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GENE：PPP1R12A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP1R12A
FullNmae protein phosphatase 1 regulatory subunit 12A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7618
EnsembleID ENSG00000058272
Uniprot O14974

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP1R12A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP1R12A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP1R12A ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP1R12A GO:0000278,GO:0000776,GO:0004857,GO:0004857,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005829,GO:0005886,GO:0005925,GO:0006470,GO:0007098,GO:0007165,GO:0015629,GO:0019208,GO:0019208,GO:0019208,GO:0019901,GO:0030018,GO:0030018,GO:0030155,GO:0031672,GO:0031672,GO:0035507,GO:0035508,GO:0035508,GO:0043086,GO:0043292,GO:0045944,GO:0046822,GO:0071466,GO:0071889,GO:0072357

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP1R12A hsa:4659 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04510 Focal adhesion - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04611 Platelet activation - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PPP1R12A hsa:4659 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL16 PPP1R12A 12923170 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR PPP1R12A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PPP1R12A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PPP1R12A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PPP1R12A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PPP1R12A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PPP1R12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 PPP1R12A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PPP1R12A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C PPP1R12A 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS0000065D58 PPP1R12A 18668040 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00000DDD35 PPP1R12A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 PPP1R12A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000048B5E9 PPP1R12A 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001383CF PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 PPP1R12A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 PPP1R12A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F PPP1R12A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PPP1R12A 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAF1 PPP1R12A 22135298 phosphorylation N/A PhosphoSite
PRKCQ PPP1R12A 22135298 phosphorylation N/A PhosphoSite
ROCK1 PPP1R12A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK2 PPP1R12A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
NUAK1 PPP1R12A 22135298 phosphorylation N/A PhosphoSite
PPP1R12A PPP1CA 25361965 interaction type N/A PTMCode2
PPP1CA PPP1R12A 25361965 interaction type N/A PTMCode2
PPP1R12A ILK 25361965 interaction type N/A PTMCode2
ILK PPP1R12A 25361965 interaction type N/A PTMCode2
PPP1R12A ROCK2 25361965 interaction type N/A PTMCode2
PPP1R12A DMPK 25361965 interaction type N/A PTMCode2
DMPK PPP1R12A 25361965 interaction type N/A PTMCode2
PPP1R12A PRKG1 25361965 interaction type N/A PTMCode2
PRKG1 PPP1R12A 25361965 interaction type N/A PTMCode2
PPP1R12A ROCK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TPP2 PPP1R12A 25348397 N/A physical interaction ComPPI
YWHAG PPP1R12A 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP1CB PPP1R12A 17353931 24234451 25348397 26496610 27173435 28330616 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring ComPPI,IntAct
RAN PPP1R12A 24234451 24855949 25348397 physical association pull down ComPPI,IntAct
ROCK1 PPP1R12A 10601309 11931630 12220642 12563012 12600888 14525934 25348397 9354661 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KEAP1 PPP1R12A 25348397 N/A physical interaction ComPPI
JUNB PPP1R12A 25348397 N/A physical interaction ComPPI
CRK PPP1R12A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 PPP1R12A 19744480 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GRB2 PPP1R12A 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN PPP1R12A 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 PPP1R12A 18850735 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RHOA PPP1R12A 14525934 15545284 24234451 25348397 9354661 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FLNA PPP1R12A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A ILK 10601309 11931630 12220642 12600888 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP1R12A IL16 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PPP1R12A ROCK2 10601309 11931630 12220642 12563012 12600888 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP1R12A DMPK 10601309 11287000 11931630 12220642 12600888 14525934 21457715 24234451 25348397 phosphorylation reaction experimental interaction detection,protein kinase assay,in vitro ComPPI,HPRD,IntAct
PPP1R12A MPRIP 14525934 15545284 16243315 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
PPP1R12A HDAC7 25348397 N/A physical interaction ComPPI
PPP1R12A KDM1A 21115810 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PPP1R12A SETD7 25348397 N/A physical interaction ComPPI
PPP1R12A ELAVL1 25348397 N/A physical interaction ComPPI
PPP1R12A ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A FBXO25 25348397 N/A physical interaction ComPPI
PPP1R12A ATXN10 25348397 N/A physical interaction ComPPI
PPP1R12A LRRK2 25348397 N/A physical interaction ComPPI
PPP1R12A CDV3 25348397 N/A physical interaction ComPPI
PPP1R12A IDH3G 25348397 N/A physical interaction ComPPI
PPP1R12A PAXIP1 25348397 N/A physical interaction ComPPI
PPP1R12A FMNL1 25348397 N/A physical interaction ComPPI
PPP1R12A PAN2 25348397 N/A physical interaction ComPPI
