GENE：FBXO8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FBXO8 |
| FullNmae | F-box protein 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:13587 |
| EnsembleID | ENSG00000164117 |
| Uniprot | Q9NRD0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FBXO8 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FBXO8 | GO:0000151,GO:0005085,GO:0006511,GO:0032012 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FBXO8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | FBXO8 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | FBXO8 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | FBXO8 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | FBXO8 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | FBXO8 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FBXO8 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | FBXO8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | FBXO8 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000195F5B | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048D44E | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | FBXO8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | FBXO8 | 25416803 27916606 | mrna cleavage,inhibition | array technology,western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SKP1 | FBXO8 | 10531037 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MYC | FBXO8 | 25348397 | N/A | physical interaction | ComPPI |
| ARF6 | FBXO8 | 25348397 | N/A | physical interaction | ComPPI |
| CUL1 | FBXO8 | 25348397 | N/A | physical interaction | ComPPI |
| CDK16 | FBXO8 | 22184064 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| ELAVL1 | FBXO8 | 25348397 | N/A | physical interaction | ComPPI |
| MTOR | FBXO8 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO8 | BIN3 | 25348397 | N/A | physical interaction | ComPPI |