GENE：FGF18
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FGF18 |
| FullNmae | fibroblast growth factor 18 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3674 |
| EnsembleID | ENSG00000156427 |
| Uniprot | O76093 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FGF18 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FGF18 | GO:0001525,GO:0001934,GO:0001957,GO:0001958,GO:0002063,GO:0005105,GO:0005105,GO:0005111,GO:0005111,GO:0005576,GO:0005615,GO:0005730,GO:0005737,GO:0007165,GO:0007267,GO:0008083,GO:0008283,GO:0008284,GO:0008543,GO:0009653,GO:0009887,GO:0010628,GO:0030154,GO:0030324,GO:0030334,GO:0030949,GO:0032332,GO:0043406,GO:0043536,GO:0045766,GO:0048010,GO:0070371,GO:0070374,GO:2000546 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FGF18 | hsa:8817 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| FGF18 | hsa:8817 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | FGF18 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | FGF18 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FGFR2 | FGF18 | 25348397 | N/A | in vitro | ComPPI |
| FGFR3 | FGF18 | 25348397 | N/A | in vitro | ComPPI |
| FGFR1 | FGF18 | 25348397 | N/A | in vitro | ComPPI |
| FGFR4 | FGF18 | 25348397 | N/A | in vitro | ComPPI |
| LYAR | FGF18 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| FGF18 | FGFR2 | 10751172 27898060 8663044 | stimulant | N/A | OmniPath |