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GENE：SETD7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SETD7
FullNmae SET domain containing 7, histone lysine methyltransferase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30412
EnsembleID ENSG00000145391
Uniprot Q8WTS6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SETD7 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SETD7 GO:0002039,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005694,GO:0005730,GO:0006325,GO:0006974,GO:0016279,GO:0018026,GO:0018026,GO:0018027,GO:0042054,GO:0045471,GO:0045893,GO:0070828,GO:0070828,GO:0140938,GO:0140945

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SETD7 hsa:80854 path:hsa00310 Lysine degradation - Homo sapiens (human)
SETD7 hsa:80854 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SETD7 hsa:80854 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SERTAD1 SETD7 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SETD7 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 SETD7 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SETD7 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SETD7 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SETD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272039 SETD7 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016C318 SETD7 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000ED600 SETD7 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00002FC5B0 SETD7 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001B341F SETD7 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00005651EE SETD7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 SETD7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 SETD7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001799A3 SETD7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070CD2 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 SETD7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004A9320 SETD7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 SETD7 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002152A8 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000049704B SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A760 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000035AC91 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023133F SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023F008 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006372A SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039D790 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 SETD7 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TP53 SETD7 25361965 interaction type N/A PTMCode2
SETD7 TP53 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DPY30 SETD7 25348397 N/A physical interaction ComPPI
AGTR1 SETD7 25348397 N/A physical interaction ComPPI
SERTAD1 SETD7 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
H4C1 SETD7 25348397 N/A physical interaction ComPPI
SMURF2 SETD7 25348397 N/A physical interaction ComPPI
RNF111 SETD7 25348397 N/A physical interaction ComPPI
TBP SETD7 25348397 N/A physical interaction ComPPI
SMAD7 SETD7 25348397 N/A physical interaction ComPPI
MYOD1 SETD7 21859860 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RB1 SETD7 21119616 24234451 25348397 27898060 methylation reaction methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct,OmniPath
HCFC1 SETD7 12670868 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AR SETD7 25348397 N/A physical interaction ComPPI
PPP1R12A SETD7 25348397 N/A physical interaction ComPPI
MED1 SETD7 25348397 N/A physical interaction ComPPI
PRKAR1A SETD7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN2 SETD7 25348397 N/A physical interaction ComPPI
E2F1 SETD7 20603083 21320024 22836579 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMARCA4 SETD7 25348397 N/A physical interaction ComPPI
RELA SETD7 18650421 19262565 19864627 21131967 24234451 25348397 27898060 methylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,methylation reaction,physical interaction,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct,OmniPath
NR2F2 SETD7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCR1 SETD7 25348397 N/A physical interaction ComPPI
MDM2 SETD7 25348397 N/A physical interaction ComPPI
SOX2 SETD7 25348397 N/A physical interaction ComPPI
H3-4 SETD7 11779497 11850410 12372304 12389038 12514135 12540855 14525934 21273441 25042802 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
H3C15 SETD7 14525934 16415881 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KLF4 SETD7 25348397 N/A physical interaction ComPPI
TAF6 SETD7 25348397 N/A physical interaction ComPPI
SIRT1 SETD7 21245319 24234451 25348397 methylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,methylation reaction,physical interaction,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct
SETD7 TAF10 14525934 15099517 16415881 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo,methyltransferase radiometric assay ComPPI,HPRD,IntAct
SETD7 TAF7 14525934 16415881 24234451 25348397 N/A experimental interaction detection,physical interaction,in vitro,methyltransferase radiometric assay ComPPI,HPRD,IntAct
SETD7 L3MBTL1 18408754 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SETD7 DNMT1 19282482 21151116 24234451 25348397 methylation reaction,physical association anti bait coimmunoprecipitation,pull down,x-ray crystallography,methylation reaction,physical interaction,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct
SETD7 TP53 14525934 15525938 16415881 17108971 17805299 21245319 21988832 24234451 25348397 methylation reaction,physical association two hybrid,experimental interaction detection,pull down,x-ray crystallography,methylation reaction,physical interaction,competition binding,enzymatic study,methyltransferase assay,methyltransferase radiometric assay ComPPI,HPRD,IntAct
SETD7 ESR1 18471979 24101509 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SETD7 STAT3 21098664 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SETD7 A1BG 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SETD7 STEAP3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SETD7 FAM189B 25348397 N/A physical interaction ComPPI
SETD7 ZFP41 25348397 N/A physical interaction ComPPI
SETD7 CEP170 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SETD7 FOXO1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SETD7 UBXN7 25348397 N/A physical interaction ComPPI
SETD7 SMURF1 25348397 N/A physical interaction ComPPI
SETD7 ARIH1 25348397 N/A physical interaction ComPPI
SETD7 TRIM25 25348397 N/A physical interaction ComPPI
SETD7 NR1H4 22345554 24234451 25348397 27898060 methylation reaction,physical association anti bait coimmunoprecipitation,two hybrid,pull down,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct,OmniPath
H3C1 SETD7 12540855 24234451 25348397 methylation reaction nuclear magnetic resonance,x-ray crystallography,physical interaction,methyltransferase assay ComPPI,IntAct
H3-3A SETD7 25348397 N/A physical interaction ComPPI
SETD7 SETD7 21245319 24234451 methylation reaction methyltransferase assay IntAct
SETD7 DNMT1 19282482 21151116 27898060 N/A N/A OmniPath
SETD7 H3C1 11779497 12540855 15525938 16415881 18022353 22403242 27898060 stimulant N/A OmniPath
SETD7 TP53 15525938 16415881 17108971 17805299 21245319 21988832 27898060 stimulant N/A OmniPath
SETD7 TAF10 15099517 16415881 27898060 stimulant N/A OmniPath

Visualization










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