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GENE：DTX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DTX1
FullNmae deltex E3 ubiquitin ligase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3060
EnsembleID ENSG00000135144
Uniprot Q86Y01

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DTX1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DTX1 GO:0003713,GO:0005112,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006351,GO:0006366,GO:0007166,GO:0007219,GO:0008270,GO:0008593,GO:0010001,GO:0016567,GO:0016567,GO:0016604,GO:0017124,GO:0030217,GO:0031625,GO:0045581,GO:0045665,GO:0045893,GO:0061630,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DTX1 hsa:1840 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DTX1 UBE2D1 26192618 interaction type N/A ACSN
DTX1 UBE2D2 26192618 interaction type N/A ACSN
DTX1 DTX1 11153911 26467481 ubiquitination reaction,up-regulates activity N/A Signor
DTX1 NOTCH1 11153911 11226752 11564735 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
DTX1 NOTCH1 20005715 interaction type N/A PSP,SignaLink
DTX1 NOTCH2 20005715 interaction type N/A PSP
DTX1 EP300 11564735 20005715 21071413 interaction type N/A PSP,SignaLink
DTX1 NOTCH2 18988627 20005715 9244302 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 DTX1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DTX1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DTX1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DTX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DTX1 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 DTX1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 DTX1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003AA845 DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 DTX1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DTX1 NOTCH1 25361965 interaction type N/A PTMCode2
NOTCH1 DTX1 25361965 interaction type N/A PTMCode2
DTX1 ITCH 25361965 interaction type N/A PTMCode2
ITCH DTX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TAX1BP3 DTX1 25348397 N/A physical interaction ComPPI
UBE2D1 DTX1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CRK DTX1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
UBE2D4 DTX1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH1 DTX1 11226752 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GRB2 DTX1 14525934 25348397 27898060 9590294 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
EP300 DTX1 11564735 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBE2D2 DTX1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAR1A DTX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBC DTX1 17028573 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
UBE2N DTX1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EIF3F DTX1 25348397 N/A physical interaction ComPPI
DTX1 NOTCH2 14525934 25348397 9244302 N/A experimental interaction detection,in vivo ComPPI,HPRD
DTX1 DTX2 11226752 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DTX1 DTX3 11226752 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DTX1 DTX3L 12670957 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DTX1 ITCH 14525934 17028573 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
DTX1 UBE2C 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 UBE2D3 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 UBE2E1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 UBE2U 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 MAP3K1 25348397 N/A physical interaction ComPPI
DTX1 EGR2 25348397 N/A physical interaction ComPPI
DTX1 DEFA5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 G3BP1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTX1 DTX1 12670957 14525934 N/A experimental interaction detection HPRD
ITCH DTX1 17028573 18628966 27898060 inhibition N/A OmniPath
DTX1 EP300 11564735 27898060 stimulant N/A OmniPath
DTX1 NOTCH1 11153911 11226752 11564735 20208568 27898060 stimulant N/A OmniPath
HES1 DTX1 20208568 27898060 inhibition N/A OmniPath
DTX1 ASCL1 11564735 27898060 inhibition N/A OmniPath

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