GENE：MAPK8IP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAPK8IP1 |
| FullNmae | mitogen-activated protein kinase 8 interacting protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6882 |
| EnsembleID | ENSG00000121653 |
| Uniprot | Q9UQF2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAPK8IP1 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK8IP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK8IP1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK8IP1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAPK8IP1 | GO:0004860,GO:0005078,GO:0005078,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006355,GO:0007254,GO:0008432,GO:0016192,GO:0019894,GO:0030425,GO:0031966,GO:0043025,GO:0043508,GO:0044302,GO:0045202,GO:0046328,GO:0046330,GO:0048471,GO:2000564,GO:2001243 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAPK8IP1 | hsa:9479 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DUSP16 | MAPK8IP1 | 12524447 23180781 23331499 | stimulation,physical association | anti tag coimmunoprecipitation | InnateDB,SignaLink |
| APP | MAPK8IP1 | 12917434 23180781 | physical association | gst pull down | InnateDB |
| AKT1 | MAPK8IP1 | 15998799 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK8IP1 | MAPK8 | 15998799 23180781 23331499 9922370 | stimulation,physical association | anti tag coimmunoprecipitation | InnateDB,SignaLink |
| MAPK8IP1 | MAPK9 | 15998799 23180781 | phosphorylation reaction,physical association | anti tag coimmunoprecipitation,in-gel kinase assay | InnateDB |
| MAPK8IP1 | MAPT | 19491104 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| KLC1 | MAPK8IP1 | 19491104 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK8IP1 | MAPK8IP1 | 10490659 10702297 1143283 15141161 18486448 26467481 9922370 | bind,down-regulates | N/A | Signor |
| MAPK8IP1 | MAP3K10 | 10490659 23331499 9868371 | stimulation | N/A | SignaLink |
| MAPK8IP1 | MAP3K12 | 10490659 23331499 9868371 | stimulation | N/A | SignaLink |
| MAPK8IP1 | MAP2K7 | 10490659 23331499 9868371 | stimulation | N/A | SignaLink |
| MAPK8IP1 | MAP4K1 | 23331499 9868371 | stimulation | N/A | SignaLink |
| SH3RF1 | MAPK8IP1 | 16571722 23331499 | stimulation | N/A | SignaLink |
| INPPL1 | MAPK8IP1 | 18486448 23331499 | stimulation | N/A | SignaLink |
| MAP3K13 | MAPK8IP1 | 11726277 23331499 | interaction type | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK8IP1 | MAP2K7 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAP3K13 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAP3K7 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | ERBB2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| MAPK8IP1 | ITGB3 | 20005715 | interaction type | N/A | PSP,SignaLink |
| MAPK8IP1 | ITGB2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| MAPK8IP1 | ITGB7 | 20005715 | interaction type | N/A | PSP,SignaLink |
| MAPK8IP1 | AKT1 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAPK8 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAPK9 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAP3K10 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAP3K12 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | MAP3K11 | 20005715 | interaction type | N/A | PSP |
| MAPK8IP1 | DUSP16 | 20005715 | interaction type | N/A | PSP,SignaLink |
| MAPK8IP1 | MAP3K13 | 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | AKT1 | 12194869 12194869 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAP2K7 | 20005715 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAP3K10 | 20005715 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAP3K11 | 10490659 10490659 10490659 16456539 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAP3K12 | 20005715 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAP3K7 | 18286207 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAPK8 | 20005715 20005715 | N/A | N/A | SignaLink |
| MAPK8IP1 | MAPK9 | 10490659 10490659 10490659 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | MAPK8IP1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | MAPK8IP1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MAPK8IP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAPK8IP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MAPK8IP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000134ADC | MAPK8IP1 | 16822819 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002B2B5C | MAPK8IP1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000321A1A | MAPK8IP1 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016D2D4 | MAPK8IP1 | 25416803 28454224 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK9 | MAPK8IP1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK8 | MAPK8IP1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| DUSP16 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | DUSP16 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAP3K10 | 25361965 | interaction type | N/A | PTMCode2 |
| MAP3K10 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | APLP2 | 25361965 | interaction type | N/A | PTMCode2 |
| APLP2 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | LRP2 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP2 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAP3K13 | 25361965 | interaction type | N/A | PTMCode2 |
| MAP3K13 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | AKT1 | 25361965 | interaction type | N/A | PTMCode2 |
| AKT1 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | APP | 25361965 | interaction type | N/A | PTMCode2 |
| APP | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | LRP8 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP8 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAP3K11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAP3K11 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAPK8 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAPK8IP2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP2 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | VRK2 | 25361965 | interaction type | N/A | PTMCode2 |
| VRK2 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAPK10 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK10 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | MAP2K7 | 25361965 | interaction type | N/A | PTMCode2 |
