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GENE：FES

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FES
FullNmae FES proto-oncogene, tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3657
EnsembleID ENSG00000182511
Uniprot P07332

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FES lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
FES lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FES immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FES GO:0001578,GO:0004713,GO:0004713,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006468,GO:0006935,GO:0007098,GO:0007155,GO:0008017,GO:0008360,GO:0009898,GO:0010976,GO:0015630,GO:0018108,GO:0030155,GO:0031116,GO:0031410,GO:0034987,GO:0035091,GO:0042127,GO:0043304,GO:0043304,GO:0045595,GO:0045639,GO:0045657,GO:0046777,GO:0051450,GO:0060038,GO:0060627,GO:0071305,GO:2000145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FES hsa:2242 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FES SPI1 23180781 8657143 physical association electrophoretic mobility supershift assay InnateDB
ELF1 FES 23180781 8657143 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FES 18971253 7624145 8657143 trascriptional regulation,stimulation inferred by curator TFlink
VDR FES 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FES 8657143 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FES 8657143 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 FES 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
FES FES 22135298 phosphorylation N/A PhosphoSite
FES BCR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
FES NSF 22135298 phosphorylation N/A PhosphoSite
STAT3 FES 25361965 interaction type N/A PTMCode2
FES STAT3 25361965 interaction type N/A PTMCode2
FES JAK1 25361965 interaction type N/A PTMCode2
JAK1 FES 25361965 interaction type N/A PTMCode2
FES IRS2 25361965 interaction type N/A PTMCode2
IRS2 FES 25361965 interaction type N/A PTMCode2
FES JAK3 25361965 interaction type N/A PTMCode2
JAK3 FES 25361965 interaction type N/A PTMCode2
IL4R FES 25361965 interaction type N/A PTMCode2
FES IL4R 25361965 interaction type N/A PTMCode2
DPYSL5 FES 25361965 interaction type N/A PTMCode2
FES DPYSL5 25361965 interaction type N/A PTMCode2
SPI1 FES 25361965 interaction type N/A PTMCode2
FES SPI1 25361965 interaction type N/A PTMCode2
PIK3R1 FES 25361965 interaction type N/A PTMCode2
FES PIK3R1 25361965 interaction type N/A PTMCode2
BCR FES 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PDE4DIP FES 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AB1 FES 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MDFI FES 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
KIT FES 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R1 FES 14525934 25348397 8916957 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 FES 11071635 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
AR FES 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
FES RASA3 14525934 25348397 7691175 N/A experimental interaction detection,in vitro ComPPI,HPRD
FES PLXNA1 12093729 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES HSH2D 11700021 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FES STAT3 14525934 25348397 9714332 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FES JAK2 14525934 25348397 8631962 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES CSF2RB 14525934 25348397 8631962 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES IRS1 10856136 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FES JAK1 11160325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES JAK3 11160325 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES IRS2 10856136 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FES RASA1 14525934 25348397 7691175 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FES IL4R 14525934 25348397 7518439 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES BCR 14525934 25348397 7529874 8955135 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FES PSMD13 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FES HSP90AA1 25348397 N/A physical interaction ComPPI
FES HSP90AA2P 25348397 N/A physical interaction ComPPI
FES HSPA4 25348397 N/A physical interaction ComPPI
FES FKBP4 25348397 N/A physical interaction ComPPI
FES FKBP5 25348397 N/A physical interaction ComPPI
FES PTGES3 25348397 N/A physical interaction ComPPI
FES ZNF775 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FES ZNF746 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FES NEDD4 25348397 N/A physical interaction ComPPI
FES TERF1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
FES POT1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
FES TRIM28 16792528 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FES EGFR 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
FES DSP 24234451 25348397 25852190 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FES APP 25348397 N/A physical interaction ComPPI
FES SMURF1 25348397 N/A physical interaction ComPPI
FES EZR 18046454 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct
FES ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
FES NSF 15322554 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
FES MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 FES 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
DPYSL5 FES 12093729 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPID FES 25348397 N/A physical interaction ComPPI
FES FES 14525934 24234451 7687763 8663427 association experimental interaction detection,pull down HPRD,IntAct
BCAR1 FES 14525934 8999909 N/A experimental interaction detection HPRD
EZR FES 18046454 27898060 stimulant N/A OmniPath
FES BCR 10405761 10706130 12522270 15302586 16497976 27898060 7529874 8955135 9178913 9407116 inhibition,stimulant N/A OmniPath
FES NSF 15322554 27898060 N/A N/A OmniPath
FES ACHE 27898060 7836436 N/A N/A OmniPath
FES AGA 27898060 9362483 N/A N/A OmniPath

Visualization










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