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GENE：PRNP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRNP
FullNmae prion protein (Kanno blood group)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9449
EnsembleID ENSG00000171867
Uniprot F7VJQ1|P04156

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRNP mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRNP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRNP ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRNP ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PRNP cuproptosis 36980514 Through the PPI network and immune infiltration analysis, we found that PRNP was the key CRCG(cuproptosis-related characteristic gene). retulator signature
PRNP cuproptosis 38408075 We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1. genes involved in Cuproptosis
PRNP cuproptosis 38408075 We showed the mechanism of action of these genes in Cuproptosis. Excess Cu2+ stimulates the activation of ATM which activates SP1 and P53. P53 promotes PRNP, MT1A, MT2A and MT3A to expel Cu2+ out of the cell. suppressor
PRNP cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
PRNP cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.20 database.
PRNP cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.42 database.

Go Annotation:

GeneSymbol Go id
PRNP GO:0001540,GO:0001540,GO:0001540,GO:0001540,GO:0001933,GO:0002020,GO:0005507,GO:0005507,GO:0005515,GO:0005521,GO:0005539,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006878,GO:0006979,GO:0007049,GO:0007611,GO:0007616,GO:0008017,GO:0009897,GO:0009986,GO:0009986,GO:0010955,GO:0014069,GO:0014069,GO:0015631,GO:0016234,GO:0019828,GO:0019898,GO:0030425,GO:0031648,GO:0031802,GO:0031802,GO:0031965,GO:0032689,GO:0032700,GO:0032703,GO:0035584,GO:0038023,GO:0042802,GO:0043008,GO:0043066,GO:0043195,GO:0043231,GO:0043433,GO:0043525,GO:0044325,GO:0044877,GO:0044877,GO:0045121,GO:0045121,GO:0045121,GO:0046007,GO:0046686,GO:0050730,GO:0050731,GO:0050860,GO:0051087,GO:0051260,GO:0051726,GO:0060090,GO:0061098,GO:0070062,GO:0070885,GO:0071280,GO:0071466,GO:0090314,GO:0097062,GO:0098794,GO:0140311,GO:0140677,GO:0140693,GO:1900272,GO:1900449,GO:1901379,GO:1902430,GO:1902938,GO:1902951,GO:1902992,GO:1903078,GO:1903135,GO:1903136,GO:1904645,GO:1904646,GO:1905664,GO:1990535

