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GENE：FADS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FADS2
FullNmae fatty acid desaturase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3575
EnsembleID ENSG00000134824
Uniprot O95864

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FADS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADS2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADS2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FADS2 GO:0004768,GO:0005789,GO:0005886,GO:0006629,GO:0006636,GO:0016020,GO:0016213,GO:0016717,GO:0036109,GO:0043651

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FADS2 hsa:9415 path:hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human)
FADS2 hsa:9415 path:hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
FADS2 hsa:9415 path:hsa01100 Metabolic pathways - Homo sapiens (human)
FADS2 hsa:9415 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
FADS2 hsa:9415 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FADS2 CLN3 23180781 23464991 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR FADS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 FADS2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 FADS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FADS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FADS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 FADS2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FADS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FADS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARA FADS2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 FADS2 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000324096 FADS2 18668040 23622248 25416803 mrna cleavage,inhibition experimental interaction detection,clash TarBase
URS0000237AF9 FADS2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 FADS2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000035CC3E FADS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039A052 FADS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 FADS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D FADS2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NTRK1 FADS2 25348397 N/A physical interaction ComPPI
EGFR FADS2 25348397 N/A physical interaction ComPPI
TRIM25 FADS2 25348397 N/A physical interaction ComPPI
ATP1B3 FADS2 25348397 N/A physical interaction ComPPI
CLN3 FADS2 25348397 N/A physical interaction ComPPI
ATXN1L FADS2 25348397 N/A physical interaction ComPPI
TCTN2 FADS2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FADS2 VSIG4 25348397 N/A physical interaction ComPPI
FADS2 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NUDCD1 FADS2 24234451 29021621 association anti tag coimmunoprecipitation IntAct
FADS2 CCDC110 24234451 30021884 physical association cross-linking study IntAct
FADS2 CLGN 24234451 30021884 physical association cross-linking study IntAct
GPBP1L1 FADS2 24234451 30021884 physical association cross-linking study IntAct
FADS2 LELP1 24234451 30021884 physical association cross-linking study IntAct
FADS2 APOB 24234451 30021884 physical association cross-linking study IntAct
FADS2 SPDL1 24234451 30021884 physical association cross-linking study IntAct

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