 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
TRAF5 TRAF3IP2 21822258 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
TRAF5 TNFRSF12A 12529173 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
TRAF5 BEX3 10514511 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TRAF5 TNFRSF8 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
TRAF5 NGFR 25348397 N/A physical interaction ComPPI
TRAF5 MAVS 25348397 N/A physical interaction ComPPI
TRAF5 COG5 25348397 N/A physical interaction ComPPI
TRAF5 TICAM1 25348397 N/A physical interaction ComPPI
TRAF5 MAP3K7 25348397 N/A physical interaction ComPPI
TRAF5 TNFRSF9 25348397 N/A physical interaction ComPPI
TRAF5 NFATC2IP 25348397 N/A physical interaction ComPPI
TRAF5 ZMYND11 20138174 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF5 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF5 UBE2O 25348397 N/A physical interaction ComPPI
TRAF5 TRIM27 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF5 TRIM8 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF5 COMMD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF5 DGKH 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF5 ELAVL1 25348397 N/A physical interaction ComPPI
TRAF5 SEC13 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF5 ENOX2 25348397 N/A physical interaction ComPPI
TRAF5 ZFAND6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF5 THAP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRAF5 RORC 25348397 N/A physical interaction ComPPI
TRAF5 HSD17B10 25348397 N/A physical interaction ComPPI
TRAF5 CCDC40 25348397 N/A physical interaction ComPPI
TRAF5 FBXO28 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 TBK1 25348397 N/A physical interaction ComPPI
TRAF5 USP25 23042150 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRAF5 SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 FAM9A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 YPEL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 CIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 GAS8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 CDC37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF5 ZNF655 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAIP TRAF5 25348397 N/A physical interaction ComPPI
MAP3K14 TRAF5 14525934 25348397 9275204 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CAMLG TRAF5 20676093 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SERPINB9 TRAF5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAPNS1 TRAF5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
COG7 TRAF5 25348397 N/A physical interaction ComPPI
TRAF5 TRAF5 14525934 22493164 24234451 25416956 9153189 9162022 physical association experimental interaction detection,two hybrid array,two hybrid prey pooling approach,two hybrid HPRD,IntAct
TANK TRAF5 24234451 30561431 association virotrap IntAct
MAP3K7 TRAF5 17384642 27898060 N/A N/A OmniPath
TRAF5 TRAF2 21903422 27898060 9718306 N/A N/A OmniPath
TRAF5 IL6ST 24681564 27898060 N/A N/A OmniPath
TRAF6 TRAF5 21516116 22493164 25416956 27898060 9718306 N/A N/A OmniPath
MAVS TRAF5 20161788 27898060 N/A N/A OmniPath
TRADD TRAF5 19632174 27898060 stimulant N/A OmniPath
CD40 TRAF5 11562359 12220533 17332487 20614026 20676093 21041727 27898060 8790348 9511754 9718306 9990007 N/A N/A OmniPath
TRAF3 TRAF5 15383523 20161788 21903422 25241761 27898060 9718306 N/A N/A OmniPath
TNFRSF4 TRAF5 15941918 27898060 9488716 N/A N/A OmniPath
TRAF5 MAP3K11 19918265 27898060 N/A N/A OmniPath

Visualization










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