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRNP hsa:5621 path:hsa04216 Ferroptosis - Homo sapiens (human)
PRNP hsa:5621 path:hsa05020 Prion disease - Homo sapiens (human)
PRNP hsa:5621 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADAM23 PRNP 19477226 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PRNP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 PRNP 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 PRNP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 PRNP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRNP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PRNP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PRNP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PRNP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRNP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYT1 PRNP 18990686 trascriptional regulation,stimulation inferred by curator TFlink
MYT1 PRNP 18990686 trascriptional regulation,stimulation inferred by curator TFlink
MTF1 PRNP 18990686 trascriptional regulation,stimulation inferred by curator TFlink
MTF1 PRNP 18990686 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PRNP 18990686 23131565 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PRNP 18990686 23131565 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PRNP 18990686 23131565 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PRNP 18990686 23131565 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 PRNP 23737521 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 PRNP 23737521 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PRNP N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 PRNP 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000521626 PRNP 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00002C0FCB PRNP 20371350 22100165 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000F31F4 PRNP 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003BBF48 PRNP 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000B59A2 PRNP 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 PRNP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000083D87 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PRNP 22100165 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B PRNP 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000209905 PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000013E79D PRNP 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED PRNP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PRNP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000239117 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0874 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 PRNP 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK5 PRNP 22135298 phosphorylation N/A PhosphoSite
APOE PRNP 25361965 interaction type N/A PTMCode2
PRNP APOE 25361965 interaction type N/A PTMCode2
CAV1 PRNP 25361965 interaction type N/A PTMCode2
PRNP CAV1 25361965 interaction type N/A PTMCode2
PRNP NCAM2 25361965 interaction type N/A PTMCode2
NCAM2 PRNP 25361965 interaction type N/A PTMCode2
CLSTN1 PRNP 25361965 interaction type N/A PTMCode2
PRNP CLSTN1 25361965 interaction type N/A PTMCode2
APP PRNP 25361965 interaction type N/A PTMCode2
PRNP APP 25361965 interaction type N/A PTMCode2
APLP1 PRNP 25361965 interaction type N/A PTMCode2
PRNP APLP1 25361965 interaction type N/A PTMCode2
STIP1 PRNP 25361965 interaction type N/A PTMCode2
PRNP STIP1 25361965 interaction type N/A PTMCode2
MAG PRNP 25361965 interaction type N/A PTMCode2
PRNP MAG 25361965 interaction type N/A PTMCode2
PRNP PRNP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PDE4DIP PRNP 25348397 N/A physical interaction ComPPI
PDE4DIP PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ZNF408 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
HOXA1 PRNP 25348397 N/A physical interaction ComPPI
HOXA1 PRNP 18482256 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,protein array,physical interaction,fluorescence microscopy ComPPI,IntAct
ABT1 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
LMNA PRNP 25348397 N/A physical interaction ComPPI
LMNA PRNP 25348397 N/A physical interaction ComPPI
CSN3 PRNP 25348397 N/A physical interaction ComPPI
CSN3 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
NHP2 PRNP 25348397 N/A physical interaction ComPPI
NHP2 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
GRB2 PRNP 11571277 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PSMA3 PRNP 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PSMA3 PRNP 25348397 N/A physical interaction ComPPI
PLG PRNP 11100730 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CLU PRNP 25348397 N/A physical interaction,in vivo ComPPI
CLU PRNP 15146195 18786636 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HSP90AA1 PRNP 25348397 N/A physical interaction ComPPI
HSP90AA1 PRNP 25348397 N/A physical interaction ComPPI
PRNP L1CAM 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP CAV1 10988071 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP NCAM2 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP DNM1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP APBB1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP ADAM23 14525934 15146195 19477226 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PRNP STIP1 12093732 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRNP SPARCL1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP P4HB 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP CNTN1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP OPCML 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP NECTIN1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP LSAMP 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP CLSTN1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP MOG 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP ERI3 11571277 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP APOE 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP TSC22D4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PRNP NCAM1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP CSNK2A1 11062072 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRNP CSNK2B 11062072 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRNP HSPD1 14525934 25348397 8676499 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRNP BAG6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRNP DPP6 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP HSPA5 14525934 15146195 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRNP MAG 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP APLP1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP APLP2 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRNP SRRM2 25348397 N/A physical interaction ComPPI
PRNP HSPA4 25348397 N/A physical interaction ComPPI
PRNP PIMREG 18482256 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,protein array,physical interaction,fluorescence microscopy ComPPI,IntAct
PRNP BAZ2B 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP SURF2 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP SCNM1 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP TYMSOS 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP RBM22 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP CCDC149 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP MPG 18482256 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,protein array,physical interaction,fluorescence microscopy ComPPI,IntAct
