GENE：COL4A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COL4A1 |
| FullNmae | collagen type IV alpha 1 chain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2202 |
| EnsembleID | ENSG00000187498 |
| Uniprot | P02462 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COL4A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| COL4A1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COL4A1 | GO:0001569,GO:0005201,GO:0005515,GO:0005576,GO:0005576,GO:0005587,GO:0005604,GO:0005604,GO:0005615,GO:0005788,GO:0007420,GO:0007528,GO:0030020,GO:0030020,GO:0030020,GO:0030020,GO:0030198,GO:0030855,GO:0038063,GO:0048407,GO:0048514,GO:0061304,GO:0061333,GO:0062023,GO:0062023,GO:0071230,GO:0071711 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| COL4A1 | hsa:1282 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| COL4A1 | hsa:1282 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | COL4A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | COL4A1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | COL4A1 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TP73 | COL4A1 | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | COL4A1 | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | COL4A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LMX1B | COL4A1 | 12602071 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | COL4A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | COL4A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000076995 | COL4A1 | 20067797 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | COL4A1 | 18390668 \N | rna interference,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | COL4A1 | 18390668 18927107 20371350 22745231 23446348 23592263 25416803 27666438 | mrna cleavage,inhibition | experimental interaction detection,nucleotide sequence identification,clip,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
| URS0000076995 | COL4A1 | 20067797 20371350 22745231 23446348 23592263 25416803 27666438 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS000009262D | COL4A1 | 22573493 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004E008F | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000AA464 | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001F0C23 | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001A405B | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000157026 | COL4A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000045147B | COL4A1 | 20371350 22745231 23446348 23592263 25416803 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS00004F859B | COL4A1 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | COL4A1 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000572E11 | COL4A1 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028D811 | COL4A1 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005A8ED | COL4A1 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024B619 | COL4A1 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EC3B | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004505E4 | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000017EA6A | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023133F | COL4A1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000821E0 | COL4A1 | 25416803 27502506 | mrna cleavage,inhibition | array technology,nucleotide sequence identification,western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DCN | COL4A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A1 | DCN | 25361965 | interaction type | N/A | PTMCode2 |
| THBS1 | COL4A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A1 | THBS1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A2 | COL4A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A1 | COL4A2 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP9 | COL4A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL4A1 | MMP9 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD1 | COL4A1 | 14732718 25348397 27898060 | N/A | two hybrid,in vivo | ComPPI,OmniPath |
| OSM | COL4A1 | 25348397 | N/A | in vitro | ComPPI |
| THBS1 | COL4A1 | 25348397 | N/A | physical interaction | ComPPI |
| PDGFB | COL4A1 | 25348397 | N/A | physical interaction | ComPPI |
| PDGFA | COL4A1 | 25348397 | N/A | physical interaction | ComPPI |
| KIFAP3 | COL4A1 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A2 | COL4A1 | 12011424 24234451 25348397 | covalent binding | molecular sieving,x-ray crystallography,physical interaction,in vitro | ComPPI,IntAct |
| SERPINE2 | COL4A1 | 25348397 | N/A | in vivo | ComPPI |
| ACHE | COL4A1 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| COL4A1 | BMP3 | 25348397 | N/A | in vitro | ComPPI |
| COL4A1 | NID1 | 2506015 25348397 27898060 | N/A | physical interaction,in vitro | ComPPI,OmniPath |
| COL4A1 | COL7A1 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| COL4A1 | MMP9 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| COL4A1 | CD93 | 25348397 | N/A | in vitro | ComPPI |
| COL4A1 | MATN2 | 25348397 | N/A | in vivo | ComPPI |
| COL4A1 | HABP2 | 25348397 | N/A | in vivo | ComPPI |
| COL4A1 | SAA2 | 25348397 | N/A | in vitro | ComPPI |
| COL4A1 | SAA4 | 25348397 | N/A | in vitro | ComPPI |
| COL4A1 | APCS | 25348397 27898060 8662978 | N/A | in vitro | ComPPI,OmniPath |
| COL4A1 | DISC1 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | NID2 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | MAG | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | VHL | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | PLOD1 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | MMP2 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | TINAG | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | COL16A1 | 25348397 | N/A | fluorescence microscopy | ComPPI |
| COL4A1 | COCH | 19013156 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| COL4A1 | KLK6 | 12878203 24234451 25348397 | protein cleavage | protease assay | ComPPI,IntAct |
| TGFBI | COL4A1 | 25348397 | N/A | in vitro | ComPPI |
| COLGALT2 | COL4A1 | 25348397 | N/A | physical interaction | ComPPI |
| SGG | COL4A1 | 25348397 | N/A | pull down | ComPPI |
| COL4A1 | TAK1 | 25348397 | N/A | physical interaction | ComPPI |
| COL4A1 | COL4A1 | 12011424 24234451 | covalent binding | x-ray crystallography | IntAct |
| COL4A1 | ITGAV | 14610079 27898060 | stimulant | N/A | OmniPath |