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GENE：CTBP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTBP2
FullNmae C-terminal binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2495
EnsembleID ENSG00000175029
Uniprot P56545

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTBP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CTBP2 GO:0000122,GO:0001221,GO:0001222,GO:0003682,GO:0003713,GO:0003714,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0006357,GO:0008285,GO:0016081,GO:0016616,GO:0017053,GO:0019079,GO:0019901,GO:0042974,GO:0044877,GO:0045892,GO:0045944,GO:0048386,GO:0048790,GO:0050872,GO:0051287,GO:0098684,GO:0098831,GO:0098882,GO:0098978,GO:0098982,GO:0099523,GO:0140297,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTBP2 hsa:1488 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
CTBP2 hsa:1488 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
CTBP2 hsa:1488 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CTBP2 hsa:1488 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KLF8 CTBP2 17671186 19798104 26192618 association N/A ACSN
ZBP1 CTBP2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCNH CTBP2 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
BCL3 CTBP2 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTBP2 PROX1 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTBP2 SOX13 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTBP2 PPP1R15A 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR CTBP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 CTBP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CTBP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CTBP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CTBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIPK2 CTBP2 23393140 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 CTBP2 21867514 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000324096 CTBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000076B539 CTBP2 20371350 22012620 23313552 23592263 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075E2C3 CTBP2 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000003FD55 CTBP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 CTBP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 CTBP2 25416803 25895816 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HIPK2 CTBP2 22135298 phosphorylation N/A PhosphoSite
PNN CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 PNN 25361965 interaction type N/A PTMCode2
CTBP2 HIC1 25361965 interaction type N/A PTMCode2
HIC1 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 ZEB1 25361965 interaction type N/A PTMCode2
ZEB1 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 ZFPM1 25361965 interaction type N/A PTMCode2
ZFPM1 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 NRIP1 25361965 interaction type N/A PTMCode2
NRIP1 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 SOX6 25361965 interaction type N/A PTMCode2
SOX6 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 ELAC2 25361965 interaction type N/A PTMCode2
ELAC2 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 FHL3 25361965 interaction type N/A PTMCode2
FHL3 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 ZFPM2 25361965 interaction type N/A PTMCode2
ZFPM2 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 EHMT2 25361965 interaction type N/A PTMCode2
EHMT2 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 KLF8 25361965 interaction type N/A PTMCode2
KLF8 CTBP2 25361965 interaction type N/A PTMCode2
ZNF217 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 ZNF217 25361965 interaction type N/A PTMCode2
KLF3 CTBP2 25361965 interaction type N/A PTMCode2
CTBP2 KLF3 25361965 interaction type N/A PTMCode2
CTBP2 CTBP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CCNH CTBP2 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,confocal microscopy ComPPI,IntAct
UBE2I CTBP2 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
FHL3 CTBP2 12556451 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
HOXB5 CTBP2 25348397 N/A physical interaction ComPPI
SGTA CTBP2 25348397 N/A physical interaction ComPPI
STX11 CTBP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS28 CTBP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ACTG1 CTBP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NRIP1 CTBP2 14525934 15060175 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP1 CTBP2 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
FOXB1 CTBP2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ZNF512B CTBP2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSHZ3 CTBP2 25348397 N/A physical interaction ComPPI
DMRTB1 CTBP2 25348397 N/A physical interaction ComPPI
FUNDC1 CTBP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EHMT2 CTBP2 25348397 N/A physical interaction ComPPI
SOX13 CTBP2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
FLI1 CTBP2 25348397 N/A physical interaction ComPPI
PPP1R15A CTBP2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
JUN CTBP2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TGIF1 CTBP2 14525934 16189514 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
EP300 CTBP2 14525934 16356938 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MECOM CTBP2 14525934 25348397 9724649 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTBP1 CTBP2 14525934 21988832 24234451 25348397 26496610 9858600 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CTBP2 KLF8 10756197 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CTBP2 CBX4 14525934 25348397 9858600 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTBP2 PNN 25348397 N/A in vivo ComPPI
CTBP2 ZFPM2 10438528 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTBP2 ELAC2 14525934 25348397 9858600 N/A experimental interaction detection,in vivo ComPPI,HPRD
