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GENE：PSMD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMD4
FullNmae proteasome 26S subunit ubiquitin receptor, non-ATPase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9561
EnsembleID ENSG00000159352
Uniprot P55036

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMD4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMD4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMD4 apoptosis 30930224 The silencing of PSMD4 blocked cell proliferation and tumor growth, induced cell apoptosis and inhibited the proteasome activity. retulator signature

Go Annotation:

GeneSymbol Go id
PSMD4 GO:0000502,GO:0000502,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0005829,GO:0005829,GO:0008540,GO:0022624,GO:0031593,GO:0042802,GO:0043161,GO:0043161,GO:0060090

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMD4 hsa:5710 path:hsa03050 Proteasome - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05020 Prion disease - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PSMD4 hsa:5710 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SQSTM1 PSMD4 15340068 23180781 physical association gst pull down InnateDB
UBC PSMD4 19285159 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PSMD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PSMD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PSMD4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOS PSMD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSMD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE PSMD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PSMD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 PSMD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 PSMD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 PSMD4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
GOLGA2 PSMD4 24234451 25348397 29568061 association pull down ComPPI,IntAct
AIMP2 PSMD4 25348397 N/A physical interaction ComPPI
PSMB10 PSMD4 25348397 N/A physical interaction ComPPI
TPD52L2 PSMD4 25348397 N/A physical interaction ComPPI
CRYAB PSMD4 25348397 N/A physical interaction ComPPI
S100P PSMD4 25348397 N/A physical interaction ComPPI
ATP5F1B PSMD4 25348397 N/A physical interaction ComPPI
NPM1 PSMD4 25348397 N/A physical interaction ComPPI
PSMC3 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD14 PSMD4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 PSMD4 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TRAF6 PSMD4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMD7 PSMD4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP PSMD4 25348397 N/A physical interaction ComPPI
MCM5 PSMD4 25348397 N/A physical interaction ComPPI
NUBP2 PSMD4 25348397 N/A physical interaction ComPPI
PTPN6 PSMD4 25348397 N/A pull down ComPPI
LAGE3 PSMD4 25348397 N/A physical interaction ComPPI
PSMB2 PSMD4 25348397 N/A physical interaction ComPPI
INSIG2 PSMD4 25348397 N/A physical interaction ComPPI
MYH7 PSMD4 25348397 N/A physical interaction ComPPI
SIAH2 PSMD4 25348397 N/A physical interaction ComPPI
MYOD1 PSMD4 14525934 25348397 9235903 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
JUN PSMD4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA3 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 PSMD4 19931242 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
PSMD11 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDIA6 PSMD4 25348397 N/A physical interaction ComPPI
UBB PSMD4 14525934 17662948 24234451 25348397 9488668 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
UBC PSMD4 10921894 12095625 14585839 15826667 16007098 16222312 16497222 16810319 16862145 17368669 19240029 19285159 19796170 19798103 20059542 20542005 23314748 23649778 24234451 25348397 25633294 25666615 27898060 8570649 9488668 physical association far western blotting,pull down,surface plasmon resonance,physical interaction,in vitro ComPPI,IntAct,OmniPath
RPS27A PSMD4 25348397 N/A pull down,physical interaction,in vitro ComPPI
UBA52 PSMD4 25348397 N/A pull down,physical interaction,in vitro ComPPI
DLD PSMD4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 PSMD4 25348397 N/A physical interaction ComPPI
BTRC PSMD4 25348397 N/A physical interaction ComPPI
THBS1 PSMD4 25348397 N/A physical interaction ComPPI
PTPN2 PSMD4 25348397 N/A physical interaction ComPPI
RPA1 PSMD4 25348397 N/A physical interaction ComPPI
POLE PSMD4 25348397 N/A physical interaction ComPPI
MSH6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PSMA1 PSMD4 25348397 N/A physical interaction ComPPI
PSMA6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA5 PSMD4 16990800 24234451 25348397 29426014 physical association anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
PDIA4 PSMD4 25348397 N/A physical interaction ComPPI
