GENE：FTO
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FTO |
| FullNmae | FTO alpha-ketoglutarate dependent dioxygenase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:24678 |
| EnsembleID | ENSG00000140718 |
| Uniprot | Q9C0B1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FTO | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FTO | GO:0001659,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006307,GO:0008198,GO:0008198,GO:0010883,GO:0016607,GO:0016740,GO:0035515,GO:0035516,GO:0035516,GO:0035552,GO:0035552,GO:0035553,GO:0035553,GO:0035553,GO:0040014,GO:0042245,GO:0043231,GO:0043734,GO:0043734,GO:0044065,GO:0060612,GO:0061157,GO:0070350,GO:0070989,GO:0080111,GO:0090335,GO:1990931,GO:1990931,GO:1990931,GO:1990984 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FTO | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | FTO | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | FTO | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | FTO | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | FTO | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FTO | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | FTO | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | FTO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | FTO | 23341774 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | FTO | 23341774 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | FTO | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000075C1E1 | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032AE90 | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | FTO | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GPX7 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| LDHB | FTO | 25348397 | N/A | physical interaction | ComPPI |
| LDHA | FTO | 25348397 | N/A | physical interaction | ComPPI |
| GABARAPL2 | FTO | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| NFYA | FTO | 25348397 | N/A | physical interaction | ComPPI |
| SLC9A3R1 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| MPZL1 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| NDRG1 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| BCCIP | FTO | 25348397 | N/A | physical interaction | ComPPI |
| SDC1 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| CTSA | FTO | 25348397 | N/A | physical interaction | ComPPI |
| FGB | FTO | 25348397 | N/A | physical interaction | ComPPI |
| MVD | FTO | 25348397 | N/A | physical interaction | ComPPI |
| EEF2 | FTO | 25348397 | N/A | physical interaction | ComPPI |
| SLX4 | FTO | 19596235 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TKFC | FTO | 25348397 | N/A | physical interaction | ComPPI |
| CEBPA | FTO | 24234451 24877091 | association | chromatin immunoprecipitation assay | IntAct |