Gene Information gene info

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GENE：LIF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LIF
FullNmae LIF interleukin 6 family cytokine
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6596
EnsembleID ENSG00000128342
Uniprot P15018

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LIF immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LIF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LIF GO:0000902,GO:0001666,GO:0001974,GO:0005102,GO:0005125,GO:0005125,GO:0005146,GO:0005146,GO:0005146,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005829,GO:0006955,GO:0007566,GO:0008083,GO:0008083,GO:0008284,GO:0008284,GO:0008285,GO:0010467,GO:0010628,GO:0030225,GO:0033138,GO:0033141,GO:0033630,GO:0035019,GO:0042531,GO:0043410,GO:0045595,GO:0045651,GO:0045835,GO:0045944,GO:0045944,GO:0046697,GO:0046888,GO:0048144,GO:0048146,GO:0048286,GO:0048644,GO:0048666,GO:0048711,GO:0048861,GO:0048861,GO:0048863,GO:0050731,GO:0060426,GO:0060463,GO:0060707,GO:0070373,GO:0072108,GO:0072307,GO:0097696,GO:0140013

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LIF hsa:3976 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
LIF hsa:3976 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
LIF hsa:3976 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
LIF hsa:3976 path:hsa04668 TNF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR LIF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LIF 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
EGR1 LIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR2 LIF 24007274 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 LIF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B7E30 LIF 22080513 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000134ADC LIF 19011087 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000134ADC LIF 19011087 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 LIF 19011087 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000B7E30 LIF 22080513 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 LIF 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 LIF 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000007A060 LIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000011DF LIF 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA LIF 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD LIF 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D LIF 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000353492 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000105D19 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000122F23 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CC4BD LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004B4B85 LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000031BC7D LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC LIF 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005D12AC LIF 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000079F78 LIF 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LIF LIFR 25361965 interaction type N/A PTMCode2
LIFR LIF 25361965 interaction type N/A PTMCode2
LIF IL6ST 25361965 interaction type N/A PTMCode2
IL6ST LIF 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCALD LIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT31 LIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HPGDS LIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL6ST LIF 12707269 14525934 14527405 16051226 24234451 25348397 N/A experimental interaction detection,pull down,x-ray crystallography,in vivo ComPPI,HPRD,IntAct
LIF LIFR 12601009 14525934 16051226 24234451 25348397 N/A affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,biochemical,in vitro ComPPI,HPRD,IntAct
LIF KRTAP12-3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LIF IL6ST 12707269 14527405 16051226 27898060 9143707 stimulant N/A OmniPath
LIF LIFR 12601009 16051226 24710148 27898060 8662595 8999038 9143707 9716487 9852103 stimulant N/A OmniPath
TP53 LIF 18431400 27898060 stimulant N/A OmniPath

Visualization










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