PRNP ZKSCAN8 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP TSLP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP DDX47 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP MARK4 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP RPL41 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP ZNF740 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP CWC15 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP FHL1 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP TMEM237 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP IER3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP KIAA1191 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP ARHGAP15 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP MTG1 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP UTP4 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP AGO1 18482256 22484317 24234451 25348397 physical association anti bait coimmunoprecipitation,protein array,physical interaction ComPPI,IntAct
PRNP ADAP2 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP PPP1R14A 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP CIRBP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP ZFYVE28 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP PYM1 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP PPFIBP2 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP FAM27E3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP FGF13 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP AIFM3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP CNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP NOB1 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP RNPC3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP DYRK3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PRNP PAN2 25348397 N/A physical interaction ComPPI
PRNP TRIM15 25348397 N/A physical interaction ComPPI
PRNP ARF1 25348397 N/A physical interaction ComPPI
PRNP ZBED3 25348397 N/A physical interaction ComPPI
PRNP PABPC1 25348397 N/A physical interaction ComPPI
PRNP PABPC4 25348397 N/A physical interaction ComPPI
PRNP CYLD 25348397 N/A physical interaction ComPPI
PRNP HSP90AA2P 25348397 N/A physical interaction ComPPI
PRNP RPSA 25348397 N/A physical interaction ComPPI
PRNP PSMD2 25348397 N/A physical interaction ComPPI
PRNP AMFR 25348397 N/A physical interaction ComPPI
PRNP AGO2 22484317 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRNP DICER1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PRNP TNRC6A 22484317 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRNP APP 16286452 24028865 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct,OmniPath
PRNP PPARG 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRNP MAPT 24028865 24234451 25348397 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRNP HTT 17500595 24234451 25348397 association pull down ComPPI,IntAct
BAG6 PRNP 25348397 N/A physical interaction ComPPI
STIP1 PRNP 25348397 N/A physical interaction ComPPI
HSPA5 PRNP 25348397 N/A physical interaction ComPPI
PABPC4 PRNP 25348397 N/A physical interaction ComPPI
CSNK2A1 PRNP 25348397 N/A physical interaction ComPPI
IER3 PRNP 25348397 N/A physical interaction ComPPI
PPP1R14A PRNP 25348397 N/A physical interaction ComPPI
MARK4 PRNP 25348397 N/A physical interaction ComPPI
PABPC1 PRNP 25348397 N/A physical interaction ComPPI
YWHAQ PRNP 25348397 N/A physical interaction ComPPI
YWHAQ PRNP 25348397 N/A physical interaction ComPPI
CSNK2A2 PRNP 11062072 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA4 PRNP 25348397 N/A physical interaction ComPPI
PLK3 PRNP 25348397 N/A physical interaction ComPPI
PLK3 PRNP 18482256 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,protein array,physical interaction,fluorescence microscopy ComPPI,IntAct
PSMD2 PRNP 25348397 N/A physical interaction ComPPI
FHL1 PRNP 25348397 N/A physical interaction ComPPI
TSLP PRNP 25348397 N/A physical interaction ComPPI
TBPL1 PRNP 25348397 N/A physical interaction ComPPI
TBPL1 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
AMFR PRNP 25348397 N/A physical interaction ComPPI
ARHGAP15 PRNP 25348397 N/A physical interaction ComPPI
TSC22D4 PRNP 25348397 N/A physical interaction ComPPI
CIRBP PRNP 25348397 N/A physical interaction ComPPI
PPFIBP2 PRNP 25348397 N/A physical interaction ComPPI
SRRM2 PRNP 25348397 N/A physical interaction ComPPI
PAN2 PRNP 25348397 N/A physical interaction ComPPI
AGO1 PRNP 25348397 N/A physical interaction ComPPI
MPG PRNP 25348397 N/A physical interaction ComPPI
RPL41 PRNP 25348397 N/A physical interaction ComPPI
NOB1 PRNP 25348397 N/A physical interaction ComPPI
HSPD1 PRNP 25348397 27898060 8676499 N/A physical interaction ComPPI,OmniPath
RPSA PRNP 25348397 N/A physical interaction ComPPI
ARF1 PRNP 25348397 N/A physical interaction ComPPI
WDR5 PRNP 25348397 N/A physical interaction ComPPI
WDR5 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
CYLD PRNP 25348397 N/A physical interaction ComPPI
SCNM1 PRNP 25348397 N/A physical interaction ComPPI
C7ORF50 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
SURF2 PRNP 25348397 N/A physical interaction ComPPI
ADAP2 PRNP 25348397 N/A physical interaction ComPPI
MTG1 PRNP 25348397 N/A physical interaction ComPPI
PRNP PIMREG 25348397 N/A physical interaction ComPPI
PRNP RBM22 25348397 N/A physical interaction ComPPI
PRNP CCDC149 25348397 N/A physical interaction ComPPI
PRNP DDX47 25348397 N/A physical interaction ComPPI
PRNP ZNF740 25348397 N/A physical interaction ComPPI
PRNP CWC15 25348397 N/A physical interaction ComPPI
PRNP UTP4 25348397 N/A physical interaction ComPPI
PRNP PYM1 25348397 N/A physical interaction ComPPI
PRNP AIFM3 25348397 N/A physical interaction ComPPI
PRNP DYRK3 25348397 N/A physical interaction ComPPI
PRNP ZBED3 25348397 N/A physical interaction ComPPI
PTRH1 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
RNPC3 PRNP 25348397 N/A physical interaction ComPPI
PRNP PRNP 16286452 18025469 18436646 19204296 19278656 19927125 21920025 24234451 colocalization,association,physical association circular dichroism,classical fluorescence spectroscopy,transmission electron microscopy,cosedimentation in solution,electron microscopy,electron paramagnetic resonance,fluorescence technology,light scattering,molecular sieving,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,atomic force microscopy IntAct
ADRB2 PRNP 24234451 28298427 physical association bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
CCR1 PRNP 24234451 28298427 physical association bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
PTAFR PRNP 24234451 28298427 physical association bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
F2RL1 PRNP 24234451 28298427 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
FZD7 PRNP 24234451 28298427 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
PRNP CAV1 10988071 27898060 N/A N/A OmniPath
PRNP PLG 11100730 27898060 N/A N/A OmniPath
PRNP DPP6 15146195 24225951 27898060 N/A N/A OmniPath
CDK5 PRNP 24360565 25572400 27898060 N/A N/A OmniPath
SP1 PRNP 19064990 27898060 stimulant N/A OmniPath

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