PSMB9 PSMD4 25348397 N/A physical interaction ComPPI
MYC PSMD4 17314511 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SREBF2 PSMD4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CAD PSMD4 25348397 N/A physical interaction ComPPI
ITGB2 PSMD4 25348397 N/A physical interaction ComPPI
CFTR PSMD4 25348397 N/A physical interaction ComPPI
MAPK6 PSMD4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD8 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SQSTM1 PSMD4 25348397 N/A physical interaction ComPPI
RELA PSMD4 25348397 N/A physical interaction ComPPI
PSMB8 PSMD4 25348397 N/A physical interaction ComPPI
PSMD1 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ECT2 PSMD4 25348397 N/A physical interaction ComPPI
UBAC1 PSMD4 25348397 N/A physical interaction ComPPI
AHR PSMD4 25348397 N/A physical interaction ComPPI
PSMC5 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCE1 PSMD4 25348397 N/A physical interaction ComPPI
HUWE1 PSMD4 25348397 N/A physical interaction ComPPI
UBQLN2 PSMD4 11827521 14525934 20059542 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
RAD23A PSMD4 10488153 11827521 12970176 14525934 14557549 14621999 16105547 16990800 17408689 19013454 20059542 24234451 25348397 27898060 29997244 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,nuclear magnetic resonance,pull down,surface plasmon resonance,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct,OmniPath
ANKRD13A PSMD4 25348397 N/A physical interaction ComPPI
NEDD4L PSMD4 25348397 N/A physical interaction ComPPI
NEDD8 PSMD4 11585840 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CUL2 PSMD4 25348397 N/A physical interaction ComPPI
MDM2 PSMD4 25348397 N/A physical interaction ComPPI
PCNT PSMD4 17891176 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
CUL1 PSMD4 25348397 N/A physical interaction ComPPI
EGFR PSMD4 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
HTT PSMD4 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
PSMC4 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA4 PSMD4 25348397 N/A physical interaction ComPPI
TRIM63 PSMD4 25348397 N/A physical interaction ComPPI
GNB5 PSMD4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XPC PSMD4 25348397 N/A physical interaction ComPPI
UBQLN4 PSMD4 15280365 18079109 24256120 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP1LC3A PSMD4 25348397 N/A physical interaction ComPPI
NOS2 PSMD4 25348397 N/A physical interaction ComPPI
MDC1 PSMD4 25348397 N/A physical interaction ComPPI
PSMD2 PSMD4 16990800 24234451 25036637 25348397 colocalization,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
ITGA2 PSMD4 25348397 N/A physical interaction ComPPI
ELOC PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ZNF24 PSMD4 25348397 N/A physical interaction ComPPI
RAD23B PSMD4 10488153 14525934 16990800 20059542 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
IDH3A PSMD4 25348397 N/A physical interaction ComPPI
PRKN PSMD4 12634850 15194120 19240029 19875440 20810900 21348451 22350919 22517668 23503661 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ID1 PSMD4 14525934 17891176 24234451 25348397 9235903 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PSMD10 PSMD4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
H3C1 PSMD4 25348397 N/A physical interaction ComPPI
PSMD4 NUB1 11585840 16171779 22434192 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
PSMD4 RASSF8 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSMD4 STUB1 11146632 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PSMD4 UBQLN1 14525934 17082820 20059542 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PSMD4 TCF3 14525934 25348397 9235903 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PSMD4 PSMD13 16990800 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMD6 16990800 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PAX3 25348397 N/A physical interaction ComPPI
PSMD4 UCHL5 17139257 18922472 19490896 19615732 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PSMD4 USP14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 SOD1 25348397 N/A physical interaction ComPPI
PSMD4 ACO2 25348397 N/A physical interaction ComPPI
PSMD4 ALB 25348397 N/A physical interaction ComPPI
PSMD4 ATP5F1A 25348397 N/A physical interaction ComPPI
PSMD4 HADHA 25348397 N/A physical interaction ComPPI
PSMD4 GSN 25348397 N/A physical interaction ComPPI
PSMD4 CKMT2 25348397 N/A physical interaction ComPPI
PSMD4 GOT2 25348397 N/A physical interaction ComPPI
PSMD4 ALDOA 25348397 N/A physical interaction ComPPI
PSMD4 MDH2 25348397 N/A physical interaction ComPPI
PSMD4 MB 25348397 N/A physical interaction ComPPI
PSMD4 TP53 25348397 N/A physical interaction ComPPI
PSMD4 UBE3A 24234451 25348397 29426014 physical association molecular sieving,physical interaction ComPPI,IntAct