CTBP2 SOX6 11504872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTBP2 ZFPM1 11940669 14525934 19654328 21988832 24234451 25348397 27898060 9724649 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
CTBP2 KLF3 14525934 25348397 9724649 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTBP2 TEAD3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTBP2 NOL4 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTBP2 AKTIP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTBP2 BAZ2B 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTBP2 ZEB1 12714599 14525934 25348397 9724649 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CTBP2 ZEB2 12714599 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
CTBP2 MDM2 12867035 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTBP2 SVIL 14525934 16880273 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CTBP2 RAI2 16189514 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 ZNF217 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 RCOR1 25348397 N/A physical interaction ComPPI
CTBP2 HDAC2 25348397 N/A physical interaction ComPPI
CTBP2 HIC1 19486893 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CTBP2 EHMT1 25348397 N/A physical interaction ComPPI
CTBP2 WIZ 25348397 N/A physical interaction ComPPI
CTBP2 LCOR 24234451 25348397 25416956 27705803 association,physical association physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 KAT2B 25348397 N/A physical interaction ComPPI
CTBP2 BCL3 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CTBP2 H3-4 25348397 N/A physical interaction ComPPI
CTBP2 ZBP1 25348397 N/A physical interaction ComPPI
CTBP2 CDKN2A 25348397 N/A physical interaction ComPPI
CTBP2 CDKN2A 25348397 N/A physical interaction ComPPI
CTBP2 UBC 25348397 N/A physical interaction ComPPI
CTBP2 ATXN1L 25348397 N/A physical interaction ComPPI
CTBP2 RUNX1 25348397 N/A physical interaction ComPPI
CTBP2 APP 25348397 N/A physical interaction ComPPI
CTBP2 ECT2 25348397 N/A physical interaction ComPPI
CTBP2 STUB1 25348397 N/A physical interaction ComPPI
CTBP2 PROX1 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CTBP2 CASP8AP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTBP2 C15ORF39 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTBP2 RPL7A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 XRCC6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTBP2 DVL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 RBBP8 21988832 24234451 25348397 26807646 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CTBP2 RPL17 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 RPS4X 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 RPS29 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 CCR5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTBP2 DYRK1B 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 TRNT1 25348397 N/A physical interaction ComPPI
CTBP2 SMAD6 25348397 N/A physical interaction ComPPI
CTBP2 SPRTN 25348397 N/A physical interaction ComPPI
CTBP2 IKZF1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 ZBTB18 25348397 N/A physical interaction ComPPI
CTBP2 IKZF2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 PLCB1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 BCAS3 25348397 N/A physical interaction ComPPI
CTBP2 RIMBP3 25348397 N/A physical interaction ComPPI
CTBP2 FOXP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 NOL4L 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 EGFR 25348397 N/A physical interaction ComPPI
CTBP2 VSX1 25348397 N/A physical interaction ComPPI
CTBP2 CTPS1 25348397 N/A physical interaction ComPPI
CTBP2 MED23 25348397 N/A physical interaction ComPPI
CTBP2 MARK3 25348397 N/A physical interaction ComPPI
CTBP2 MVD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 RBM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 ZC3H3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 GPALPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 CWC22 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 RBM26 25348397 N/A physical interaction ComPPI
CTBP2 RAB11FIP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP2 KCNIP3 16787403 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTBP2 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 FOXP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 FOXS1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTBP2 CDC25C 25348397 N/A physical interaction ComPPI
CTBP2 MTMR7 25348397 N/A physical interaction ComPPI
CTBP2 ZBTB42 25348397 N/A physical interaction ComPPI
CTBP2 IGFBP1 25348397 N/A physical interaction ComPPI
CTBP2 MRPS7 25348397 N/A physical interaction ComPPI
CTBP2 MARF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CTBP2 HELZ 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CTBP2 TRIM25 25348397 N/A physical interaction ComPPI
CTBP2 UHRF2 25348397 N/A physical interaction ComPPI
CTBP2 HNRNPL 25348397 N/A physical interaction ComPPI
CTBP2 CFTR 25348397 N/A physical interaction ComPPI
CTBP2 ANG 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
CTBP2 BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
CTBP2 MDC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SOX2 CTBP2 25348397 N/A physical interaction ComPPI
DDX19B CTBP2 25348397 N/A physical interaction ComPPI
EEF1D CTBP2 25348397 N/A two hybrid,in vitro,in vivo ComPPI
PSMF1 CTBP2 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CTPS2 CTBP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ZNF750 CTBP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTBP2 CTBP2 14525934 9858600 N/A experimental interaction detection HPRD
ZBP1 CTBP2 21903422 27898060 N/A N/A OmniPath

Visualization










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