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GENE：IL4R

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL4R
FullNmae interleukin 4 receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6015
EnsembleID ENSG00000077238
Uniprot P24394

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL4R pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL4R lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
IL4R lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IL4R immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL4R GO:0002532,GO:0002639,GO:0004896,GO:0004913,GO:0005515,GO:0005576,GO:0005654,GO:0005886,GO:0005886,GO:0006955,GO:0007165,GO:0009897,GO:0016064,GO:0019221,GO:0032722,GO:0034451,GO:0035771,GO:0042832,GO:0043032,GO:0043235,GO:0043306,GO:0045063,GO:0045064,GO:0045626,GO:0045630,GO:0120162,GO:1901741

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL4R hsa:3566 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL4R hsa:3566 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL4R hsa:3566 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL4R hsa:3566 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL4R hsa:3566 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL4R hsa:3566 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL4R hsa:3566 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL4R hsa:3566 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL4R IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18243101 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 8910586 9535722 9834059 interaction type,physical association protein cross-linking with a bifunctional reagent,x-ray crystallography ACSN,InnateDB
IL2RG IL4R 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 8266078 9834059 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL4 IL4R 10219247 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 21889455 23124025 23180781 23331499 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type,stimulation,physical association x-ray crystallography ACSN,InnateDB,SignaLink
JAK1 IL4R 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
JAK2 IL4R 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
IL13 IL4R 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
TYK2 IL4R 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
STAT3 IL4R 10347215 10485906 11160275 11371360 11867689 11870632 11875494 12193690 12223527 12401408 12496409 12818165 12907458 14607900 14610620 14670306 15218058 15356132 15465827 15573129 16243976 16413922 16418395 17404308 17485448 18250477 1825141 18776941 19380816 19833085 20093776 20184663 20237412 20406969 20435894 20510870 20580461 20581311 20856220 21372296 21469115 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24030977 24091328 24857661 26192618 27216177 28186502 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
CSF2 IL4R 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845 26192618 interaction type N/A ACSN
IL4R IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4R STAT1 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
IL4R STAT6 10485906 10582086 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 15661890 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21268015 21469115 21840487 23124025 23180781 23331499 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink
IL4R IL18 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4R JAK3 12207328 23180781 23331499 7538655 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
IL4R CD40 12207328 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4R JAK2 12223527 23180781 8609418 physical association anti tag coimmunoprecipitation InnateDB
IL4R IL4 2278997 2307934 23180781 8266078 8639787 physical association anti tag coimmunoprecipitation,protein cross-linking with a bifunctional reagent,saturation binding InnateDB
IL4R IL2RG 23180781 23331499 8266078 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
PTPN6 IL4R 23180781 9065461 physical association anti tag coimmunoprecipitation InnateDB
IL4R IL13 18243101 23180781 8910586 physical association protein cross-linking with a bifunctional reagent,x-ray crystallography InnateDB
IL4R JAK1 12133952 12223527 23180781 23331499 7929391 stimulation,physical association anti tag coimmunoprecipitation,pull down InnateDB,SignaLink
IL4R STAT5B 18820682 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4R STAT5A 18820682 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBX21 IL4R 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL4R 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
IL13RA1 IL4R 23331499 8910586 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IL4R 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TFAP2C IL4R 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IL4R 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 IL4R 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL4R 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001597DC IL4R 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D6C3F IL4R 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 IL4R 22291592 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL4R IL4 25361965 interaction type N/A PTMCode2
IL4 IL4R 25361965 interaction type N/A PTMCode2
IL4R IL2RG 25361965 interaction type N/A PTMCode2
IL2RG IL4R 25361965 interaction type N/A PTMCode2
IL4R DOK2 25361965 interaction type N/A PTMCode2
DOK2 IL4R 25361965 interaction type N/A PTMCode2
IL4R STAT6 25361965 interaction type N/A PTMCode2
STAT6 IL4R 25361965 interaction type N/A PTMCode2
IL4R IRS1 25361965 interaction type N/A PTMCode2
IRS1 IL4R 25361965 interaction type N/A PTMCode2
IL4R SOCS5 25361965 interaction type N/A PTMCode2
SOCS5 IL4R 25361965 interaction type N/A PTMCode2
IL4R FES 25361965 interaction type N/A PTMCode2
FES IL4R 25361965 interaction type N/A PTMCode2
IL4R JAK1 25361965 interaction type N/A PTMCode2
JAK1 IL4R 25361965 interaction type N/A PTMCode2
IL4R IL13RA1 25361965 interaction type N/A PTMCode2
IL13RA1 IL4R 25361965 interaction type N/A PTMCode2
