GENE：PIK3AP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PIK3AP1 |
| FullNmae | phosphoinositide-3-kinase adaptor protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30034 |
| EnsembleID | ENSG00000155629 |
| Uniprot | Q6ZUJ8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PIK3AP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PIK3AP1 | GO:0005102,GO:0005515,GO:0005829,GO:0005829,GO:0005886,GO:0016020,GO:0034134,GO:0034142,GO:0034154,GO:0034162,GO:0036312,GO:0036312,GO:0042802,GO:0050727,GO:0051897 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PIK3AP1 | hsa:118788 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| PIK3AP1 | hsa:118788 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| REL | PIK3AP1 | 18245482 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| PIK3AP1 | POLR2F | 23180781 23994473 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PIK3CD | PIK3AP1 | 24243840 29145629 | physical association | inferred by curator | Reactome |
| PIK3R1 | PIK3AP1 | 24243840 29145629 | physical association | inferred by curator | Reactome |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PIK3AP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | PIK3AP1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | PIK3AP1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | PIK3AP1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PIK3AP1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PIK3AP1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PIK3AP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PIK3AP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ABL1 | PIK3AP1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCK2 | PIK3AP1 | 25348397 | N/A | physical interaction | ComPPI |
| BTK | PIK3AP1 | 11163197 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SYK | PIK3AP1 | 11163197 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PIK3R1 | PIK3AP1 | 11163197 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GRB2 | PIK3AP1 | 21706016 21988832 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| PIK3AP1 | ITSN1 | 18654987 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PIK3AP1 | ITSN2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3AP1 | WNT7A | 25348397 | N/A | physical interaction | ComPPI |
| PIK3AP1 | HTN3 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3AP1 | PIK3CA | 22187458 27898060 | stimulant | N/A | OmniPath |
| ABL1 | PIK3AP1 | 15893754 17693683 18083107 20841568 27898060 | N/A | N/A | OmniPath |
| PIK3AP1 | PIK3R1 | 11163197 22187458 27898060 | stimulant | N/A | OmniPath |
| PIK3AP1 | PIK3CB | 22187458 27898060 | stimulant | N/A | OmniPath |
| PIK3AP1 | PIK3CG | 22187458 27898060 | stimulant | N/A | OmniPath |