Gene Information gene info

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GENE：MUS81

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MUS81
FullNmae MUS81 structure-specific endonuclease subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29814
EnsembleID ENSG00000172732
Uniprot Q96NY9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MUS81 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MUS81 GO:0000712,GO:0000727,GO:0003677,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005730,GO:0006281,GO:0006302,GO:0006308,GO:0008821,GO:0031297,GO:0031573,GO:0033687,GO:0043596,GO:0046872,GO:0048257,GO:0048257,GO:0048476,GO:0072429,GO:1905347

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MUS81 hsa:80198 path:hsa03440 Homologous recombination - Homo sapiens (human)
MUS81 hsa:80198 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MUS81 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NR1I2 MUS81 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MUS81 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MUS81 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MUS81 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MUS81 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
NPM1 MUS81 25348397 N/A physical interaction ComPPI
TP53BP1 MUS81 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
H2BC4 MUS81 25348397 N/A physical interaction ComPPI
MUS81 CHEK2 11073977 11741546 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MUS81 EME1 12686547 12721304 14525934 17289582 19017809 19596236 24234451 24733841 25348397 dna cleavage,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,enzymatic study,in vitro,gal4 vp16 complementation,nuclease assay ComPPI,HPRD,IntAct
MUS81 SLX4 14525934 19596235 19596236 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vivo,confocal microscopy,two hybrid prey pooling approach ComPPI,HPRD,IntAct
MUS81 TERF2 25348397 N/A physical interaction ComPPI
MUS81 SLX1A 19596235 19596236 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MUS81 EME2 17289582 24234451 25348397 dna cleavage,physical association pull down,physical interaction,nuclease assay ComPPI,IntAct
MUS81 WEE1 25348397 N/A physical interaction ComPPI
MUS81 FBXL5 25348397 N/A physical interaction ComPPI
MUS81 PLK1 25348397 N/A physical interaction ComPPI
MUS81 SUMO2 25348397 N/A physical interaction ComPPI
MUS81 UHRF1 25348397 N/A physical interaction ComPPI
MUS81 H2BC11 25348397 N/A physical interaction ComPPI
MUS81 HERC2 25348397 N/A physical interaction ComPPI
MUS81 HERC2P3 25348397 N/A physical interaction ComPPI
MUS81 HNRNPU 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MUS81 RPL10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MUS81 SORT1 25348397 N/A physical interaction ComPPI
MUS81 ERCC1 25348397 N/A physical interaction ComPPI
MUS81 ERCC4 25348397 N/A physical interaction ComPPI
MUS81 DIS3 25348397 N/A physical interaction ComPPI
MUS81 DCAF1 24234451 24412650 25348397 physical association cosedimentation through density gradient,physical interaction ComPPI,IntAct
MUS81 DDB1 25348397 N/A physical interaction ComPPI
MUS81 FEN1 22551069 24234451 25348397 27898060 colocalization,association,physical association anti tag coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct,OmniPath
MUS81 BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
MUS81 MUS81 12686547 14525934 N/A experimental interaction detection HPRD
CDS1 MUS81 11073977 15805465 21084840 27898060 N/A N/A OmniPath
MUS81 RAD54L2 10905349 19129197 27898060 N/A N/A OmniPath
RAD54L MUS81 19017809 27898060 stimulant N/A OmniPath
DCLRE1B MUS81 18469862 27898060 stimulant N/A OmniPath

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