GENE：CXCR5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CXCR5 |
| FullNmae | C-X-C motif chemokine receptor 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1060 |
| EnsembleID | ENSG00000160683 |
| Uniprot | P32302 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CXCR5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CXCR5 | GO:0004930,GO:0005515,GO:0005886,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0016493,GO:0016494,GO:0019722,GO:0019957,GO:0030595,GO:0032467,GO:0042113,GO:0048535,GO:0060326,GO:0070098 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CXCR5 | hsa:643 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CXCR5 | hsa:643 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
| CXCR5 | hsa:643 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCR5 | RXRA | 14993281 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| RARA | CXCR5 | 14993281 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| CXCR5 | POU2F1 | 14993281 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| NFATC3 | CXCR5 | 14993281 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CXCR5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | CXCR5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NFATC3 | CXCR5 | 14993281 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| POU2F1 | CXCR5 | 14993281 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| RARA | CXCR5 | 14993281 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| RXRA | CXCR5 | 14993281 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CXCR5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF4 | CXCR5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CXCR5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000166778 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008AA34 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000118224 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | CXCR5 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAQ | CXCR5 | 15251452 24234451 25348397 | physical association | coimmunoprecipitation | ComPPI,IntAct |
| CCL5 | CXCR5 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| GNA13 | CXCR5 | 23773523 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CCL3 | CXCR5 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| CCL4 | CXCR5 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| CXCL13 | CXCR5 | 14525934 25348397 9463416 9486651 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CXCR4 | CXCR5 | 23773523 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GNA11 | CXCR5 | 25348397 | N/A | physical interaction | ComPPI |
| CCL16 | CXCR5 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| GNAI2 | CXCR5 | 15251452 23773523 24234451 25241761 25348397 | phosphorylation reaction,physical association | anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,proximity ligation assay | ComPPI,IntAct |
| GNAO1 | CXCR5 | 15251452 24234451 25348397 | physical association | coimmunoprecipitation | ComPPI,IntAct |
| GNB3 | CXCR5 | 23773523 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GNG8 | CXCR5 | 23773523 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CXCR5 | CXCR5 | 12447991 14525934 | N/A | experimental interaction detection | HPRD |
| TSC2 | CXCR5 | 15972957 27898060 | N/A | N/A | OmniPath |
| CXCL13 | CXCR5 | 24218476 27898060 9463416 9486651 | stimulant | N/A | OmniPath |