GENE：SLC8A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC8A1 |
| FullNmae | solute carrier family 8 member A1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11068 |
| EnsembleID | ENSG00000183023 |
| Uniprot | P32418 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC8A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC8A1 | GO:0002026,GO:0002026,GO:0002027,GO:0005432,GO:0005432,GO:0005432,GO:0005432,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005886,GO:0005886,GO:0006811,GO:0006874,GO:0006883,GO:0006936,GO:0008092,GO:0010468,GO:0010649,GO:0010881,GO:0010881,GO:0010882,GO:0014069,GO:0014704,GO:0014704,GO:0014829,GO:0030018,GO:0030315,GO:0030315,GO:0030424,GO:0030424,GO:0030425,GO:0030501,GO:0030506,GO:0030506,GO:0035725,GO:0035725,GO:0035725,GO:0035994,GO:0042383,GO:0042383,GO:0043025,GO:0043679,GO:0044325,GO:0044557,GO:0045202,GO:0045202,GO:0051481,GO:0055013,GO:0055074,GO:0055119,GO:0055119,GO:0060048,GO:0060402,GO:0070509,GO:0070588,GO:0070588,GO:0071313,GO:0071901,GO:0071944,GO:0086012,GO:0086064,GO:0097553,GO:0098703,GO:0098719,GO:0098735,GO:0098794,GO:1903779 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC8A1 | hsa:6546 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04740 | Olfactory transduction - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| SLC8A1 | hsa:6546 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC8A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | SLC8A1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | SLC8A1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SLC8A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00005E6F45 | SLC8A1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272039 | SLC8A1 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | SLC8A1 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A4ABF | SLC8A1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AFAD1 | SLC8A1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002233F4 | SLC8A1 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000383DF4 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000535FDD | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000029EBD | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001481F9 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000512C88 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411672 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000292B1 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | SLC8A1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EC3B | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5659 | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000308E4D | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | SLC8A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | SLC8A1 | 25416803 25767890 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YWHAB | SLC8A1 | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TRPC3 | SLC8A1 | 14525934 14736881 17012351 17129578 20351294 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| YWHAQ | SLC8A1 | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CAV3 | SLC8A1 | 11821059 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| SLC8A1 | PPP3CB | 25348397 | N/A | two hybrid,in vivo | ComPPI |
| SLC8A1 | YWHAE | 14525934 16679322 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SLC8A1 | ANK2 | 16292983 25348397 27898060 | N/A | pull down,physical interaction | ComPPI,OmniPath |
| SLC8A1 | SCHIP1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |