GENE：ICOS
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ICOS |
| FullNmae | inducible T cell costimulator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5351 |
| EnsembleID | ENSG00000163600 |
| Uniprot | Q9Y6W8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ICOS | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ICOS | GO:0002517,GO:0005515,GO:0005576,GO:0005886,GO:0006955,GO:0031295,GO:0098609 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ICOS | hsa:29851 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| ICOS | hsa:29851 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| ICOS | hsa:29851 | path:hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| ICOS | hsa:29851 | path:hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ICOSLG | ICOS | 11007762 20116985 26192618 | interaction type | N/A | ACSN |
| ICOS | CD40LG | 10426994 11907067 15536084 16713974 20116985 21708958 26192618 | interaction type | N/A | ACSN |
| TBX21 | ICOS | 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26192618 26885856 | interaction type | N/A | ACSN |
| ICOS | ICOS | 11169414 23180781 | physical association | pull down | InnateDB |
| PIK3R1 | ICOS | 18641334 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ICOS | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ICOS | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ICOS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCP2 | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| WIF1 | ICOS | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIK3R1 | ICOS | 18641334 24234451 25348397 27135603 | association,physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| BAG6 | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TNF | ICOS | 25348397 | N/A | physical interaction | ComPPI |
| KLC1 | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| NAA10 | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MYCBP2 | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TBK1 | ICOS | 24234451 25348397 27135603 | association,physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| GAK | ICOS | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ICOS | ICOSLG | 11956294 16951355 24234451 25348397 | physical association | far western blotting,fluorescence-activated cell sorting,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vitro | ComPPI,IntAct |
| ICOS | ACY1 | 25348397 | N/A | physical interaction | ComPPI |
| ICOS | MELTF | 25348397 | N/A | physical interaction | ComPPI |
| ICOS | GSTZ1 | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ICOS | ERLIN2 | 24234451 25348397 27135603 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ICOS | ICOS | 11169414 14525934 | N/A | experimental interaction detection | HPRD |
| ICOS | ICOSLG | 10657606 11023515 11956294 23954143 27898060 | N/A | N/A | OmniPath |