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GENE：MAP3K20

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K20
FullNmae mitogen-activated protein kinase kinase kinase 20
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17797
EnsembleID ENSG00000091436
Uniprot Q9NYL2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K20 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K20 GO:0000077,GO:0000287,GO:0003723,GO:0004674,GO:0004674,GO:0004706,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006468,GO:0007010,GO:0007059,GO:0007254,GO:0008219,GO:0018105,GO:0030071,GO:0030154,GO:0030295,GO:0031098,GO:0038066,GO:0042733,GO:0043022,GO:0043065,GO:0043068,GO:0046777,GO:0051403,GO:0060173,GO:0070181,GO:0070269,GO:0071480,GO:0071493,GO:0106310,GO:0140469,GO:1904291

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K20 hsa:51776 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP2K4 MAP3K20 11836244 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K7 MAP3K20 11836244 15465036 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
MAP2K6 MAP3K20 11836244 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP3K20 TGFBR1 15465036 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAZ MAP3K20 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
RPS6KA5 MAP3K20 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MAP3K20 MAP2K7 11836244 23331499 stimulation N/A SignaLink,SignaLink
MAP3K20 MAP2K5 11042189 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K4 11836244 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K3 11836244 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K6 11836244 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP3K20 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYCN MAP3K20 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MAP3K20 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 MAP3K20 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K20 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MAP3K20 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink

Source Target Pmid Interactiontype Methods Database
URS000036AFF1 MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D MAP3K20 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K20 MAP3K20 22135298 phosphorylation N/A PhosphoSite
MAP3K20 CHEK2 22135298 phosphorylation N/A PhosphoSite
MAP3K20 H3C1 22135298 phosphorylation N/A PhosphoSite
MAP3K20 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAP3K20 25361965 interaction type N/A PTMCode2
PKN1 MAP3K20 25361965 interaction type N/A PTMCode2
MAP3K20 PKN1 25361965 interaction type N/A PTMCode2
ZNF33A MAP3K20 25361965 interaction type N/A PTMCode2
MAP3K20 ZNF33A 25361965 interaction type N/A PTMCode2
MALT1 MAP3K20 25361965 interaction type N/A PTMCode2
MAP3K20 MALT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZFP2 MAP3K20 25348397 N/A physical interaction ComPPI
CDC42 MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAG MAP3K20 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
ZNF544 MAP3K20 25348397 N/A physical interaction ComPPI
EMC2 MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EZH2 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPL10 MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UNC119 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKN1 MAP3K20 25348397 N/A anti tag coimmunoprecipitation ComPPI
RBX1 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAB MAP3K20 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ MAP3K20 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
XRCC1 MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K4 MAP3K20 11836244 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MYC MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO1 MAP3K20 25348397 N/A physical interaction ComPPI
SMARCB1 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD4L MAP3K20 25348397 N/A physical interaction ComPPI
ZNF227 MAP3K20 25348397 N/A physical interaction ComPPI
ITSN1 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SFN MAP3K20 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RPS6KA5 MAP3K20 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
MAP2K6 MAP3K20 11836244 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP3K20 MAP2K7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAP3K20 ZNF33A 12535642 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP3K20 ZNF567 14525934 16189514 21516116 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAP3K20 TGFBR1 14525934 15465036 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MAP3K20 MIDN 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 MPP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 VPS33B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 ZNF775 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 ZNF746 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 CCDC69 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 RNF19A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 CRMP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 ELAVL1 25348397 N/A physical interaction ComPPI
MAP3K20 SRPK2 25348397 N/A physical interaction ComPPI
MAP3K20 ZWINT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K20 ZNF71 25348397 N/A physical interaction ComPPI
MAP3K20 IGHM 21900206 24234451 25348397 physical association two hybrid ComPPI,IntAct
MAP3K20 MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DDAH2 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZNF593 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K20 MAP3K20 10924358 14525934 15485649 17192257 24234451 acetylation reaction anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
MKI67 MAP3K20 24234451 26949251 association anti tag coimmunoprecipitation IntAct
RPS6KA5 MAP3K20 21988832 27898060 N/A N/A OmniPath
MAP3K20 CHEK2 15342622 16311512 16481012 27898060 N/A N/A OmniPath
STK11 MAP3K20 15342622 27898060 N/A N/A OmniPath
MAP3K20 MAP2K4 11416147 11836244 27898060 stimulant N/A OmniPath
YWHAZ MAP3K20 21988832 27898060 N/A N/A OmniPath
MAP3K20 MAP2K3 11836244 27898060 stimulant N/A OmniPath
MAP3K20 MAP2K6 11836244 27898060 stimulant N/A OmniPath
MAP3K20 MAP2K5 11042189 27898060 stimulant N/A OmniPath
MAP3K20 MAP2K7 11416147 11836244 12220515 15465036 27898060 stimulant N/A OmniPath
MAP3K20 TGFBR1 15465036 27898060 N/A N/A OmniPath
PKN1 MAP3K20 17251915 27898060 stimulant N/A OmniPath

Visualization










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