GENE：KLHL6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KLHL6 |
| FullNmae | kelch like family member 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18653 |
| EnsembleID | ENSG00000172578 |
| Uniprot | Q8WZ60 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KLHL6 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KLHL6 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KLHL6 | GO:0002467,GO:0005515,GO:0009617,GO:0050853 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KLHL6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | KLHL6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | KLHL6 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | KLHL6 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | KLHL6 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | KLHL6 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | KLHL6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BYSL | KLHL6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HSP90AB1 | KLHL6 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| HSP90AA1 | KLHL6 | 25348397 | N/A | physical interaction | ComPPI |
| CRY2 | KLHL6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NUDC | KLHL6 | 24234451 25036637 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| PPP1R1B | KLHL6 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| FH | KLHL6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TMPO | KLHL6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SBDS | KLHL6 | 24234451 25348397 26871637 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |