GENE：WNT6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT6 |
| FullNmae | Wnt family member 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12785 |
| EnsembleID | ENSG00000115596 |
| Uniprot | Q9Y6F9 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT6 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT6 | GO:0001658,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0009798,GO:0009986,GO:0010628,GO:0030182,GO:0030182,GO:0030666,GO:0031012,GO:0042475,GO:0045165,GO:0045893,GO:0060070,GO:0060684,GO:0061303,GO:0070062,GO:0070172,GO:0071300,GO:0072079 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT6 | hsa:7475 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT6 | hsa:7475 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | WNT6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PORCN | WNT6 | 10866835 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| WNT6 | RHOU | 25348397 | N/A | physical interaction | ComPPI |
| WNT6 | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT6 | FZD3 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT6 | FZD1 | 12857724 27898060 8717036 | stimulant | N/A | OmniPath |