GENE：SLC1A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC1A2 |
| FullNmae | solute carrier family 1 member 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10940 |
| EnsembleID | ENSG00000110436 |
| Uniprot | P43004 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC1A2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC1A2 | GO:0005313,GO:0005313,GO:0005314,GO:0005314,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006750,GO:0006811,GO:0006836,GO:0007268,GO:0007632,GO:0008509,GO:0009410,GO:0009611,GO:0009986,GO:0015175,GO:0015501,GO:0015501,GO:0015813,GO:0016020,GO:0021537,GO:0030534,GO:0030673,GO:0031668,GO:0031982,GO:0033229,GO:0035264,GO:0042734,GO:0043200,GO:0044297,GO:0044306,GO:0045121,GO:0045121,GO:0046326,GO:0046872,GO:0070207,GO:0070633,GO:0070778,GO:0070778,GO:0070779,GO:0071314,GO:0097449,GO:0098656,GO:0098712,GO:0098712,GO:0098712,GO:0098796,GO:0098796,GO:0098810,GO:0098978,GO:0140009,GO:0150104,GO:0150104,GO:1903712 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC1A2 | hsa:6506 | path:hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| SLC1A2 | hsa:6506 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| SLC1A2 | hsa:6506 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| SLC1A2 | hsa:6506 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC1A2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | SLC1A2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | SLC1A2 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| MYCN | SLC1A2 | 16093321 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | SLC1A2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | SLC1A2 | 19558638 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | SLC1A2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SLC1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000007D64A | SLC1A2 | 22291592 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032AE90 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004929F1 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002373FD | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | SLC1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FC26E | SLC1A2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AAAFF | SLC1A2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | SLC1A2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001EB3 | SLC1A2 | 25416803 27995756 | mrna cleavage,inhibition | quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000171525 | SLC1A2 | 25416803 27995756 | mrna cleavage,inhibition | quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GRB2 | SLC1A2 | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| MAPT | SLC1A2 | 19527721 24234451 25348397 | association | anti bait coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| AJUBA | SLC1A2 | 11860269 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| RPL5 | SLC1A2 | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | PML | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | RPL17 | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | RPL23A | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | RPL32 | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | RPL38 | 25348397 | N/A | physical interaction | ComPPI |
| SLC1A2 | RPL3 | 25348397 | N/A | physical interaction | ComPPI |