| MAP2K7 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK8IP1 | KLC1 | 25361965 | interaction type | N/A | PTMCode2 |
| KLC1 | MAPK8IP1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK9 | MAPK8IP1 | 10490659 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SOCS3 | MAPK8IP1 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB2 | MAPK8IP1 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| TIAM1 | MAPK8IP1 | 12024021 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8 | MAPK8IP1 | 12756254 14525934 16840345 18286207 24234451 25348397 9733513 | association,physical association | experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| JUN | MAPK8IP1 | 25348397 | N/A | physical interaction | ComPPI |
| PAX2 | MAPK8IP1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| CANX | MAPK8IP1 | 18286207 24234451 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| ITGB3 | MAPK8IP1 | 12606711 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| MAP3K10 | MAPK8IP1 | 10490659 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8IP3 | MAPK8IP1 | 10629060 14525934 16456539 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| LRP1 | MAPK8IP1 | 10827173 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| LRP8 | MAPK8IP1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP16 | MAPK8IP1 | 12524447 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MAPK8IP1 | KLC1 | 11238452 11907332 12893827 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| MAPK8IP1 | MAP2K7 | 16840345 18286207 24234451 25348397 | association,physical association | molecular sieving,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| MAPK8IP1 | MAP3K13 | 11726277 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8IP1 | MAPK8IP2 | 10490659 10629060 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MAPK8IP1 | RECQL5 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| MAPK8IP1 | MAP3K11 | 10490659 14525934 16456539 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8IP1 | MAP3K12 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| MAPK8IP1 | VRK2 | 14525934 18286207 25348397 | N/A | experimental interaction detection,molecular sieving,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MAPK8IP1 | MAP3K7 | 14525934 16840345 17709393 18286207 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| MAPK8IP1 | SNCA | 11790792 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| MAPK8IP1 | AKT1 | 12194869 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAPK8IP1 | LRP2 | 10827173 14525934 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| MAPK8IP1 | APP | 11517249 11724784 12893827 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| MAPK8IP1 | MAP2K3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | TAB1 | 18286207 24234451 25348397 | association | molecular sieving,physical interaction | ComPPI,IntAct |
| MAPK8IP1 | EGFR | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| MAPK8IP1 | TTLL4 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | ANK3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | FEM1B | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | HOXC8 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | ANK2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | SENP5 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | SETX | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | MC1R | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | TUBB3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK8IP1 | MAPK8IP1 | 10490659 14525934 16456539 18286207 24234451 | physical association | experimental interaction detection,molecular sieving | HPRD,IntAct |
| CASP3 | MAPK8IP1 | 21237154 27898060 | N/A | N/A | OmniPath |
| LCK | MAPK8IP1 | 12756254 16195223 27898060 | N/A | N/A | OmniPath |
| SOCS3 | MAPK8IP1 | 18055217 27898060 | inhibition | N/A | OmniPath |
| MAPK9 | MAPK8IP1 | 10490659 12756254 15911620 15998799 16195223 27898060 9733513 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAPK9 | 10490659 12756254 15998799 27898060 9733513 | inhibition | N/A | OmniPath |
| APP | MAPK8IP1 | 11517249 11724784 12893827 12917434 16301330 20205790 27898060 | N/A | N/A | OmniPath |
| MAPK8IP1 | APP | 11517249 11724784 12893827 12917434 16301330 20205790 27898060 | N/A | N/A | OmniPath |
| AKT1 | MAPK8IP1 | 12194869 15998799 16343492 27898060 | N/A | N/A | OmniPath |
| SH3RF1 | MAPK8IP1 | 16571722 27898060 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAP2K4 | 27898060 9733513 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAPK14 | 12024021 27898060 | stimulant | N/A | OmniPath |
| MAPK8IP1 | RBPJ | 20508646 27898060 | inhibition | N/A | OmniPath |
| MAPK8IP1 | NOTCH1 | 20508646 27898060 | inhibition | N/A | OmniPath |
| MAPK8IP1 | MAPT | 19491104 27898060 | N/A | N/A | OmniPath |
| MAPK8IP1 | MAP2K7 | 10490659 16456539 16840345 18286207 27898060 9733513 9868371 | stimulant | N/A | OmniPath |
| MAPK8IP1 | TIAM1 | 12024021 27898060 | stimulant | N/A | OmniPath |
| MAPK8 | MAPK8IP1 | 10490659 11700324 12756254 15141161 15314024 15998799 16343492 16533805 16840345 18286207 18486448 27898060 9733513 9922370 9933567 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAPK8 | 10490659 11700324 12756254 15141161 15314024 15998799 16343492 16533805 16840345 18286207 18486448 27898060 9235893 9733513 9922370 9933567 | inhibition,stimulant | N/A | OmniPath |
| DUSP16 | MAPK8IP1 | 12524447 27898060 | stimulant | N/A | OmniPath |
| MAPK8IP1 | DUSP16 | 12524447 27898060 | N/A | N/A | OmniPath |
| MAPK8IP1 | MAP3K10 | 10490659 15767678 27898060 9733513 9868371 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAP4K2 | 10702297 27898060 | inhibition | N/A | OmniPath |
| MAPK8IP2 | MAPK8IP1 | 10490659 10629060 27898060 | stimulant | N/A | OmniPath |
| INPPL1 | MAPK8IP1 | 18486448 27898060 | stimulant | N/A | OmniPath |
| MAPK8IP1 | KLC1 | 11238452 11907332 12893827 19491104 27898060 | N/A | N/A | OmniPath |
| MAP3K13 | MAPK8IP1 | 11726277 27898060 | N/A | N/A | OmniPath |
| MAPK8IP1 | DLK1 | 27898060 9733513 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAP4K1 | 27898060 9868371 | stimulant | N/A | OmniPath |
| MAPK8IP1 | RASGRF1 | 12024021 27898060 | stimulant | N/A | OmniPath |
| MAPK8IP1 | MAP3K12 | 10490659 11432832 27898060 | inhibition | N/A | OmniPath |