PSMD4 NEDD4 19240029 22350919 25348397 26205498 27898060 N/A physical interaction ComPPI,OmniPath
PSMD4 SEM1 25348397 N/A physical interaction ComPPI
PSMD4 UBD 25348397 N/A physical interaction ComPPI
PSMD4 RBCK1 25348397 N/A physical interaction ComPPI
PSMD4 PSMA7 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 AQP4 25348397 N/A physical interaction ComPPI
PSMD4 FLOT1 18164080 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMD4 ABL1 25348397 N/A physical interaction ComPPI
PSMD4 FKBP8 25348397 N/A physical interaction ComPPI
PSMD4 PSMC2 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 UBE2C 25348397 N/A physical interaction ComPPI
PSMD4 FBXO25 25348397 N/A physical interaction ComPPI
PSMD4 PSME3 25348397 N/A physical interaction ComPPI
PSMD4 TXNL1 25348397 N/A physical interaction ComPPI
PSMD4 PSMA2 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMD5 19490896 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 CCNA2 25348397 N/A physical interaction ComPPI
PSMD4 APP 25348397 N/A physical interaction ComPPI
PSMD4 PSMC1 16990800 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMD3 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMD12 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMB7 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMB5 25348397 N/A physical interaction ComPPI
PSMD4 PSMB6 25348397 N/A physical interaction ComPPI
PSMD4 PSMA4 25348397 N/A physical interaction ComPPI
PSMD4 DCTN2 25348397 N/A physical interaction ComPPI
PSMD4 RNF11 25348397 N/A physical interaction ComPPI
PSMD4 SCHIP1 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
PSMD4 FBXO6 25348397 N/A physical interaction ComPPI
PSMD4 GJA1 25348397 N/A physical interaction ComPPI
PSMD4 DIO2 25348397 N/A physical interaction ComPPI
PSMD4 RPS12 25348397 N/A physical interaction ComPPI
PSMD4 SPRTN 25348397 N/A physical interaction ComPPI
PSMD4 NUPR1 16478804 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMD4 UBXN1 25348397 N/A physical interaction ComPPI
PSMD4 MAP3K1 25348397 N/A physical interaction ComPPI
PSMD4 TMEM129 25348397 N/A physical interaction ComPPI
PSMD4 CCDC74B 25348397 N/A physical interaction ComPPI
PSMD4 CCDC92 25348397 N/A physical interaction ComPPI
PSMD4 AHCYL1 25348397 N/A physical interaction ComPPI
PSMD4 ANKRD13B 25348397 N/A physical interaction ComPPI
PSMD4 GFPT1 25348397 N/A physical interaction ComPPI
PSMD4 KIFBP 25348397 N/A physical interaction ComPPI
PSMD4 MCFD2 25348397 N/A physical interaction ComPPI
PSMD4 PPIA 25348397 N/A physical interaction ComPPI
PSMD4 AHCYL2 25348397 N/A physical interaction ComPPI
PSMD4 CCAR1 25348397 N/A physical interaction ComPPI
PSMD4 ELP1 25348397 N/A physical interaction ComPPI
PSMD4 NCAPD3 25348397 N/A physical interaction ComPPI
PSMD4 PSMD9 25348397 N/A physical interaction ComPPI
PSMD4 TMEM67 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMD4 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 TNFRSF21 24829148 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMD4 HERC3 25348397 N/A physical interaction ComPPI
PSMD4 SMURF1 25348397 N/A physical interaction ComPPI
PSMD4 TERF1 25348397 N/A physical interaction ComPPI
PSMD4 PPM1D 25348397 N/A physical interaction ComPPI
PSMD4 KDELR1 25348397 N/A physical interaction ComPPI
PSMD4 CYLD 25348397 N/A physical interaction ComPPI
PSMD4 BRCA1 25348397 N/A physical interaction ComPPI
PSMD4 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMD4 DCLRE1B 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD4 NAP1L1 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD4 BAP1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMD4 PRPS2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMD4 PIH1D1 24234451 24656813 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD4 ESR2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
PSMD4 TCP11L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMD4 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMD4 NEURL4 24234451 25348397 29426014 association molecular sieving ComPPI,IntAct
SEM1 PSMD4 25348397 N/A physical interaction ComPPI
PSMB4 PSMD4 25348397 N/A physical interaction ComPPI
PSMB1 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB3 PSMD4 25348397 N/A physical interaction ComPPI
CKM PSMD4 25348397 N/A physical interaction ComPPI
ADRM1 PSMD4 14525934 16990800 17139257 24234451 24811749 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,blue native page,in vivo ComPPI,HPRD,IntAct
UBLCP1 PSMD4 25348397 N/A physical interaction ComPPI
ECPAS PSMD4 25348397 N/A physical interaction ComPPI
PELO PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD4 PSMD4 16990800 19931242 24234451 physical association anti tag coimmunoprecipitation,cross-linking study IntAct

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