PPP1R12A LATS1 25348397 N/A physical interaction ComPPI
PPP1R12A AARSD1 25348397 N/A physical interaction ComPPI
PPP1R12A ACTR3 25348397 N/A physical interaction ComPPI
PPP1R12A ARPC2 25348397 N/A physical interaction ComPPI
PPP1R12A CUL1 25348397 N/A physical interaction ComPPI
PPP1R12A P3H1 25348397 N/A physical interaction ComPPI
PPP1R12A NRDC 25348397 N/A physical interaction ComPPI
PPP1R12A NSUN2 25348397 N/A physical interaction ComPPI
PPP1R12A NUDT5 25348397 N/A physical interaction ComPPI
PPP1R12A NUSAP1 25348397 N/A physical interaction ComPPI
PPP1R12A OSGEP 25348397 N/A physical interaction ComPPI
PPP1R12A PFDN1 25348397 N/A physical interaction ComPPI
PPP1R12A PFDN5 25348397 N/A physical interaction ComPPI
PPP1R12A RPRD1B 25348397 N/A physical interaction ComPPI
PPP1R12A XPO5 25348397 N/A physical interaction ComPPI
PPP1R12A PUS1 25348397 N/A physical interaction ComPPI
PPP1R12A TRIM47 25348397 N/A physical interaction ComPPI
PPP1R12A TTLL12 25348397 N/A physical interaction ComPPI
PPP1R12A RPA3 25348397 N/A physical interaction ComPPI
PPP1R12A RPA2 25348397 N/A physical interaction ComPPI
PPP1R12A NUAK1 25348397 N/A physical interaction ComPPI
PPP1R12A TP53 25348397 N/A physical interaction ComPPI
PPP1R12A LUZP4 25348397 N/A physical interaction ComPPI
PPP1R12A FKBP6 25348397 N/A physical interaction ComPPI
PPP1R12A PHF7 25348397 N/A physical interaction ComPPI
PPP1R12A CDK8 25348397 N/A physical interaction ComPPI
PPP1R12A NTRK1 25348397 N/A physical interaction ComPPI
PPP1R12A MED23 25348397 N/A physical interaction ComPPI
PPP1R12A RPGRIP1L 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A CDK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A MYO1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A ACTR2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A MYO5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A MYO18A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A FOS 20195357 24234451 25348397 25609649 association,physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
PPP1R12A CDKN3 25348397 N/A physical interaction ComPPI
PPP1R12A SERPINB2 25348397 N/A physical interaction ComPPI
PPP1R12A NUAK2 25348397 N/A physical interaction ComPPI
PPP1R12A SH3BP5L 25348397 N/A physical interaction ComPPI
PPP1R12A TULP3 25348397 N/A physical interaction ComPPI
PPP1R12A HNRNPL 25348397 N/A physical interaction ComPPI
PPP1R12A CFTR 25348397 N/A physical interaction ComPPI
PPP1R12A HIF1AN 17003112 24234451 25348397 hydroxylation reaction hydroxylation reaction,hydroxylase assay ComPPI,IntAct
PPP1R12A MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1R12A RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1R12A FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PPP1R12A PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PPP1R12A PRKAR1A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PPP1R12A YWHAZ 18094049 24234451 25348397 27898060 association coimmunoprecipitation ComPPI,IntAct,OmniPath
PPP1R12A MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PPP1R12A PARK7 24234451 24947010 25348397 association tandem affinity purification ComPPI,IntAct
PPP1R12A DAPK3 15292222 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PPP1R12A TRPM2 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP1R12A SPECC1L 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP1R12A TRDMT1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP1R12A CLTCL1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP1R12A RAI14 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP1R12A METTL17 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP1R12A TRIOBP 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP1R12A PPP1R12C 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP1R12A UACA 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP1R12A PPP1R12B 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP1R12A KSR2 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R12A PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
PPP1R12A PPP1CA 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKG1 PPP1R12A 10567269 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RPA1 PPP1R12A 25348397 N/A physical interaction ComPPI
IQGAP1 PPP1R12A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZNF263 PPP1R12A 25348397 N/A physical interaction ComPPI
HSP90B1 PPP1R12A 24234451 30021884 physical association cross-linking study IntAct
RPN1 PPP1R12A 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PPP1R12A 24234451 25702638 association anti bait coimmunoprecipitation IntAct
ROCK1 PPP1R12A 10601309 10926869 11384979 11719507 11739394 11931630 12220642 12563012 12600888 12919947 15003930 15281089 15723050 17525332 18077418 18212344 18669648 18767875 19701943 19997641 27898060 8662509 9354661 inhibition,stimulant N/A OmniPath
PRKCQ PPP1R12A 12563012 14709404 15226371 15665056 16038801 16130142 16219803 16421202 17085525 17110524 17158339 18648664 19470783 24610576 26215804 27898060 N/A N/A OmniPath
NUAK1 PPP1R12A 18088087 18669648 19367720 19413330 19690332 20354225 22516431 24785407 27898060 inhibition N/A OmniPath
CDK1 PPP1R12A 18477460 18669648 27898060 N/A N/A OmniPath
ROCK2 PPP1R12A 10601309 11331307 11931630 12220642 12563012 12600888 27898060 inhibition N/A OmniPath
DAPK3 PPP1R12A 11226254 15292222 27898060 inhibition N/A OmniPath
ILK PPP1R12A 10601309 11931630 12030846 12220642 12600888 18077418 18212344 18669648 18767875 27898060 inhibition,stimulant N/A OmniPath
CAMK4 PPP1R12A 12919947 27898060 N/A N/A OmniPath
DMPK PPP1R12A 10601309 11287000 11931630 12220642 12600888 18077418 18212344 18669648 18767875 21457715 27898060 stimulant N/A OmniPath

Visualization










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