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GENE：DLL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DLL3
FullNmae delta like canonical Notch ligand 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2909
EnsembleID ENSG00000090932
Uniprot Q9NYJ7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DLL3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DLL3 GO:0001501,GO:0001756,GO:0005112,GO:0005112,GO:0005509,GO:0005886,GO:0007219,GO:0007386,GO:0016020,GO:0030154,GO:0045746,GO:0048339,GO:0050768

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DLL3 hsa:10683 path:hsa01522 Endocrine resistance - Homo sapiens (human)
DLL3 hsa:10683 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
DLL3 hsa:10683 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
DLL3 hsa:10683 path:hsa05200 Pathways in cancer - Homo sapiens (human)
DLL3 hsa:10683 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
DLL3 hsa:10683 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DLL3 DLL3 16140393 26467481 bind,up-regulates activity N/A Signor
DLL3 NOTCH1 10958687 23331499 stimulation N/A SignaLink,SignaLink
LFNG DLL3 10934472 23331499 stimulation N/A SignaLink,SignaLink
DLL3 NOTCH2 11823422 23331499 stimulation N/A SignaLink
MFNG DLL3 15574878 23331499 stimulation N/A SignaLink
GALM DLL3 15574878 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
YBX1 DLL3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DLL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LFNG DLL3 10934472 27898060 stimulant N/A OmniPath
DLL3 NOTCH1 16140393 27898060 stimulant N/A OmniPath
MIB1 DLL3 16140393 27898060 stimulant N/A OmniPath
DLL3 NOTCH2 11823422 27898060 stimulant N/A OmniPath

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