IL4R CD40 25361965 interaction type N/A PTMCode2
CD40 IL4R 25361965 interaction type N/A PTMCode2
IL4R IRS2 25361965 interaction type N/A PTMCode2
IRS2 IL4R 25361965 interaction type N/A PTMCode2
IL4R JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL4R 25361965 interaction type N/A PTMCode2
IL4R PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 IL4R 25361965 interaction type N/A PTMCode2
IL4R JAK3 25361965 interaction type N/A PTMCode2
JAK3 IL4R 25361965 interaction type N/A PTMCode2
IL4R SHC1 25361965 interaction type N/A PTMCode2
SHC1 IL4R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 IL4R 25348397 N/A physical interaction ComPPI
RHOBTB3 IL4R 25348397 N/A physical interaction ComPPI
TYK2 IL4R 25348397 N/A physical interaction ComPPI
PTPN6 IL4R 11714803 14525934 24234451 25348397 9392697 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RACK1 IL4R 12960323 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ERBB2 IL4R 25348397 N/A physical interaction ComPPI
PTPN11 IL4R 11714803 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB10 IL4R 25348397 N/A physical interaction ComPPI
INPP5D IL4R 11714803 14525934 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SHC1 IL4R 10652211 11714803 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FES IL4R 14525934 25348397 7518439 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS2 IL4R 14525934 25348397 8954948 N/A experimental interaction detection,in vitro ComPPI,HPRD
HGS IL4R 25348397 N/A physical interaction ComPPI
JAK1 IL4R 12133952 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MYC IL4R 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
IL13RA1 IL4R 14525934 18243101 24234451 25348397 8910586 N/A experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCZ IL4R 14525934 15526032 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NCF1 IL4R 10369419 25348397 27898060 N/A physical interaction,in vivo ComPPI,OmniPath
NEDD4L IL4R 25348397 N/A physical interaction ComPPI
JAK3 IL4R 14525934 25348397 7538655 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 IL4R 14525934 25348397 8599766 N/A experimental interaction detection,in vivo ComPPI,HPRD
JAK2 IL4R 14525934 25348397 8609418 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STAT6 IL4R 14525934 15661890 24234451 25348397 8816495 9392697 9651359 association experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
IL2RG IL4R 14525934 18243101 24234451 25348397 8266076 8266078 association anti bait coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
ACVR2B IL4R 25348397 N/A physical interaction ComPPI
CD40 IL4R 12207328 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DOK2 IL4R 10856136 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR1A IL4R 25348397 N/A physical interaction ComPPI
STX5 IL4R 25348397 N/A physical interaction ComPPI
PKMYT1 IL4R 25348397 N/A physical interaction ComPPI
TNFRSF10A IL4R 25348397 N/A physical interaction ComPPI
NET1 IL4R 25348397 N/A physical interaction ComPPI
ARL5B IL4R 25348397 N/A physical interaction ComPPI
KAT5 IL4R 25348397 N/A physical interaction ComPPI
ARIH2 IL4R 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UTP6 IL4R 25348397 N/A physical interaction ComPPI
IL4R SOCS5 12242343 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IL4R IL13 11709756 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
IL4R IL4 10219247 11786020 14525934 18243101 23597562 24234451 25348397 8266078 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cross-linking study,experimental interaction detection,isothermal titration calorimetry,scintillation proximity assay,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IL4R NCF1B 25348397 N/A physical interaction ComPPI
IL4R RHBDF2 25348397 N/A physical interaction ComPPI
IL4R ANKLE2 25348397 N/A physical interaction ComPPI
IL4R PRR11 25348397 N/A physical interaction ComPPI
IL4R KCNT2 25348397 N/A physical interaction ComPPI
IL4R DHRS3 25348397 N/A physical interaction ComPPI
IL4R PLEKHH3 25348397 N/A physical interaction ComPPI
IL4R ZDHHC9 25348397 N/A physical interaction ComPPI
IL4R DCAKD 25348397 N/A physical interaction ComPPI
IL4R RELT 25348397 N/A physical interaction ComPPI
IL4R PIBF1 24234451 25218441 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
IL4R IL4R 21058338 24234451 N/A fluorescence correlation spectroscopy IntAct
IL4R STAT6 15661890 21268015 27898060 8816495 9392697 9651359 9712048 stimulant N/A OmniPath
STAT6 IL4R 15661890 21268015 27898060 8816495 9392697 9651359 9712048 stimulant N/A OmniPath
IL4 IL4R 10219247 11786020 11815609 12704343 17312100 18243101 18852293 21889455 2278997 2307934 23597562 27898060 7721786 7918378 8266078 8639787 9874253 stimulant N/A OmniPath
IL4R JAK3 12207328 17312100 27898060 7538655 stimulant N/A OmniPath
IL4R STAT5A 20824124 27898060 stimulant N/A OmniPath
IL4R IRS1 12704343 27898060 7537849 8599766 9697832 stimulant N/A OmniPath
IL4R PTPN6 11714803 27898060 9065461 9392697 N/A N/A OmniPath
PTPN6 IL4R 11714803 27898060 9065461 9392697 inhibition N/A OmniPath
JAK1 IL4R 12133952 12223527 12242343 27898060 7929391 stimulant N/A OmniPath
IL4R JAK1 12133952 12223527 12242343 12704343 17312100 23124025 27898060 7929391 stimulant N/A OmniPath
IL4R IRS2 12704343 27898060 8954948 stimulant N/A OmniPath
IL4R CD40 12207328 27898060 N/A N/A OmniPath
IL13 IL4R 11709756 12704343 18243101 19880493 27898060 7721786 8910586 stimulant N/A OmniPath
JAK2 IL4R 12223527 27898060 8609418 N/A N/A OmniPath
IL4R JAK2 12223527 18852293 27898060 8609418 stimulant N/A OmniPath
IL4R IL2RG 12704343 27898060 8266076 8266078 stimulant N/A OmniPath
IL2RG IL4R 11815609 27898060 7918378 8266076 8266078 N/A N/A OmniPath
SYK IL4R 10358772 27898060 9545332 9670964 9697832 9712048 N/A N/A OmniPath
IL4R IL13RA1 12704343 18243101 27898060 8910586 stimulant N/A OmniPath
IL13RA1 IL4R 18243101 27898060 8910586 stimulant N/A OmniPath
IL4R IL13RA2 12704343 27898060 N/A N/A OmniPath

Visualization










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