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GENE：KCNH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KCNH2
FullNmae potassium voltage-gated channel subfamily H member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6251
EnsembleID ENSG00000055118
Uniprot Q12809

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KCNH2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KCNH2 GO:0000976,GO:0003064,GO:0005242,GO:0005242,GO:0005242,GO:0005249,GO:0005251,GO:0005251,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0008076,GO:0008076,GO:0009986,GO:0031625,GO:0042391,GO:0042802,GO:0042803,GO:0045893,GO:0048471,GO:0055075,GO:0055131,GO:0060048,GO:0060306,GO:0060307,GO:0060307,GO:0071466,GO:0071805,GO:0071805,GO:0086005,GO:0086008,GO:0086009,GO:0086010,GO:0086011,GO:0086011,GO:0086013,GO:0086091,GO:0086091,GO:0097110,GO:0097623,GO:0097623,GO:0098915,GO:1901379,GO:1901380,GO:1901381,GO:1902282,GO:1902937,GO:1903765,GO:1990573

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KCNH2 DNAJA1 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
KCNH2 HSPA8 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
HSP90AA1 KCNH2 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
KCNH2 STIP1 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
KCNH2 BAG2 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
FKBP8 KCNH2 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB
KCNH2 CANX 17569659 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YWHAE KCNH2 20005715 interaction type N/A PSP
YWHAH KCNH2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 KCNH2 18971253 20019798 7731694 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 KCNH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 KCNH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KCNH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KCNH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KCNH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 KCNH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ERG KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 KCNH2 7731694 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
LMO2 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
LYL1 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink
SP1 KCNH2 17311278 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 KCNH2 17311278 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 KCNH2 21536859 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032BD73 KCNH2 17344217 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000032BD73 KCNH2 17344217 25355491 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 KCNH2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 KCNH2 25355491 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005FDE70 KCNH2 25416803 25824027 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000009EA8F KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002EF20A KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001799A3 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000364FEF KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000EF0B KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045ED38 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027F5F3 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759B6A KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000024CEE0 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001F373E KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E177F KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005DEC41 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019D79B KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 KCNH2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA KCNH2 22135298 phosphorylation N/A PhosphoSite
PRKCA KCNH2 22135298 phosphorylation N/A PhosphoSite
KCNH2 ALG10 25361965 interaction type N/A PTMCode2
ALG10 KCNH2 25361965 interaction type N/A PTMCode2
KCNH2 KCNE2 25361965 interaction type N/A PTMCode2
KCNE2 KCNH2 25361965 interaction type N/A PTMCode2
KCNH2 KCNE1 25361965 interaction type N/A PTMCode2
KCNE1 KCNH2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC73 KCNH2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HSPA8 KCNH2 25348397 N/A physical interaction ComPPI
MAP1LC3B KCNH2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKACA KCNH2 10837251 11953308 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSP90AA1 KCNH2 12775586 17569659 23963841 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NTRK1 KCNH2 25348397 N/A physical interaction ComPPI
CANX KCNH2 17569659 22242185 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CAV1 KCNH2 18923542 24234451 25348397 colocalization,physical association two hybrid,confocal microscopy ComPPI,IntAct
CALR KCNH2 25348397 N/A physical interaction ComPPI
STIP1 KCNH2 25348397 N/A physical interaction ComPPI
HSPA1A KCNH2 25348397 N/A physical interaction ComPPI
HSPA1B KCNH2 25348397 N/A physical interaction ComPPI
NEDD4L KCNH2 22879586 24688054 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CAV3 KCNH2 25348397 N/A physical interaction ComPPI
CUL1 KCNH2 25348397 N/A physical interaction ComPPI
RAB11A KCNH2 25348397 N/A physical interaction ComPPI
YWHAH KCNH2 11953308 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
YWHAE KCNH2 11953308 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
HSPA4 KCNH2 25348397 N/A physical interaction ComPPI
GABARAP KCNH2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RNF139 KCNH2 25348397 N/A physical interaction ComPPI
RHOH KCNH2 14525934 16169070 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
FKBP8 KCNH2 25348397 N/A physical interaction ComPPI
KCNH2 NDUFS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KCNH2 ALG10 25348397 N/A in vivo ComPPI
KCNH2 ALG10B 14525934 14525949 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KCNH2 KCNE1 14525934 25348397 9230439 N/A experimental interaction detection,physical interaction ComPPI,HPRD
KCNH2 HSP90AA2P 25348397 N/A physical interaction ComPPI
KCNH2 DNAJA1 25348397 N/A physical interaction ComPPI
KCNH2 BAG2 25348397 N/A physical interaction ComPPI
KCNH2 STUB1 25348397 N/A physical interaction ComPPI
KCNH2 PASK 21418524 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
KCNE2 KCNH2 11278781 14525934 N/A experimental interaction detection HPRD
KCNH2 KCNH2 24234451 24931372 8995352 N/A cross-linking study,molecular sieving,nuclear magnetic resonance IntAct
PRKACA KCNH2 10488078 10837251 11953308 18791070 19651622 27898060 stimulant N/A OmniPath
LCK KCNH2 10837251 11953308 27898060 N/A N/A OmniPath
PRKCA KCNH2 10488078 10837251 11953308 22653970 27898060 N/A N/A OmniPath
KCNH2 HSPA8 17569659 27898060 N/A N/A OmniPath
PTPN6 KCNH2 12361947 27898060 inhibition N/A OmniPath
MINK1 KCNH2 27898060 9230439 stimulant N/A OmniPath

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