Gene Information gene info

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GENE：CBS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CBS
FullNmae cystathionine beta-synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1550
EnsembleID ENSG00000160200
Uniprot P35520

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CBS immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CBS ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CBS ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CBS GO:0001958,GO:0001974,GO:0004122,GO:0004122,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006535,GO:0006563,GO:0006565,GO:0006801,GO:0010749,GO:0019343,GO:0019344,GO:0019346,GO:0019448,GO:0019825,GO:0019899,GO:0020037,GO:0020037,GO:0020037,GO:0021587,GO:0030170,GO:0031625,GO:0042262,GO:0042802,GO:0042803,GO:0043066,GO:0043418,GO:0046872,GO:0050421,GO:0050667,GO:0051593,GO:0060135,GO:0060351,GO:0070025,GO:0070026,GO:0070814,GO:0070814,GO:0071456,GO:0072341,GO:0097746,GO:1904047

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CBS hsa:875 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
CBS hsa:875 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
CBS hsa:875 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CBS hsa:875 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CBS E2F1 21310950 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT5A CBS 23180781 24497979 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CBS 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 CBS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CBS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC CBS 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CBS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFYA CBS 12427542 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CBS 11415440 14670973 20392694 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CBS 11415440 14670973 20392694 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CBS 11415440 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CBS N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN CBS N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB CBS N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A CBS N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 CBS N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 CBS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000013DD8 CBS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 CBS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 CBS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D CBS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D CBS 20371350 23592263 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000235862 CBS 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC CBS 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000003575B CBS 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 CBS 23446348 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E226A CBS 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F14FE CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003538C1 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017EE98 CBS 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D CBS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C CBS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 CBS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 CBS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B CBS 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002D2333 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021202F CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075CC78 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 CBS 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKG1 CBS 22135298 phosphorylation N/A PhosphoSite
CBS HTT 25361965 interaction type N/A PTMCode2
HTT CBS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2I CBS 17087506 25348397 25416956 27898060 N/A physical interaction ComPPI,OmniPath
DAXX CBS 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBSL CBS 25348397 N/A physical interaction ComPPI
HSPA8 CBS 24234451 25348397 25910212 association anti tag coimmunoprecipitation ComPPI,IntAct
FXR2 CBS 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBASH3A CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KEAP1 CBS 25348397 N/A physical interaction ComPPI
HSP90AB1 CBS 24234451 25348397 25910212 association anti tag coimmunoprecipitation ComPPI,IntAct
VBP1 CBS 25348397 N/A physical interaction ComPPI
ERO1A CBS 25348397 N/A physical interaction ComPPI
NF2 CBS 25348397 N/A physical interaction ComPPI
PIAS1 CBS 25348397 N/A physical interaction ComPPI
PRKAR1A CBS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HGS CBS 25348397 N/A physical interaction ComPPI
UBC CBS 25348397 N/A physical interaction ComPPI
UBE2N CBS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 CBS 25348397 N/A physical interaction ComPPI
PSMA1 CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EEF1A1 CBS 25348397 N/A physical interaction ComPPI
DBNL CBS 25348397 N/A physical interaction ComPPI
PTPRR CBS 25348397 N/A physical interaction ComPPI
PA2G4 CBS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PDLIM5 CBS 25348397 N/A physical interaction ComPPI
PKM CBS 25348397 N/A physical interaction ComPPI
RANBP9 CBS 25348397 N/A physical interaction ComPPI
HID1 CBS 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
QARS1 CBS 25348397 N/A physical interaction ComPPI
CBX4 CBS 25348397 N/A physical interaction ComPPI
TRAP1 CBS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
UBA2 CBS 25348397 N/A physical interaction ComPPI
AP1B1 CBS 25348397 N/A physical interaction ComPPI
CDK2 CBS 25348397 N/A physical interaction ComPPI
EHHADH CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZDHHC17 CBS 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HTT CBS 10434301 14525934 25348397 27898060 9466992 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
GABARAP CBS 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GPN1 CBS 25348397 N/A physical interaction ComPPI
RAD23B CBS 25348397 N/A physical interaction ComPPI
PLIN3 CBS 25348397 N/A physical interaction ComPPI
HSPE1 CBS 25348397 N/A physical interaction ComPPI
SEC31A CBS 25348397 N/A physical interaction ComPPI
NUCB1 CBS 25348397 N/A physical interaction ComPPI
IARS1 CBS 25348397 N/A physical interaction ComPPI
TRIM25 CBS 25348397 N/A physical interaction ComPPI
GOPC CBS 25348397 N/A physical interaction ComPPI
PIAS3 CBS 25348397 N/A physical interaction ComPPI
SRP14 CBS 25348397 N/A physical interaction ComPPI
LRSAM1 CBS 25348397 N/A physical interaction ComPPI
OAT CBS 25348397 N/A physical interaction ComPPI
NMD3 CBS 25348397 N/A physical interaction ComPPI
UGP2 CBS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAG1 CBS 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSF1 CBS 25348397 N/A physical interaction ComPPI
NEK7 CBS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SEC24B CBS 25348397 N/A physical interaction ComPPI
NPLOC4 CBS 25348397 N/A physical interaction ComPPI
RSU1 CBS 25348397 N/A physical interaction ComPPI
CBS VTA1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CBS CERT1 19447967 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CBS GON7 25348397 N/A physical interaction ComPPI
CBS DERA 25348397 N/A physical interaction ComPPI
CBS IPO4 25348397 N/A physical interaction ComPPI
CBS IREB2 25348397 N/A physical interaction ComPPI
CBS UBA5 25348397 N/A physical interaction ComPPI
CBS CARS1 25348397 N/A physical interaction ComPPI
CBS ABAT 25348397 N/A physical interaction ComPPI
CBS ASNS 25348397 N/A physical interaction ComPPI
CBS EEF1A1P5 25348397 N/A physical interaction ComPPI
CBS ENOPH1 25348397 N/A physical interaction ComPPI
CBS RTF2 25348397 N/A physical interaction ComPPI
CBS SKIV2L 25348397 N/A physical interaction ComPPI
CBS CTH 25348397 N/A physical interaction ComPPI
CBS UBE3B 25348397 N/A physical interaction ComPPI
CBS OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBS NTAQ1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GPSM1 CBS 25348397 N/A physical interaction ComPPI
CBS CBS 11173483 11483494 12173932 14525934 16189514 19447967 21900206 24234451 25416956 physical association two hybrid,experimental interaction detection,two hybrid array,two hybrid pooling approach,two hybrid HPRD,IntAct
TPM1 CBS 24234451 30021884 physical association cross-linking study IntAct
EIF3B CBS 24234451 30021884 physical association cross-linking study IntAct
TPT1 CBS 24234451 27607350 association anti bait coimmunoprecipitation IntAct
PRKG1 CBS 26368121 27898060 N/A N/A OmniPath
SP1 CBS 14670973 27898060 stimulant N/A OmniPath

Visualization










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