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GENE：NTHL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NTHL1
FullNmae nth like DNA glycosylase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8028
EnsembleID ENSG00000065057
Uniprot P78549

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NTHL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NTHL1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NTHL1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NTHL1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
NTHL1 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
NTHL1 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NTHL1 GO:0000703,GO:0000703,GO:0003684,GO:0003690,GO:0003906,GO:0003906,GO:0004519,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005739,GO:0006285,GO:0006285,GO:0006289,GO:0008534,GO:0019104,GO:0045008,GO:0046872,GO:0051539,GO:0140078

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NTHL1 hsa:4913 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR NTHL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NTHL1 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 NTHL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 NTHL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC NTHL1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NTHL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NTHL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NTHL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NTHL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 NTHL1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MRM3 NTHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL10 NTHL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 NTHL1 25348397 N/A physical interaction ComPPI
RPA2 NTHL1 25348397 N/A physical interaction ComPPI
RPA3 NTHL1 25348397 N/A physical interaction ComPPI
EGFR NTHL1 25348397 N/A physical interaction ComPPI
MMS19 NTHL1 25348397 N/A physical interaction ComPPI
ERCC5 NTHL1 14525934 25348397 9927729 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SRPK2 NTHL1 25348397 N/A physical interaction ComPPI
HECW2 NTHL1 25348397 N/A physical interaction ComPPI
CAMKK1 NTHL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL1 NTHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NTHL1 NUDT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NTHL1 GAPDHS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NTHL1 ZC3HAV1 25348397 N/A physical interaction ComPPI
NTHL1 MOV10 25348397 N/A physical interaction ComPPI
NTHL1 NXF1 25348397 N/A physical interaction ComPPI

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